Development Level

Tbio 49 | 11,651
Tdark 17 | 6,593
Tchem 9 | 1,388
Tclin 2 | 612

Collection

Kinase: IDG Consortium (Target... 4 | 125

IMPC Phenotype

preweaning lethality, complete... 5 | 979
preweaning lethality, incomple... 4 | 499
abnormal embryo size 3 | 220
decreased circulating potassiu... 2 | 20
decreased fasted circulating g... 2 | 65
decreased prepulse inhibition 2 | 82
embryonic growth retardation 2 | 106
embryonic lethality prior to t... 2 | 278
hyperactivity 2 | 148
impaired glucose tolerance 2 | 75
increased circulating alkaline... 2 | 122
increased hematocrit 2 | 46
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal lens morphology 1 | 81
abnormal maxilla morphology 1 | 17
abnormal retinal vasculature m... 1 | 27
abnormal vertebrae morphology 1 | 18
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating triglyce... 1 | 79
decreased lean body mass 1 | 135
decreased threshold for audito... 1 | 26
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
head bobbing 1 | 5
hypoactivity 1 | 132
increased circulating chloride... 1 | 41
increased circulating phosphat... 1 | 26
increased erythrocyte cell num... 1 | 39
increased mean corpuscular hem... 1 | 96
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
microphthalmia 1 | 26
prolonged PQ interval 1 | 5
prolonged PR interval 1 | 15
small epididymis 1 | 3

Disease

Carcinoma 55 | 11,493
ovarian cancer 45 | 8,520
medulloblastoma, large-cell 35 | 6,241
osteosarcoma 35 | 7,950
glioblastoma 33 | 5,792
psoriasis 31 | 6,694
atypical teratoid / rhabdoid tumor 28 | 5,112
ependymoma 24 | 4,679
Kidney cancer 21 | 2,613
Breast cancer 20 | 3,578
adult high grade glioma 18 | 3,801
lung cancer 17 | 4,740
Astrocytoma, Pilocytic 16 | 3,081
tuberculosis 16 | 2,010
group 3 medulloblastoma 15 | 4,104
pituitary cancer 15 | 1,972
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
lung carcinoma 14 | 2,843
astrocytic glioma 13 | 2,597
diabetes mellitus 13 | 1,728
invasive ductal carcinoma 13 | 2,951
Pick disease 12 | 1,894
malignant mesothelioma 12 | 3,232
oligodendroglioma 12 | 2,850
pancreatic cancer 12 | 2,398
subependymal giant cell astrocytoma 11 | 2,287
ulcerative colitis 11 | 1,819
juvenile dermatomyositis 10 | 1,187
group 4 medulloblastoma 9 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
primitive neuroectodermal tumor 9 | 3,035
progressive supranuclear palsy 9 | 676
interstitial cystitis 8 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
non-small cell lung cancer 8 | 2,890
primary pancreatic ductal adenocarcinoma 8 | 1,109
Cancer 7 | 2,499
acute quadriplegic myopathy 7 | 1,158
pediatric high grade glioma 7 | 1,064
Autosomal recessive predisposition 6 | 1,442
cystic fibrosis 6 | 1,696
lung adenocarcinoma 6 | 2,716
Obesity 5 | 678
Rheumatoid arthritis 5 | 1,191
Schizophrenia 5 | 1,160
adrenocortical carcinoma 5 | 1,428
breast carcinoma 5 | 1,638
ductal carcinoma in situ 5 | 1,745
spina bifida 5 | 1,074
Arthritis 4 | 290
Atherosclerosis 4 | 291
Chronic Lymphocytic Leukemia 4 | 262
Liver Cirrhosis, Experimental 4 | 769
Liver cancer 4 | 604
Neurodegenerative disease 4 | 414
acute myeloid leukemia 4 | 783
aldosterone-producing adenoma 4 | 665
colon cancer 4 | 1,478
gastric carcinoma 4 | 807
sonic hedgehog group medulloblastoma 4 | 467
tuberculosis and treatment for 3 months 4 | 179
Alzheimer's disease 3 | 658
Cardiomegaly 3 | 116
Edema 3 | 81
Intellectual disability 3 | 1,016
Multiple myeloma 3 | 1,332
Neuropathy 3 | 261
Prostatic Neoplasms 3 | 495
Waldenstrons macroglobulinemia 3 | 765
astrocytoma 3 | 1,146
cutaneous lupus erythematosus 3 | 1,057
medulloblastoma 3 | 720
non primary Sjogren syndrome sicca 3 | 891
primary Sjogren syndrome 3 | 735
Amyotrophic lateral sclerosis 2 | 451
Arthritis, Rheumatoid 2 | 174
Autistic Disorder 2 | 364
Bipolar Disorder 2 | 666
Cardiovascular system disease 2 | 246
Diarrhea 2 | 253
Down syndrome 2 | 499
Epilepsy 2 | 792
Essential Hypertension 2 | 94
Hypertension 2 | 396
Hypotonia, severe 2 | 33
Kidney disease 2 | 430
Melanoma 2 | 711
Myopathy 2 | 185
Retinal Degeneration 2 | 106
Seizures 2 | 596
active Crohn's disease 2 | 922
atypical teratoid/rhabdoid tumor 2 | 357
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
cystic fibrosis and chronic rhinosinusitis 2 | 214
dermatomyositis 2 | 966
esophageal adenocarcinoma 2 | 737
mucosa-associated lymphoid tissue lymphoma 2 | 484
pancreatic carcinoma 2 | 562
tuberculosis and treatment for 6 months 2 | 409

Tissue

Blood and immune system 75 | 16,909
Endocrine System 75 | 18,159
Liver and Pancreas 74 | 16,750
Male tissues 74 | 17,142
Urinary Tract 74 | 16,678
Digestive Tract 73 | 17,369
Female tissues 73 | 17,400
Nervous System 73 | 16,725
Skin and soft tissues 73 | 17,230
Respiratory system 72 | 16,393
Cardiovascular System 70 | 15,192

Target Family

Non-IDG 52 | 12,091
Kinase 8 | 634
Enzyme 6 | 4,145
Ion Channel 4 | 344
Transcription Factor 4 | 1,400
Epigenetic 3 | 242

GO Function

phosphatidylinositol binding 77 | 77
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sorting nexin-22 SNX22 Tdark Non-IDG -0.21085 1.62 25
Tubby-related protein 4 TULP4 Tdark Transcription Factor -1.15928 14.0 44
Zinc finger CCHC domain-containing protein 2 ZCCHC2 Tdark Non-IDG 0.38 0.40 16
Sorting nexin-9 SNX9 Tbio Non-IDG -2.00279 102.8 241
Sorting nexin-8 SNX8 Tbio Non-IDG -1.38931 25.5 152
Sorting nexin-32 SNX32 Tdark Non-IDG 0.35 0.28 89
Talin-1 TLN1 Tbio Non-IDG -1.94109 90.0 426
Sorting nexin-7 SNX7 Tdark Non-IDG -0.58912 4.55 120
V(D)J recombination-activating protein 2 RAG2 Tbio Epigenetic -2.94111 784.2 194
Sorting nexin-1 SNX1 Tbio Non-IDG -1.59343 43.7 285