Development Level

Tbio 37 | 11,651
Tchem 26 | 1,388
Tdark 13 | 6,593
Tclin 4 | 612

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal behavior 2 | 298
decreased circulating HDL chol... 2 | 68
decreased circulating choleste... 2 | 93
decreased lean body mass 2 | 135
embryonic lethality prior to t... 2 | 278
increased total body fat amoun... 2 | 134
abnormal body wall morphology 1 | 9
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal facial morphology 1 | 17
abnormal lens morphology 1 | 81
abnormal limb bud morphology 1 | 17
abnormal limb morphology 1 | 13
abnormal neural tube closure 1 | 46
abnormal placement of pupils 1 | 6
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal tail morphology 1 | 25
abnormal vibrissa morphology 1 | 25
abnormal vocalization 1 | 21
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
cleft palate 1 | 8
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased fasted circulating g... 1 | 65
decreased lymphocyte cell numb... 1 | 83
decreased mean platelet volume 1 | 25
decreased red blood cell distr... 1 | 41
embryonic growth retardation 1 | 106
hemorrhage 1 | 23
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased anxiety-related resp... 1 | 2
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating iron lev... 1 | 30
increased circulating serum al... 1 | 22
increased heart rate variabili... 1 | 7
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
limb grasping 1 | 41
long tibia 1 | 25
male infertility 1 | 123
persistence of hyaloid vascula... 1 | 33
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
thrombocytopenia 1 | 56

Disease

Carcinoma 48 | 11,493
ovarian cancer 38 | 8,520
psoriasis 35 | 6,694
osteosarcoma 32 | 7,950
Cancer 23 | 2,499
lung cancer 21 | 4,740
ependymoma 20 | 4,679
glioblastoma 19 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,291
medulloblastoma, large-cell 19 | 6,241
Breast cancer 18 | 3,578
atypical teratoid / rhabdoid tumor 18 | 5,112
malignant mesothelioma 16 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
Autosomal recessive predisposition 15 | 1,442
group 3 medulloblastoma 15 | 4,104
invasive ductal carcinoma 14 | 2,951
non-small cell lung cancer 14 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
lung carcinoma 13 | 2,843
pancreatic cancer 13 | 2,398
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
subependymal giant cell astrocytoma 12 | 2,287
Alzheimer's disease 11 | 658
diabetes mellitus 11 | 1,728
oligodendroglioma 11 | 2,850
lung adenocarcinoma 10 | 2,716
ulcerative colitis 10 | 1,819
Multiple myeloma 9 | 1,332
active Crohn's disease 9 | 922
astrocytic glioma 9 | 2,597
cutaneous lupus erythematosus 9 | 1,057
interstitial cystitis 9 | 2,312
pediatric high grade glioma 9 | 1,064
Waldenstrons macroglobulinemia 8 | 765
cystic fibrosis 8 | 1,696
Parkinson's disease 7 | 392
Prostatic Neoplasms 7 | 495
esophageal adenocarcinoma 7 | 737
primitive neuroectodermal tumor 7 | 3,035
tuberculosis 7 | 2,010
Astrocytoma, Pilocytic 6 | 3,081
Pick disease 6 | 1,894
Toxic encephalopathy 6 | 141
active ulcerative colitis 6 | 764
adrenocortical carcinoma 6 | 1,428
astrocytoma 6 | 1,146
breast carcinoma 6 | 1,638
dermatomyositis 6 | 966
gastric carcinoma 6 | 807
pituitary cancer 6 | 1,972
Atopic dermatitis 5 | 952
Liver Cirrhosis, Experimental 5 | 769
Neurodegenerative disease 5 | 414
Pancreatitis 5 | 123
Small head 5 | 374
acute myeloid leukemia 5 | 783
adult high grade glioma 5 | 3,801
fibroadenoma 5 | 559
group 4 medulloblastoma 5 | 1,855
juvenile dermatomyositis 5 | 1,187
primary pancreatic ductal adenocarcinoma 5 | 1,109
Acquired scoliosis 4 | 281
Arthritis 4 | 290
Curvature of spine 4 | 282
Down syndrome 4 | 499
Duchenne muscular dystrophy 4 | 601
Epilepsy 4 | 792
Lung disease 4 | 142
Myocardial Reperfusion Injury 4 | 37
Myopathy 4 | 185
Obesity 4 | 678
Schizophrenia 4 | 1,160
Short stature 4 | 531
Vascular disease 4 | 319
acute quadriplegic myopathy 4 | 1,158
colon cancer 4 | 1,478
progressive supranuclear palsy 4 | 676
spina bifida 4 | 1,074
Anemia 3 | 365
Atherosclerosis 3 | 291
Bilateral fifth finger clinodactyly 3 | 110
Bipolar Disorder 3 | 666
Carcinoma, Hepatocellular 3 | 228
Cerebrovascular disease 3 | 238
Craniosynostosis 3 | 74
Curvature of little finger 3 | 110
Dementia 3 | 175
Depressive disorder 3 | 409
Hemoglobin low 3 | 124
Kidney cancer 3 | 2,613
Liver carcinoma 3 | 240
Melanoma 3 | 711
Mental Depression 3 | 333
Multiple Sclerosis 3 | 540
Seizures 3 | 596
Type 2 diabetes mellitus 3 | 272
mucosa-associated lymphoid tissue lymphoma 3 | 484
nasopharyngeal carcinoma 3 | 1,058
nephrosclerosis 3 | 333

Tissue

Endocrine System 79 | 18,159
Digestive Tract 78 | 17,369
Female tissues 78 | 17,400
Skin and soft tissues 78 | 17,230
Respiratory system 77 | 16,393
Blood and immune system 76 | 16,909
Liver and Pancreas 76 | 16,750
Male tissues 76 | 17,142
Urinary Tract 76 | 16,678
Nervous System 73 | 16,725
Cardiovascular System 64 | 15,192

Target Family

Enzyme 66 | 4,145
Non-IDG 13 | 12,091
Transcription Factor 1 | 1,400

GO Function

peptidase activity 80 | 80
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Kallikrein-12 KLK12 Tbio Enzyme -0.99694 11.0 111
Desumoylating isopeptidase 2 DESI2 Tbio Enzyme -2.81944 648.8 75
Chymotrypsin-C CTRC Tchem Enzyme -2.46349 293.5 81
Ubiquitin carboxyl-terminal hydrolase 1 USP1 Tchem Enzyme -1.88853 73.3 271
Gamma-secretase subunit APH-1B APH1B Tbio Enzyme -1.17035 13.6 56
Desert hedgehog protein DHH Tbio Non-IDG -2.26501 171.2 318
Bone morphogenetic protein 1 BMP1 Tchem Non-IDG -2.35499 232.7 208
Signal peptidase complex catalytic subunit SEC11C SEC11C Tdark Enzyme -0.46982 3.63 31
Thrombospondin type-1 domain-containing protein 4 THSD4 Tdark Non-IDG -0.62904 3.69 5
Ubiquitin carboxyl-terminal hydrolase isozyme L3 UCHL3 Tchem Enzyme -2.08846 121.1 247