Development Level

Tbio 95 | 11,445
Tdark 6 | 6,588
Tchem 2 | 1,598

IMPC Phenotype

abnormal behavior 1 | 298
decreased blood urea nitrogen ... 1 | 51
decreased circulating triglyce... 1 | 79
increased startle reflex 1 | 112
preweaning lethality, complete... 1 | 979

Disease

Cancer 77 | 2,499
Ankylosing spondylitis 71 | 140
Behcet's disease 70 | 89
diabetes mellitus 67 | 1,728
Juvenile rheumatoid arthritis 63 | 111
Hypersensitivity reaction type II disease 62 | 253
psoriasis 59 | 6,694
Arthritis 57 | 290
Uveitis 57 | 103
Acquired immunodeficiency syndrome 56 | 197
Herpes zoster 56 | 68
Psoriatic arthritis 52 | 86
Human immunodeficiency virus infectious disease 51 | 138
Stevens-Johnson syndrome 50 | 92
Rheumatoid arthritis 47 | 1,191
Carcinoma 44 | 11,493
dermatomyositis 42 | 966
Dermatitis 36 | 157
Behcet's syndrome 35 | 50
Congenital adrenal hyperplasia 35 | 73
Nephritis 35 | 51
Retinal vasculitis 35 | 36
Spondyloarthropathy, Susceptibility To, 1 35 | 35
Synovitis 35 | 78
Takayasu's arteritis 35 | 53
drug-induced hepatitis 35 | 44
Multiple Sclerosis 31 | 540
tuberculosis 28 | 2,010
Hepatitis B 26 | 108
Leprosy 25 | 73
Liver disease 24 | 237
Anemia 22 | 365
Hemochromatosis 22 | 54
Kidney disease 22 | 430
Birdshot chorioretinopathy 21 | 23
Primary immunodeficiency disease 21 | 54
Skin disease 21 | 66
ovarian cancer 16 | 8,520
Human immunodeficiency virus type 1, susceptibility to 15 | 26
Pre-Eclampsia 15 | 68
lung cancer 15 | 4,740
Psoriasis susceptibility 1 14 | 14
glioblastoma 12 | 5,792
lung carcinoma 12 | 2,843
Narcolepsy 10 | 72
breast carcinoma 10 | 1,638
invasive ductal carcinoma 10 | 2,951
juvenile dermatomyositis 10 | 1,187
subependymal giant cell astrocytoma 10 | 2,287
Astrocytoma, Pilocytic 9 | 3,081
Berylliosis 9 | 28
Schizophrenia 9 | 1,160
sarcoidosis 9 | 370
Multiple Sclerosis, Susceptibility to 8 | 15
Narcolepsy-cataplexy 8 | 21
Systemic lupus erythematosus 8 | 194
astrocytoma 8 | 1,146
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
Diffuse cutaneous systemic sclerosis 7 | 17
Rheumatoid Arthritis, Systemic Juvenile 7 | 16
Sarcoidosis 1 7 | 14
active Crohn's disease 7 | 922
adult high grade glioma 7 | 3,801
follicular lymphoma 7 | 20
interstitial cystitis 7 | 2,312
limited scleroderma 7 | 19
osteosarcoma 7 | 7,950
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Duchenne muscular dystrophy 6 | 601
Type 1 diabetes mellitus 6 | 109
active ulcerative colitis 6 | 764
esophageal adenocarcinoma 6 | 737
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
non-small cell lung cancer 6 | 2,890
primary Sjogren syndrome 6 | 735
Asthma 5 | 385
Hypersensitivity 5 | 63
Multiple myeloma 5 | 1,332
Vasculitis 5 | 80
cutaneous lupus erythematosus 5 | 1,057
ductal carcinoma in situ 5 | 1,745
ependymoma 5 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
medulloblastoma, large-cell 5 | 6,241
pituitary cancer 5 | 1,972
posterior fossa group A ependymoma 5 | 468
Addison's disease 4 | 31
Autoimmune thyroiditis 4 | 27
Autosomal recessive predisposition 4 | 1,442
Breast cancer 4 | 3,578
Chemical and Drug Induced Liver Injury 4 | 195
Graves' disease 4 | 24
Proteinuria 4 | 144
Skin Ulcer 4 | 48
Weight decreased 4 | 103
astrocytic glioma 4 | 2,597
colon cancer 4 | 1,478
malignant mesothelioma 4 | 3,232
oligodendroglioma 4 | 2,850
pancreatic cancer 4 | 2,398

Tissue

Digestive Tract 20 | 17,369
Endocrine System 20 | 18,159
Female tissues 20 | 17,400
Liver and Pancreas 20 | 16,750
Respiratory system 20 | 16,393
Blood and immune system 19 | 16,909
Skin and soft tissues 19 | 17,230
Urinary Tract 19 | 16,678
Cardiovascular System 18 | 15,192
Male tissues 18 | 17,142
Nervous System 18 | 16,725

Target Family

Non-IDG 99 | 12,091
Transporter 3 | 473
Enzyme 1 | 4,145

GO Function

peptide antigen binding 103 | 103
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

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