Development Level

Tbio 8 | 11,445
Tchem 2 | 1,598

IMPC Phenotype

preweaning lethality, incomple... 2 | 499
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal heart morphology 1 | 162
abnormal neural tube closure 1 | 46
abnormal placenta size 1 | 20
corneal opacity 1 | 32
decreased circulating glucose ... 1 | 126
decreased hemoglobin content 1 | 68
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 50
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged uterus 1 | 11
hemorrhage 1 | 23
hydrometra 1 | 53
impaired pupillary reflex 1 | 26
increased blood uric acid leve... 1 | 5
increased monocyte cell number 1 | 63
pale yolk sac 1 | 25
pallor 1 | 34
preweaning lethality, complete... 1 | 979
small superior vagus ganglion 1 | 74
vertebral fusion 1 | 23

Disease

osteosarcoma 8 | 7,950
Carcinoma 7 | 11,493
atypical teratoid / rhabdoid tumor 7 | 5,112
glioblastoma 7 | 5,792
medulloblastoma, large-cell 6 | 6,241
Cancer 5 | 2,499
malignant mesothelioma 5 | 3,232
ovarian cancer 5 | 8,520
astrocytic glioma 4 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
lung cancer 4 | 4,740
pancreatic cancer 4 | 2,398
psoriasis 4 | 6,694
Kidney cancer 3 | 2,613
Pick disease 3 | 1,894
acute quadriplegic myopathy 3 | 1,158
colon cancer 3 | 1,478
ependymoma 3 | 4,679
group 3 medulloblastoma 3 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
invasive ductal carcinoma 3 | 2,951
non-small cell lung cancer 3 | 2,890
pediatric high grade glioma 3 | 1,064
pituitary cancer 3 | 1,972
primitive neuroectodermal tumor 3 | 3,035
Acquired metabolic disease 2 | 336
Amyotrophic lateral sclerosis 2 | 451
Carcinoma, Hepatocellular 2 | 228
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Type 2 2 | 142
Fatty liver disease 2 | 103
Hyperglycemia 2 | 137
Intellectual disability 2 | 1,016
Liver carcinoma 2 | 240
Muscle Spasticity 2 | 195
Obesity 2 | 678
Schizophrenia 2 | 1,160
diabetes mellitus 2 | 1,728
gastric cancer 2 | 459
group 4 medulloblastoma 2 | 1,855
hepatocellular carcinoma 2 | 547
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
oligodendroglioma 2 | 2,850
pancreatic carcinoma 2 | 562
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
posterior fossa group B ependymoma 2 | 416
tuberculosis and treatment for 6 months 2 | 409
ATYPICAL MYCOBACTERIOSIS, FAMILIAL, X-LINKED 1 (disorder) 1 | 1
Abnormal hand morphology 1 | 2
Abnormal pigmentation 1 | 25
Accessory nipple 1 | 11
Accessory rib 1 | 10
Acquired deformity of finger 1 | 3
Asymmetric growth 1 | 5
Atrophic, patchy alopecia 1 | 1
Bloch Sulzberger syndrome 1 | 1
Cleft palate with cleft lip 1 | 23
Congenital absence of breast 1 | 1
Congenital hemivertebra 1 | 25
Congenital hypoplasia of breast 1 | 25
Dental abnormalities 1 | 60
Ectodermal Dysplasia 1 | 14
Ectodermal Dysplasia, Anhidrotic, with Immunodeficiency, Osteopetrosis, and Lymphedema 1 | 1
Ectodermal dysplasia, hypohidrotic, with immune deficiency 1 | 2
Erythema 1 | 58
Exanthema 1 | 43
Fine hair 1 | 42
Flushing 1 | 60
Hearing abnormality 1 | 12
Hyperkeratosis 1 | 50
Hypoplasia of nipple 1 | 16
Hypoplastic fingernails 1 | 11
INVASIVE PNEUMOCOCCAL DISEASE, RECURRENT ISOLATED, 2 (disorder) 1 | 1
IgG Deficiency 1 | 22
Immunodeficiency without anhidrotic ectodermal dysplasia 1 | 1
Immunoglobulin A deficiency (disorder) 1 | 19
Impaired memory B-cell generation 1 | 3
Increased IgM levels 1 | 16
Increased susceptibility to bacterial infections 1 | 42
Irregular hyperpigmentation 1 | 33
Kyphoscoliosis deformity of spine 1 | 60
Lymphatic obstruction 1 | 21
Onset of lymphedema around puberty 1 | 21
Onychogryposis 1 | 13
Oral cleft 1 | 18
Peg-shaped incisors 1 | 6
Pitting of nails 1 | 6
Pointed incisor 1 | 6
Prone to bacterial infection 1 | 42
Recurrent bacterial infection 1 | 42
Recurrent mycobacterium avium complex infections 1 | 2
Retinal Hemorrhage 1 | 6
Retinal Neovascularization 1 | 4
Ridged nails 1 | 14
Skin Ulcer 1 | 48
Tooth Abnormalities 1 | 69
Uveitis 1 | 103
Warts 1 | 10
X- linked recessive 1 | 110
hypopigmented skin patch 1 | 59

Tissue

Blood and immune system 10 | 16,909
Cardiovascular System 10 | 15,192
Digestive Tract 10 | 17,369
Endocrine System 10 | 18,159
Female tissues 10 | 17,400
Liver and Pancreas 10 | 16,750
Respiratory system 10 | 16,393
Skin and soft tissues 10 | 17,230
Urinary Tract 10 | 16,678
Male tissues 9 | 17,142
Nervous System 9 | 16,725

Target Family

Epigenetic 3 | 242
Enzyme 2 | 4,145
Transcription Factor 2 | 1,400
Kinase 1 | 634
Non-IDG 1 | 12,091
Nuclear Receptor 1 | 48

GO Function

peroxisome proliferator activa... 10 | 10
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nuclear factor of activated T-cells, cytoplasmic 4 NFATC4 Tbio Transcription Factor -1.93766 88.3 358
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
Putative Polycomb group protein ASXL1 ASXL1 Tbio Epigenetic -2.25248 173.8 84
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.41690 2313.9 1252
Putative Polycomb group protein ASXL2 ASXL2 Tbio Epigenetic -1.23716 19.0 45
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha PPARGC1A Tbio Non-IDG -2.86449 728.1 274
High mobility group protein HMG-I/HMG-Y HMGA1 Tbio Transcription Factor -2.59141 433.8 253
Nuclear receptor subfamily 0 group B member 2 NR0B2 Tchem Nuclear Receptor -2.77179 598.3 299
Protein arginine N-methyltransferase 2 PRMT2 Tbio Epigenetic -1.20252 18.8 325
Mediator of RNA polymerase II transcription subunit 1 MED1 Tbio Enzyme -1.89424 83.3 350