Development Level

Tchem 23 | 1,388
Tbio 21 | 11,651
Tclin 11 | 612
Tdark 3 | 6,593

Collection

GPCR: IDG Consortium (Targets) 4 | 126
GPCR: IDG Consortium (Complete... 2 | 25
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal gait 2 | 69
decreased circulating choleste... 2 | 93
decreased total body fat amoun... 2 | 207
embryonic lethality prior to t... 2 | 278
hyperactivity 2 | 148
abnormal behavior 1 | 298
abnormal body wall morphology 1 | 9
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal facial morphology 1 | 17
abnormal hair texture 1 | 4
abnormal heart morphology 1 | 162
abnormal incisor morphology 1 | 4
abnormal limb bud morphology 1 | 17
abnormal limb morphology 1 | 13
abnormal maxilla morphology 1 | 17
abnormal neural tube closure 1 | 46
abnormal tail morphology 1 | 25
abnormal vibrissa morphology 1 | 25
brachydactyly 1 | 19
cleft palate 1 | 8
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
decreased total retina thickne... 1 | 17
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
hemorrhage 1 | 23
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased bone mineral density 1 | 72
increased circulating amylase ... 1 | 25
increased circulating creatini... 1 | 38
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
thrombocytopenia 1 | 56
thrombocytosis 1 | 27

Disease

Carcinoma 41 | 11,493
osteosarcoma 32 | 7,950
ovarian cancer 27 | 8,520
psoriasis 25 | 6,694
lung cancer 19 | 4,740
medulloblastoma, large-cell 19 | 6,241
atypical teratoid / rhabdoid tumor 18 | 5,112
ependymoma 18 | 4,679
glioblastoma 18 | 5,792
invasive ductal carcinoma 17 | 2,951
Cancer 15 | 2,499
ductal carcinoma in situ 15 | 1,745
malignant mesothelioma 15 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
non-small cell lung cancer 13 | 2,890
Astrocytoma, Pilocytic 12 | 3,081
Breast cancer 12 | 3,578
Kidney cancer 12 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
adult high grade glioma 11 | 3,801
breast carcinoma 11 | 1,638
group 3 medulloblastoma 11 | 4,104
lung adenocarcinoma 11 | 2,716
lung carcinoma 10 | 2,843
pancreatic cancer 10 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
Schizophrenia 9 | 1,160
acute quadriplegic myopathy 9 | 1,158
oligodendroglioma 9 | 2,850
primitive neuroectodermal tumor 9 | 3,035
Hypertension 8 | 396
astrocytoma 8 | 1,146
group 4 medulloblastoma 8 | 1,855
tuberculosis 8 | 2,010
ulcerative colitis 8 | 1,819
astrocytic glioma 7 | 2,597
interstitial cystitis 7 | 2,312
pituitary cancer 7 | 1,972
Alzheimer's disease 6 | 658
Atopic dermatitis 6 | 952
Bipolar Disorder 6 | 666
Depressive disorder 6 | 409
Major Depressive Disorder 6 | 301
Pain agnosia 6 | 104
Prostatic Neoplasms 6 | 495
Unipolar Depression 6 | 250
active Crohn's disease 6 | 922
colon cancer 6 | 1,478
cystic fibrosis 6 | 1,696
spina bifida 6 | 1,074
Hypertensive disease 5 | 292
Multiple myeloma 5 | 1,332
Waldenstrons macroglobulinemia 5 | 765
acute myeloid leukemia 5 | 783
adrenocortical carcinoma 5 | 1,428
cutaneous lupus erythematosus 5 | 1,057
diabetes mellitus 5 | 1,728
esophageal adenocarcinoma 5 | 737
pediatric high grade glioma 5 | 1,064
Acquired metabolic disease 4 | 336
Asthma 4 | 385
Kidney disease 4 | 430
Liver Cirrhosis, Experimental 4 | 769
Melanoma 4 | 711
Mental Depression 4 | 333
Mood Disorders 4 | 184
Obesity 4 | 678
Rheumatoid arthritis 4 | 1,191
fibroadenoma 4 | 559
juvenile dermatomyositis 4 | 1,187
non primary Sjogren syndrome sicca 4 | 891
primary pancreatic ductal adenocarcinoma 4 | 1,109
Alzheimer Disease 3 | 83
Amyotrophic lateral sclerosis 3 | 451
Arthritis 3 | 290
Atherosclerosis 3 | 291
Autism spectrum disorder 3 | 101
Autistic Disorder 3 | 364
Autosomal recessive predisposition 3 | 1,442
Dull intelligence 3 | 645
Endometriosis 3 | 540
Low intelligence 3 | 645
Mammary Neoplasms, Experimental 3 | 154
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Multiple Sclerosis 3 | 540
Neurodegenerative disease 3 | 414
Osteoporosis 3 | 363
Pick disease 3 | 1,894
Polycystic ovary syndrome 3 | 360
Poor school performance 3 | 645
active ulcerative colitis 3 | 764
gastric carcinoma 3 | 807
glioblastoma multiforme 3 | 142
head and neck cancer 3 | 271
nasopharyngeal carcinoma 3 | 1,058
nephrosclerosis 3 | 333
pancreatic carcinoma 3 | 562
subependymal giant cell astrocytoma 3 | 2,287

Tissue

Endocrine System 56 | 18,159
Nervous System 54 | 16,725
Digestive Tract 53 | 17,369
Female tissues 53 | 17,400
Male tissues 53 | 17,142
Skin and soft tissues 53 | 17,230
Urinary Tract 53 | 16,678
Liver and Pancreas 52 | 16,750
Blood and immune system 51 | 16,909
Cardiovascular System 48 | 15,192
Respiratory system 47 | 16,393

Target Family

Enzyme 25 | 4,145
GPCR 17 | 408
Non-IDG 9 | 12,091
Kinase 4 | 634
Nuclear Receptor 2 | 48
Transcription Factor 1 | 1,400

GO Function

peptide binding 58 | 58
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Neuropeptide FF receptor 2 NPFFR2 Tchem GPCR -1.63803 38.0 161
Thyrotropin-releasing hormone-degrading ectoenzyme TRHDE Tbio Enzyme -1.62910 39.1 51
Gonadotropin-releasing hormone receptor GNRHR Tclin GPCR -2.63054 444.8 313
Leucyl-cystinyl aminopeptidase LNPEP Tchem Enzyme -2.57244 394.0 103
Calreticulin CALR Tbio Non-IDG -3.19563 1544.2 778
Orexin receptor type 2 HCRTR2 Tclin GPCR -1.47750 26.3 249
Endoplasmic reticulum aminopeptidase 1 ERAP1 Tchem Enzyme -2.32434 221.0 216
Glutamyl aminopeptidase ENPEP Tchem Enzyme -2.81719 655.7 311
Neurolysin, mitochondrial NLN Tbio Enzyme -2.71715 516.7 120
Vasopressin V1a receptor AVPR1A Tclin GPCR -2.33425 215.7 181