Development Level

Tbio 11 | 11,445
Tdark 1 | 6,588

IMPC Phenotype

decreased monocyte cell number 1 | 8
decreased neutrophil cell numb... 1 | 42
decreased total body fat amoun... 1 | 207
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased startle reflex 1 | 112
persistence of hyaloid vascula... 1 | 33
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
tremors 1 | 39

Disease

Carcinoma 12 | 11,493
ovarian cancer 8 | 8,520
ependymoma 7 | 4,679
medulloblastoma, large-cell 7 | 6,241
Centronuclear myopathy 6 | 27
lung cancer 6 | 4,740
osteosarcoma 6 | 7,950
oligodendroglioma 5 | 2,850
psoriasis 5 | 6,694
adult high grade glioma 4 | 3,801
astrocytic glioma 4 | 2,597
Acquired scoliosis 3 | 281
Charcot-Marie-Tooth disease 3 | 62
Curvature of spine 3 | 282
Kidney cancer 3 | 2,613
Pick disease 3 | 1,894
atypical teratoid / rhabdoid tumor 3 | 5,112
glioblastoma 3 | 5,792
group 3 medulloblastoma 3 | 4,104
group 4 medulloblastoma 3 | 1,855
Astrocytoma, Pilocytic 2 | 3,081
Autosomal recessive predisposition 2 | 1,442
Bell Palsy 2 | 58
Breast cancer 2 | 3,578
Dental caries 2 | 164
Epilepsy 2 | 792
Facial Paresis 2 | 59
Facial muscle weakness of muscles innervated by CN VII 2 | 58
Myopathies, Structural, Congenital 2 | 15
Neurodegenerative disease 2 | 414
Neuropathy 2 | 261
Oculocerebrorenal syndrome 2 | 29
Seizures 2 | 596
aldosterone-producing adenoma 2 | 665
colon cancer 2 | 1,478
dermatomyositis 2 | 966
lung carcinoma 2 | 2,843
non primary Sjogren syndrome sicca 2 | 891
primitive neuroectodermal tumor 2 | 3,035
spina bifida 2 | 1,074
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 2,010
Akinesia 1 | 13
Arachnodactyly 1 | 49
Atrioventricular block 1 | 35
Big calvaria 1 | 147
Blepharoptosis 1 | 231
Breast Neoplasms 1 | 445
Congenital clubfoot 1 | 109
Congenital pes cavus 1 | 88
Creutzfeldt-Jakob disease 1 | 21
Decreased liver function 1 | 24
Degenerative brain disorder 1 | 100
Distal amyotrophy 1 | 51
Distal sensory impairment 1 | 52
Dysarthria 1 | 192
Electromyogram abnormal 1 | 49
Fatigue 1 | 182
Flexion contractures of joints 1 | 93
Gastrointestinal system disease 1 | 54
Gaucher disease type 1 1 | 180
Generalized muscle weakness 1 | 57
Hemangioma, Cavernous 1 | 20
Hypokinesia 1 | 19
Hypophonia 1 | 7
Hypotonia, severe 1 | 33
Increased head circumference 1 | 147
Increased size of cranium 1 | 147
Increased size of skull 1 | 147
Liver dysfunction, mild 1 | 24
Lupus nephritis 1 | 13
Mammary Neoplasms 1 | 425
Mask-like facies 1 | 25
Motor delay 1 | 147
Muscle Rigidity 1 | 49
Myotonic dystrophy type 1 1 | 17
Narrow face 1 | 54
Neck muscle weakness 1 | 17
Neurogenic Muscular Atrophy 1 | 139
Neurogenic muscle atrophy, especially in the lower limbs 1 | 139
No development of motor milestones 1 | 147
Parkinsonian Disorders 1 | 56
Polyhydramnios 1 | 108
Postural instability 1 | 19
Proximal muscle weakness 1 | 47
Proximal neurogenic muscle weakness 1 | 47
Ptosis 1 | 48
Pyloric Stenosis 1 | 47
Reduced fetal movement 1 | 51
Respiratory Distress Syndrome 1 | 15
Respiratory Failure 1 | 104
Resting Tremor 1 | 9
Shuffling, short-stepped gait 1 | 5
Skeletal muscle atrophy 1 | 139
Thin face 1 | 54
Tremor 1 | 113
Variant Creutzfeldt-Jakob disease 1 | 16
Voice Fatigue 1 | 7
X- linked recessive 1 | 110
muscle degeneration 1 | 139

Tissue

Blood and immune system 12 | 16,909
Cardiovascular System 12 | 15,192
Digestive Tract 12 | 17,369
Endocrine System 12 | 18,159
Female tissues 12 | 17,400
Liver and Pancreas 12 | 16,750
Male tissues 12 | 17,142
Nervous System 12 | 16,725
Respiratory system 12 | 16,393
Skin and soft tissues 12 | 17,230
Urinary Tract 12 | 16,678

Target Family

Enzyme 9 | 4,145
Non-IDG 3 | 12,091

GO Function

phosphatidylinositol-3,5-bisph... 12 | 12
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myotubularin-related protein 3 MTMR3 Tbio Enzyme -1.05980 10.7 33
Myotubularin-related protein 1 MTMR1 Tbio Enzyme -0.89579 6.93 82
Synaptojanin-2 SYNJ2 Tbio Non-IDG -1.15573 16.3 157
Synaptojanin-1 SYNJ1 Tbio Non-IDG -1.76329 62.0 93
Myotubularin-related protein 4 MTMR4 Tbio Enzyme -0.76288 7.50 138
Myotubularin MTM1 Tbio Enzyme -2.72507 527.3 235
Myotubularin-related protein 9 MTMR9 Tbio Non-IDG -0.73836 6.81 80
Myotubularin-related protein 2 MTMR2 Tbio Enzyme -1.64906 46.5 124
Myotubularin-related protein 14 MTMR14 Tbio Enzyme -0.98565 10.2 154
Myotubularin-related protein 7 MTMR7 Tdark Enzyme -0.42461 3.79 39