Development Level

Tbio 18 | 11,445
Tchem 3 | 1,598

Collection

GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal pupil morphology 1 | 2
abnormal skin morphology 1 | 50
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating potassiu... 1 | 20
decreased lactate dehydrogenas... 1 | 16
decreased leukocyte cell numbe... 1 | 73
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
enlarged spleen 1 | 41
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
limb grasping 1 | 41
scaly skin 1 | 4
thick skin 1 | 4

Disease

Carcinoma 12 | 11,493
ovarian cancer 12 | 8,520
psoriasis 11 | 6,694
glioblastoma 10 | 5,792
atypical teratoid / rhabdoid tumor 8 | 5,112
diabetes mellitus 8 | 1,728
ependymoma 8 | 4,679
osteosarcoma 8 | 7,950
Atherosclerosis 7 | 291
Coronary artery disease 7 | 268
Obesity 7 | 678
lung cancer 7 | 4,740
malignant mesothelioma 7 | 3,232
medulloblastoma, large-cell 7 | 6,241
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Lipid metabolism disorder 6 | 114
oligodendroglioma 6 | 2,850
astrocytic glioma 5 | 2,597
Cardiovascular system disease 4 | 246
adult high grade glioma 4 | 3,801
interstitial cystitis 4 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
invasive ductal carcinoma 4 | 2,951
lung adenocarcinoma 4 | 2,716
pediatric high grade glioma 4 | 1,064
subependymal giant cell astrocytoma 4 | 2,287
Astrocytoma, Pilocytic 3 | 3,081
Cancer 3 | 2,499
Cone dystrophy 3 | 71
Hypercholesterolemia, Familial 3 | 23
Hyperlipoproteinemia Type II 3 | 12
Hypertensive disease 3 | 292
Hypertriglyceridemia 3 | 17
Pediatric Obesity 3 | 4
Type 2 diabetes mellitus 3 | 272
Vascular disease 3 | 319
astrocytoma 3 | 1,146
ductal carcinoma in situ 3 | 1,745
group 4 medulloblastoma 3 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
juvenile dermatomyositis 3 | 1,187
lung carcinoma 3 | 2,843
Acquired scoliosis 2 | 281
Alzheimer's disease 2 | 658
Amyloidosis 2 | 67
Atopic dermatitis 2 | 952
Autosomal recessive predisposition 2 | 1,442
Breast cancer 2 | 3,578
Cardiovascular Diseases 2 | 59
Cerebrovascular disease 2 | 238
Chemical and Drug Induced Liver Injury 2 | 195
Cholestasis 2 | 155
Curvature of spine 2 | 282
Difficulties with night vision 2 | 87
Down syndrome 2 | 499
Dull intelligence 2 | 645
Dyslipidemias 2 | 27
Hemiplegia and hemiparesis 2 | 38
Hypertension 2 | 396
Increase in blood pressure 2 | 119
Intellectual disability 2 | 1,016
Kidney cancer 2 | 2,613
Kidney disease 2 | 430
Leukemia, Myelocytic, Acute 2 | 120
Leukemia, Myeloid, Acute 2 | 105
Liver Cirrhosis, Experimental 2 | 769
Low intelligence 2 | 645
Macular degeneration 2 | 65
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Multiple myeloma 2 | 1,332
Night Blindness 2 | 101
Nystagmus 2 | 317
Photodysphoria 2 | 121
Photophobia 2 | 121
Poor school performance 2 | 645
Retinal Degeneration 2 | 106
Retinitis Pigmentosa 2 | 226
Schizophrenia 2 | 1,160
acute quadriplegic myopathy 2 | 1,158
adrenocortical carcinoma 2 | 1,428
aldosterone-producing adenoma 2 | 665
cystic fibrosis 2 | 1,696
group 3 medulloblastoma 2 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
non primary Sjogren syndrome sicca 2 | 891
non-small cell lung cancer 2 | 2,890
spina bifida 2 | 1,074
Behcet Syndrome 1 | 21
Decreased amplitudes on flash visual electroretinogram 1 | 13
Eye poking 1 | 2
Femoral bowing 1 | 20
Fundus atrophy 1 | 2
Juvenile xanthogranuloma 1 | 7
Learning Disorders 1 | 29
Partial central choroid dystrophy 1 | 11
Piebaldism 1 | 15
Severe early childhood onset retinal dystrophy 1 | 4
Tibial bowing 1 | 19
Tuberous sclerosis 1 | 19

Tissue

Digestive Tract 21 | 17,369
Endocrine System 21 | 18,159
Female tissues 20 | 17,400
Liver and Pancreas 20 | 16,750
Skin and soft tissues 20 | 17,230
Blood and immune system 19 | 16,909
Male tissues 18 | 17,142
Nervous System 18 | 16,725
Respiratory system 17 | 16,393
Urinary Tract 17 | 16,678
Cardiovascular System 15 | 15,192

Target Family

Non-IDG 16 | 12,091
Enzyme 3 | 4,145
GPCR 2 | 408

GO Function

phosphatidylcholine binding 21 | 21
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Charged multivesicular body protein 3 CHMP3 Tbio Non-IDG -1.39658 35.6 64
Choline-phosphate cytidylyltransferase A PCYT1A Tbio Enzyme -2.39713 242.7 191
Phosphatidylinositol transfer protein alpha isoform PITPNA Tbio Non-IDG -1.53999 36.3 126
Apolipoprotein A-V APOA5 Tbio Non-IDG -2.58826 425.0 481
Apolipoprotein C-I APOC1 Tbio Non-IDG -2.39715 256.4 274
Neurofibromin NF1 Tbio Non-IDG -3.60161 4054.2 355
Membrane-associated phosphatidylinositol transfer protein 1 PITPNM1 Tbio Non-IDG -1.99576 100.1 173
RAS guanyl-releasing protein 1 RASGRP1 Tchem Non-IDG -1.99263 105.6 99
Cholesteryl ester transfer protein CETP Tchem Non-IDG -3.20658 1755.9 264
Phosphatidylinositol transfer protein beta isoform PITPNB Tbio Non-IDG -1.39303 25.2 194