Development Level

Tchem 3 | 1,598
Tclin 2 | 613

IMPC Phenotype

abnormal embryo size 1 | 220
decreased circulating alanine ... 1 | 47
decreased circulating creatini... 1 | 39
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 5 | 11,493
Cancer 4 | 2,499
Diffuse large B-cell lymphoma 4 | 39
Lymphoma, Large B-Cell, Diffuse 4 | 34
Schizophrenia 4 | 1,160
follicular lymphoma 4 | 20
medulloblastoma, large-cell 4 | 6,241
osteosarcoma 4 | 7,950
ovarian cancer 4 | 8,520
Kidney cancer 3 | 2,613
atypical teratoid / rhabdoid tumor 3 | 5,112
glioblastoma 3 | 5,792
juvenile dermatomyositis 3 | 1,187
lung cancer 3 | 4,740
psoriasis 3 | 6,694
Astrocytoma, Pilocytic 2 | 3,081
Breast cancer 2 | 3,578
DOID:2627 2 | 94
Hypothyroidism 2 | 122
Prostatic Neoplasms 2 | 495
Splenomegaly 2 | 190
Upper respiratory tract disease 2 | 15
Waldenstrons macroglobulinemia 2 | 765
adult high grade glioma 2 | 3,801
ependymoma 2 | 4,679
group 4 medulloblastoma 2 | 1,855
interstitial cystitis 2 | 2,312
invasive ductal carcinoma 2 | 2,951
pancreatic cancer 2 | 2,398
primary Sjogren syndrome 2 | 735
primitive neuroectodermal tumor 2 | 3,035
progressive supranuclear palsy 2 | 676
subependymal giant cell astrocytoma 2 | 2,287
ulcerative colitis 2 | 1,819
Abnormality of the penis 1 | 7
Action Tremor 1 | 22
Adenocarcinoma Of Esophagus 1 | 14
Adenocarcinoma of lung (disorder) 1 | 60
Angioid streaks 1 | 11
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1 1 | 13
Bronchioloalveolar Adenocarcinoma 1 | 14
Cardiovascular Abnormalities 1 | 31
Chronic lymphoid leukemia, disease 1 | 13
Compartment syndrome 1 | 11
Congenital abnormality of vein 1 | 3
Congenital arteriovenous malformation 1 | 8
Conjunctival hamartoma 1 | 7
Cowden disease 1 | 18
Cutis marmorata 1 | 32
Facial asymmetry 1 | 32
Fetal alcohol syndrome 1 | 22
Fibrous skin tumor of tuberous sclerosis 1 | 18
Fissured tongue 1 | 25
Gastric Cancer, Hereditary Diffuse 1 | 12
Gastrointestinal Hemorrhage 1 | 52
Gastrointestinal hamartomatous polyps 1 | 10
Goiter 1 | 38
Hamartoma Syndrome, Multiple 1 | 10
Hamartomatous polyp 1 | 10
Hematologic Neoplasms 1 | 22
Hemimegalencephaly 1 | 5
Hereditary Nonpolyposis Colorectal Cancer 1 | 11
Hereditary nonpolyposis colorectal carcinoma 1 | 18
Hyperkeratosis, generalized 1 | 14
Hyperthyroidism 1 | 53
Increased gastric cancer 1 | 21
Irritation - emotion 1 | 68
Legionnaires' disease 1 | 20
Leiomyosarcoma of uterus 1 | 13
Lymphoma, Mantle-Cell 1 | 11
Macrocephaly 1 | 11
Macule 1 | 19
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse 1 | 12
Malignant neoplasm of breast 1 | 15
Malignant neoplasm of ovary 1 | 4
Malignant tumor of colon 1 | 19
Micronodular cirrhosis 1 | 12
Mucosal telangiectasiae 1 | 14
Multiple, subcutaneous nodules 1 | 53
Neoplasm of stomach 1 | 11
Neuroleptic malignant syndrome 1 | 9
Nevus, Epidermal 1 | 5
Numerous nevi 1 | 5
Ornithosis 1 | 9
Papule 1 | 43
Penile Neoplasms 1 | 4
Pericardial effusion 1 | 14
Polyp of large intestine 1 | 8
Port-Wine Stain 1 | 8
Rectal Neoplasms 1 | 18
Recurrent sinopulmonary infections 1 | 6
Skin Diseases, Bacterial 1 | 7
Stomach Carcinoma 1 | 11
Subacute progressive viral hepatitis 1 | 9
Subcutaneous lipomas 1 | 9
Subcutaneous nodule 1 | 53
Terminal tremor 1 | 20
Thyroid Gland Follicular Adenoma 1 | 9
Thyroiditis 1 | 29
Transitional cell carcinoma of bladder 1 | 17

Tissue

Blood and immune system 5 | 16,909
Cardiovascular System 5 | 15,192
Digestive Tract 5 | 17,369
Endocrine System 5 | 18,159
Female tissues 5 | 17,400
Liver and Pancreas 5 | 16,750
Male tissues 5 | 17,142
Nervous System 5 | 16,725
Respiratory system 5 | 16,393
Skin and soft tissues 5 | 17,230
Urinary Tract 5 | 16,678

Target Family

Kinase 5 | 634

GO Function

phosphatidylinositol 3-kinase ... 5 | 5
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

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