Development Level

Tchem 12 | 1,598
Tclin 11 | 613
Tbio 4 | 11,445

Collection

GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

decreased bone mineral content 3 | 151
preweaning lethality, complete... 3 | 979
abnormal bone structure 2 | 187
decreased lean body mass 2 | 135
embryonic lethality prior to t... 2 | 278
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal heart morphology 1 | 162
abnormal liver morphology 1 | 17
abnormal sleep behavior 1 | 70
decreased IgE level 1 | 6
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
hyperactivity 1 | 148
hypoactivity 1 | 132
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating lipase l... 1 | 3
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased hemoglobin content 1 | 45
increased total body fat amoun... 1 | 134
long tibia 1 | 25
small testis 1 | 58
thrombocytopenia 1 | 56
urinary bladder obstruction 1 | 4

Disease

Carcinoma 21 | 11,493
psoriasis 12 | 6,694
ovarian cancer 11 | 8,520
ductal carcinoma in situ 9 | 1,745
lung carcinoma 9 | 2,843
breast carcinoma 8 | 1,638
invasive ductal carcinoma 8 | 2,951
lung cancer 8 | 4,740
lung adenocarcinoma 7 | 2,716
osteosarcoma 7 | 7,950
Autosomal recessive predisposition 6 | 1,442
Breast cancer 6 | 3,578
Hypertension 6 | 396
Obesity 6 | 678
diabetes mellitus 6 | 1,728
medulloblastoma, large-cell 6 | 6,241
Astrocytoma, Pilocytic 5 | 3,081
Autistic Disorder 5 | 364
Cancer 5 | 2,499
Kidney cancer 5 | 2,613
adult high grade glioma 5 | 3,801
cystic fibrosis 5 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
malignant mesothelioma 5 | 3,232
pancreatic cancer 5 | 2,398
Abdominal Pain 4 | 98
Acquired metabolic disease 4 | 336
Alcoholic Intoxication, Chronic 4 | 289
Depressive disorder 4 | 409
Heart disease 4 | 306
Short stature 4 | 531
adrenocortical carcinoma 4 | 1,428
colon cancer 4 | 1,478
ependymoma 4 | 4,679
group 4 medulloblastoma 4 | 1,855
head and neck cancer 4 | 271
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
nasopharyngeal carcinoma 4 | 1,058
non-small cell lung cancer 4 | 2,890
non-small cell lung carcinoma 4 | 317
oligodendroglioma 4 | 2,850
ulcerative colitis 4 | 1,819
Alcohol abuse 3 | 50
Congenital deafness 3 | 185
Deafness 3 | 198
Delayed bone age 3 | 136
Depressive Disorder, Major 3 | 19
Diabetes Mellitus, Non-Insulin-Dependent 3 | 145
Diabetes Mellitus, Type 2 3 | 142
Hearing Loss, Partial 3 | 185
Hypertensive disease 3 | 292
Hypoglycemia 3 | 152
Hypoplastic toes 3 | 29
Mental Depression 3 | 333
Prader-Willi syndrome 3 | 48
Schizophrenia 3 | 1,160
Short nose 3 | 132
Small nose 3 | 132
Weight decreased 3 | 103
astrocytoma 3 | 1,146
fibroadenoma 3 | 559
glioblastoma 3 | 5,792
group 3 medulloblastoma 3 | 4,104
hearing impairment 3 | 199
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pituitary cancer 3 | 1,972
tuberculosis 3 | 2,010
Acquired scoliosis 2 | 281
Atherosclerosis 2 | 291
Autism spectrum disorder 2 | 101
Bilateral fifth finger clinodactyly 2 | 110
Cannabis dependence 2 | 23
Concave bridge of nose 2 | 195
Constipation 2 | 181
Curvature of little finger 2 | 110
Curvature of spine 2 | 282
Decreased joint mobility 2 | 53
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Dwarfism 2 | 37
Dyschezia 2 | 135
Endometriosis 2 | 540
Epilepsy 2 | 792
Heart failure 2 | 162
Infertility 2 | 188
Kidney disease 2 | 430
Liver Cirrhosis, Experimental 2 | 769
Liver cancer 2 | 604
Major Depressive Disorder 2 | 301
Melanoma 2 | 711
Sensorineural Hearing Loss (disorder) 2 | 284
Short metacarpal 2 | 43
Type 2 diabetes mellitus 2 | 272
Unipolar Depression 2 | 250
active ulcerative colitis 2 | 764
adrenocortical adenoma 2 | 131
aldosterone-producing adenoma 2 | 665
pancreatic carcinoma 2 | 562
type II diabetes mellitus and post-ischemic heart failure 2 | 88

Tissue

Endocrine System 27 | 18,159
Female tissues 22 | 17,400
Skin and soft tissues 22 | 17,230
Urinary Tract 22 | 16,678
Blood and immune system 21 | 16,909
Liver and Pancreas 21 | 16,750
Nervous System 21 | 16,725
Digestive Tract 20 | 17,369
Male tissues 20 | 17,142
Respiratory system 20 | 16,393
Cardiovascular System 18 | 15,192

Target Family

GPCR 18 | 408
Non-IDG 4 | 12,091
Kinase 3 | 634
Enzyme 1 | 4,145
Transporter 1 | 473

GO Function

peptide hormone binding 27 | 27
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Relaxin receptor 2 RXFP2 Tbio GPCR -1.97913 85.3 207
Melanocortin receptor 3 MC3R Tchem GPCR -2.65556 445.3 202
Orexin receptor type 1 HCRTR1 Tclin GPCR -2.20503 162.0 294
Growth hormone secretagogue receptor type 1 GHSR Tclin GPCR -2.70721 350.2 181
Melanocortin receptor 4 MC4R Tchem GPCR -2.95116 930.2 251
Growth hormone-releasing hormone receptor GHRHR Tclin GPCR -2.10486 138.0 205
Atrial natriuretic peptide receptor 1 NPR1 Tclin Kinase -2.61776 410.0 214
Oxytocin receptor OXTR Tclin GPCR -2.90022 820.8 255
Type-2 angiotensin II receptor AGTR2 Tchem GPCR -3.30172 1972.1 147