Development Level

Tbio 16 | 11,445
Tchem 2 | 1,598

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

abnormal embryo size 1 | 220
anophthalmia 1 | 33
decreased circulating calcium ... 1 | 36
decreased circulating potassiu... 1 | 20
decreased heart left ventricle... 1 | 28
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
dilated heart left ventricle 1 | 11
embryonic lethality prior to t... 1 | 278
improved glucose tolerance 1 | 79
increased cardiac stroke volum... 1 | 1
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 96
prenatal lethality prior to he... 1 | 87
preweaning lethality, complete... 1 | 979
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

Carcinoma 13 | 11,493
glioblastoma 10 | 5,792
ovarian cancer 10 | 8,520
ependymoma 9 | 4,679
osteosarcoma 9 | 7,950
psoriasis 8 | 6,694
group 3 medulloblastoma 7 | 4,104
malignant mesothelioma 7 | 3,232
adult high grade glioma 6 | 3,801
atypical teratoid / rhabdoid tumor 6 | 5,112
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
medulloblastoma, large-cell 6 | 6,241
non-small cell lung cancer 6 | 2,890
Breast cancer 5 | 3,578
Kidney cancer 5 | 2,613
interstitial cystitis 5 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
lung cancer 5 | 4,740
Pick disease 4 | 1,894
Schizophrenia 4 | 1,160
astrocytic glioma 4 | 2,597
tuberculosis 4 | 2,010
Alzheimer's disease 3 | 658
Astrocytoma, Pilocytic 3 | 3,081
Autosomal recessive predisposition 3 | 1,442
Bipolar Disorder 3 | 666
cystic fibrosis 3 | 1,696
juvenile dermatomyositis 3 | 1,187
lung carcinoma 3 | 2,843
oligodendroglioma 3 | 2,850
pancreatic cancer 3 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pediatric high grade glioma 3 | 1,064
sonic hedgehog group medulloblastoma 3 | 467
subependymal giant cell astrocytoma 3 | 2,287
Babinski Reflex 2 | 100
Cardiomyopathy 2 | 116
Degenerative polyarthritis 2 | 115
Dementia 2 | 175
Hyperreflexia 2 | 209
Muscle Spasticity 2 | 195
Neurodegenerative disease 2 | 414
Osteoarthritis 2 | 184
Retinal Degeneration 2 | 106
Rheumatoid arthritis 2 | 1,191
active Crohn's disease 2 | 922
active ulcerative colitis 2 | 764
acute quadriplegic myopathy 2 | 1,158
diabetes mellitus 2 | 1,728
ductal carcinoma in situ 2 | 1,745
gastric carcinoma 2 | 807
hereditary spastic paraplegia 2 | 318
invasive ductal carcinoma 2 | 2,951
pituitary cancer 2 | 1,972
primary pancreatic ductal adenocarcinoma 2 | 1,109
primitive neuroectodermal tumor 2 | 3,035
Abnormal auditory evoked potential 1 | 7
Abnormal color vision 1 | 31
Abnormality of the fingernails 1 | 51
Adverse reaction to drug 1 | 61
Blue/yellow color vision defect 1 | 3
Cocaine abuse 1 | 19
Color Blindness, Blue 1 | 3
Color Blindness, Red-Green 1 | 4
Color vision defect 1 | 33
Color vision defect, severe 1 | 31
Cone dystrophy 1 | 71
Dermatitis herpetiformis 1 | 12
Drug-Related Side Effects and Adverse Reactions 1 | 62
Hallucinations 1 | 34
Hallucinations, Sensory 1 | 33
Hypertriglyceridemia 1 | 17
Hypertrophic Cardiomyopathy 1 | 117
Insulin Resistance 1 | 72
Leukonychia 1 | 6
Mask-like facies 1 | 25
Menkes disease 1 | 19
Muscle Rigidity 1 | 49
Myoclonus 1 | 74
Nail disease 1 | 9
Nerve Degeneration 1 | 121
Neuronal Ceroid-Lipofuscinoses 1 | 4
Neuronal ceroid lipofuscinosis 1 | 28
Oculocerebrorenal syndrome 1 | 29
Parkinsonian Disorders 1 | 56
Peripheral Neuropathy 1 | 134
Photodysphoria 1 | 121
Photophobia 1 | 121
Postural instability 1 | 19
Progressive spasticity 1 | 6
Rapidly progressive 1 | 27
Rapidly progressive disorder 1 | 27
Red/green color vision defect 1 | 3
Reduced visual acuity 1 | 63
Sebaceous adenoma 1 | 26
Slowed saccades 1 | 12
Supranuclear gaze palsy 1 | 6
Weight Gain 1 | 100
Wilson disease 1 | 16

Tissue

Blood and immune system 18 | 16,909
Cardiovascular System 18 | 15,192
Digestive Tract 18 | 17,369
Endocrine System 18 | 18,159
Female tissues 18 | 17,400
Liver and Pancreas 18 | 16,750
Male tissues 18 | 17,142
Nervous System 18 | 16,725
Respiratory system 18 | 16,393
Skin and soft tissues 18 | 17,230
Urinary Tract 18 | 16,678

Target Family

Non-IDG 13 | 12,091
Enzyme 3 | 4,145
Kinase 1 | 634
Transporter 1 | 473

GO Function

phosphatidic acid binding 18 | 18
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cytoplasmic phosphatidylinositol transfer protein 1 PITPNC1 Tbio Non-IDG -0.74280 6.46 51
Rap guanine nucleotide exchange factor 2 RAPGEF2 Tbio Non-IDG -1.41107 29.0 79
Junctophilin-2 JPH2 Tbio Non-IDG -2.21890 163.0 229
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 PLCD1 Tchem Enzyme -2.17969 140.9 120
SEC14 domain and spectrin repeat-containing protein 1 SESTD1 Tbio Non-IDG -0.75718 5.72 91
Membrane-associated phosphatidylinositol transfer protein 1 PITPNM1 Tbio Non-IDG -1.99576 100.1 173
MICAL-like protein 1 MICALL1 Tbio Non-IDG -0.79264 7.57 82
Serine/threonine-protein kinase MARK1 MARK1 Tchem Kinase -1.77236 56.1 318
Dynamin-like 120 kDa protein, mitochondrial OPA1 Tbio Non-IDG -2.51554 307.1 210
Gasdermin-D GSDMD Tbio Non-IDG -1.55687 34.2 87