Development Level

Tbio 23 | 11,445
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal embryo size 2 | 220
anophthalmia 2 | 33
abnormal bone structure 1 | 187
abnormal craniofacial morpholo... 1 | 33
abnormal facial morphology 1 | 17
abnormal forebrain morphology 1 | 10
abnormal head shape 1 | 10
abnormal hindbrain morphology 1 | 10
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal tail morphology 1 | 25
cleft palate 1 | 8
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased prepulse inhibition 1 | 82
dilated heart left ventricle 1 | 11
edema 1 | 59
embryonic lethality prior to t... 1 | 278
exencephaly 1 | 2
increased cardiac stroke volum... 1 | 1
increased circulating chloride... 1 | 41
microphthalmia 1 | 26
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
spina bifida 1 | 2
syndactyly 1 | 23

Disease

Carcinoma 18 | 11,493
osteosarcoma 14 | 7,950
ovarian cancer 12 | 8,520
medulloblastoma, large-cell 11 | 6,241
psoriasis 10 | 6,694
glioblastoma 7 | 5,792
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
malignant mesothelioma 6 | 3,232
adrenocortical carcinoma 5 | 1,428
interstitial cystitis 5 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
Breast cancer 4 | 3,578
Kidney cancer 4 | 2,613
Neurodegenerative disease 4 | 414
Rheumatoid arthritis 4 | 1,191
adult high grade glioma 4 | 3,801
ependymoma 4 | 4,679
oligodendroglioma 4 | 2,850
pancreatic cancer 4 | 2,398
Cataract 8 multiple types 3 | 33
Intellectual disability 3 | 1,016
Neurodegeneration with brain iron accumulation 5 3 | 9
aldosterone-producing adenoma 3 | 665
atypical teratoid / rhabdoid tumor 3 | 5,112
cystic fibrosis 3 | 1,696
group 3 medulloblastoma 3 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
invasive ductal carcinoma 3 | 2,951
lung cancer 3 | 4,740
non-small cell lung cancer 3 | 2,890
pituitary cancer 3 | 1,972
primary pancreatic ductal adenocarcinoma 3 | 1,109
primitive neuroectodermal tumor 3 | 3,035
subependymal giant cell astrocytoma 3 | 2,287
Abnormal ocular motility 2 | 19
Astrocytoma, Pilocytic 2 | 3,081
Autosomal recessive predisposition 2 | 1,442
Bipolar Disorder 2 | 666
Dementia 2 | 175
Glaucoma 2 | 239
Multiple myeloma 2 | 1,332
Muscle Rigidity 2 | 49
Nerve Degeneration 2 | 121
Neurodegeneration with brain iron accumulation 2 | 20
Parkinson's disease 2 | 392
Parkinsonian Disorders 2 | 56
Pick disease 2 | 1,894
Prostatic Neoplasms 2 | 495
Vici syndrome 2 | 14
X-linked dominant 2 | 57
active Crohn's disease 2 | 922
astrocytic glioma 2 | 2,597
diabetes mellitus 2 | 1,728
ductal carcinoma in situ 2 | 1,745
gastric carcinoma 2 | 807
lung adenocarcinoma 2 | 2,716
lung carcinoma 2 | 2,843
tuberculosis 2 | 2,010
Arthritis, Experimental 1 | 39
Autosomal dominant Robinow syndrome 2 1 | 22
Bone Diseases, Developmental 1 | 27
CHARGE syndrome 1 | 26
Cervical Dystonia 1 | 26
Conjunctivitis 1 | 53
Conjunctivitis, recurrent 1 | 37
Cowpox 1 | 16
Dermatofibrosarcoma protuberans 1 | 15
Edema 1 | 81
Frontal release signs 1 | 3
Hepatitis, Chronic 1 | 23
Increased susceptibility to bacterial infections 1 | 42
Lipidoses 1 | 19
Lipoidosis 1 | 19
Malignant tumor of prostate 1 | 26
Mask-like facies 1 | 25
Mastoiditis 1 | 8
Menkes disease 1 | 19
Microphthalmia 1 | 76
Movement disease 1 | 11
Neurodegeneration with brain iron accumulation (NBIA) 1 | 2
Panhypogammaglobulinemia 1 | 9
Paraparesis 1 | 6
Paraparesis, Spastic 1 | 16
Poor speech 1 | 37
Postural instability 1 | 19
Problems speaking 1 | 37
Proctitis 1 | 13
Prone to bacterial infection 1 | 42
Pyuria 1 | 5
Rapidly progressive 1 | 27
Rapidly progressive disorder 1 | 27
Recurrent bacterial infection 1 | 42
Rigid spine muscular dystrophy 1 1 | 14
Slowed saccades 1 | 12
Small intestine cancer 1 | 12
Spasmodic torticollis 1 | 17
Supranuclear gaze palsy 1 | 6
Torticollis 1 | 18
Wilson disease 1 | 16
alcohol-related neurodevelopmental disorder 1 | 13

Tissue

Endocrine System 25 | 18,159
Blood and immune system 24 | 16,909
Male tissues 24 | 17,142
Nervous System 24 | 16,725
Digestive Tract 23 | 17,369
Female tissues 23 | 17,400
Liver and Pancreas 23 | 16,750
Respiratory system 23 | 16,393
Skin and soft tissues 23 | 17,230
Urinary Tract 23 | 16,678
Cardiovascular System 21 | 15,192

Target Family

Non-IDG 23 | 12,091
Epigenetic 1 | 242
Transporter 1 | 473

GO Function

phosphatidylinositol-3,5-bisph... 25 | 25
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sorting nexin-14 SNX14 Tbio Non-IDG -0.86091 6.82 56
Pleckstrin homology-like domain family A member 3 PHLDA3 Tbio Non-IDG -0.83900 8.89 101
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
Junctophilin-2 JPH2 Tbio Non-IDG -2.21890 163.0 229
WASH complex subunit 2C WASHC2C Tbio Non-IDG -0.83634 0.00000 45
Pleckstrin-2 PLEK2 Tbio Non-IDG -1.09971 14.3 40
SEC14 domain and spectrin repeat-containing protein 1 SESTD1 Tbio Non-IDG -0.75718 5.72 91
Clavesin-1 CLVS1 Tbio Non-IDG -0.31702 2.43 61
Retinoschisin RS1 Tbio Non-IDG -2.10828 131.3 39
SH3 and PX domain-containing protein 2B SH3PXD2B Tbio Non-IDG -1.72872 53.3 71