Development Level

Tbio 29 | 10,625
Tchem 27 | 1,890
Tdark 10 | 7,003
Tclin 4 | 602

IMPC Term

preweaning lethality, complete... 4 | 633
increased monocyte cell number 3 | 27
decreased body length 2 | 108
decreased bone mineral content 2 | 157
decreased lean body mass 2 | 195
embryonic lethality prior to t... 2 | 187
increased circulating alkaline... 2 | 119
abnormal behavior 1 | 226
abnormal body wall morphology 1 | 7
abnormal bone structure 1 | 131
abnormal embryo size 1 | 112
abnormal facial morphology 1 | 9
abnormal limb bud morphology 1 | 15
abnormal limb morphology 1 | 7
abnormal neural tube closure 1 | 37
abnormal tail morphology 1 | 17
abnormal vibrissa morphology 1 | 17
abnormal vocalization 1 | 21
brachydactyly 1 | 2
cleft palate 1 | 6
decreased CD4-positive, alpha ... 1 | 19
decreased KLRG1-positive NK ce... 1 | 9
decreased NK T cell number 1 | 28
decreased T cell number 1 | 31
decreased alpha-beta T cell nu... 1 | 12
decreased body weight 1 | 174
decreased bone mineral density 1 | 126
decreased circulating amylase ... 1 | 24
decreased circulating fructosa... 1 | 31
decreased circulating glucose ... 1 | 121
decreased effector memory CD4-... 1 | 6
decreased effector memory CD8-... 1 | 24
decreased gamma-delta T cell n... 1 | 18
decreased total body fat amoun... 1 | 186
embryonic growth retardation 1 | 28
female infertility 1 | 34
hemorrhage 1 | 12
hyperactivity 1 | 108
impaired glucose tolerance 1 | 52
increased B cell number 1 | 23
increased CD8-positive, alpha-... 1 | 11
increased KLRG1-positive NK ce... 1 | 9
increased Ly6C high monocyte n... 1 | 12
increased Ly6C low monocyte nu... 1 | 8
increased NK cell number 1 | 19
increased anxiety-related resp... 1 | 1
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating bilirubi... 1 | 16
increased circulating iron lev... 1 | 25
increased effector memory CD4-... 1 | 15
increased eosinophil cell numb... 1 | 9
increased leukocyte cell numbe... 1 | 37
increased mature B cell number 1 | 12
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
limb grasping 1 | 35
male infertility 1 | 62
short tibia 1 | 82
thrombocytopenia 1 | 46

Disease

ovarian cancer 33 | 8,484
psoriasis 31 | 6,685
osteosarcoma 29 | 7,933
Cancer 21 | 2,346
lung cancer 17 | 4,466
glioblastoma 16 | 5,572
medulloblastoma, large-cell 15 | 6,234
Breast cancer 14 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,289
malignant mesothelioma 13 | 3,162
non-small cell lung cancer 13 | 2,798
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,795
ependymoma 12 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,956
invasive ductal carcinoma 12 | 2,950
ulcerative colitis 12 | 2,087
atypical teratoid / rhabdoid tumor 11 | 4,369
subependymal giant cell astrocytoma 11 | 2,287
Alzheimer's disease 10 | 644
diabetes mellitus 10 | 1,663
lung carcinoma 10 | 2,844
oligodendroglioma 10 | 2,849
pancreatic cancer 10 | 2,300
cutaneous lupus erythematosus 9 | 1,056
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,988
active Crohn's disease 8 | 918
lung adenocarcinoma 8 | 2,713
pediatric high grade glioma 8 | 2,712
tuberculosis 8 | 1,557
Multiple myeloma 7 | 1,327
Parkinson's disease 7 | 364
astrocytic glioma 7 | 2,241
astrocytoma 7 | 1,493
cystic fibrosis 7 | 1,665
Carcinoma 6 | 2,147
Prostatic Neoplasms 6 | 471
Waldenstrons macroglobulinemia 6 | 765
breast carcinoma 6 | 1,614
esophageal adenocarcinoma 6 | 737
interstitial cystitis 6 | 2,299
pituitary cancer 6 | 1,972
posterior fossa group B ependymoma 6 | 1,530
Atopic dermatitis 5 | 944
Neurodegenerative disease 5 | 383
Pancreatitis 5 | 97
Pick disease 5 | 1,893
Toxic encephalopathy 5 | 131
adrenocortical carcinoma 5 | 1,427
gastric carcinoma 5 | 832
group 3 medulloblastoma 5 | 2,254
group 4 medulloblastoma 5 | 1,875
medulloblastoma 5 | 1,524
primitive neuroectodermal tumor 5 | 3,031
Arthritis 4 | 248
Down syndrome 4 | 548
Duchenne muscular dystrophy 4 | 602
Lung disease 4 | 132
Myopathy 4 | 128
Vascular disease 4 | 281
acute myeloid leukemia 4 | 780
atypical teratoid/rhabdoid tumor 4 | 1,095
dermatomyositis 4 | 933
fibroadenoma 4 | 557
pilocytic astrocytoma 4 | 3,086
primary pancreatic ductal adenocarcinoma 4 | 1,271
progressive supranuclear palsy 4 | 674
spina bifida 4 | 1,064
Amyotrophic lateral sclerosis type 3 3 | 15
Atherosclerosis 3 | 275
Brain disease 3 | 83
Cerebrovascular disease 3 | 231
Edema 3 | 38
Myocardial Infarction 3 | 126
Myocardial Reperfusion Injury 3 | 34
Netherton syndrome 3 | 14
Osteoporosis 3 | 257
Proteinuria 3 | 63
active ulcerative colitis 3 | 477
acute quadriplegic myopathy 3 | 1,157
juvenile dermatomyositis 3 | 1,189
nasopharyngeal carcinoma 3 | 1,056
nephrosclerosis 3 | 329
non-inflammatory breast cancer 3 | 208
posterior fossa group A ependymoma 3 | 1,511
Brain Ischemia 2 | 87
Cardiovascular Diseases 2 | 50
Dermatitis 2 | 107
Dermatitis, Allergic Contact 2 | 66
Diabetes Mellitus, Non-Insulin-Dependent 2 | 157
Hypertension 2 | 287
Multiple Sclerosis 2 | 498
Peripheral Neuropathy 2 | 303
Prostate cancer 2 | 172
Reperfusion Injury 2 | 84
Synostosis 2 | 18
adult high grade glioma 2 | 2,148
colon cancer 2 | 1,475
head and neck cancer 2 | 270
inflammatory breast cancer 2 | 404
mucosa-associated lymphoid tissue lymphoma 2 | 480

Tissue

Blood and immune system 70 | 17,995
Digestive Tract 70 | 18,473
Endocrine System 70 | 18,512
Female tissues 70 | 18,647
Liver and Pancreas 70 | 18,136
Male tissues 70 | 17,969
Nervous System 70 | 18,561
Skin and soft tissues 70 | 18,115
Urinary Tract 70 | 18,444
Cardiovascular System 69 | 17,958
Respiratory system 68 | 17,484

Target Family

Enzyme 57 | 4,146
Non-IDG 12 | 11,971
Transcription Factor 1 | 1,400

GO Function

peptidase activity 70 | 70
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
N-acetylated-alpha-linked acidic dipeptidase-like protein NAALADL1 Tbio Enzyme -1.30374 25.3 78
Bone morphogenetic protein 1 BMP1 Tchem Non-IDG -2.32178 220.1 155
A disintegrin and metalloproteinase with thrombospondin motifs 4 ADAMTS4 Tchem Enzyme -1.59386 46.6 337
Astacin-like metalloendopeptidase ASTL Tbio Enzyme -1.22853 19.6 20
Kallikrein-7 KLK7 Tchem Enzyme -2.07784 133.2 260
Lon protease homolog 2, peroxisomal LONP2 Tdark Enzyme -0.53577 3.84 86
Desumoylating isopeptidase 2 DESI2 Tbio Enzyme -2.72756 582.2 66
Ubiquitin carboxyl-terminal hydrolase isozyme L3 UCHL3 Tchem Enzyme -2.06113 117.5 237
Kyphoscoliosis peptidase KY Tdark Enzyme -0.06695 1.14 58
Pepsin A-5 PGA5 Tclin Enzyme -1.95372 87.1 86