Development Level

Tbio 6 | 11,445
Tchem 3 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

improved glucose tolerance 1 | 79
increased circulating iron lev... 1 | 30
vertebral fusion 1 | 23

Disease

medulloblastoma, large-cell 5 | 6,241
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
invasive ductal carcinoma 4 | 2,951
osteosarcoma 4 | 7,950
ovarian cancer 4 | 8,520
Breast cancer 3 | 3,578
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
subependymal giant cell astrocytoma 3 | 2,287
Autosomal recessive predisposition 2 | 1,442
Carcinoma 2 | 11,493
Cerebellar Ataxia 2 | 304
Multiple myeloma 2 | 1,332
Muscle Spasticity 2 | 195
Neuronal ceroid lipofuscinosis 2 | 28
Obesity 2 | 678
Optic Atrophy 2 | 242
Rheumatoid arthritis 2 | 1,191
astrocytoma 2 | 1,146
ductal carcinoma in situ 2 | 1,745
group 4 medulloblastoma 2 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
lung cancer 2 | 4,740
malignant mesothelioma 2 | 3,232
pancreatic cancer 2 | 2,398
psoriasis 2 | 6,694
tuberculosis 2 | 2,010
Abnormality of metabolism/homeostasis 1 | 134
Amnestic disorder 1 | 35
Astrocytoma, Pilocytic 1 | 3,081
Atrophy of cerebellum 1 | 103
Babinski Reflex 1 | 100
Barth syndrome 1 | 23
Blind Vision 1 | 111
Blindness 1 | 88
Blindness, Legal 1 | 110
Cerebellar Dysmetria 1 | 56
Cerebellar degeneration 1 | 103
Cerebral atrophy 1 | 178
Congenital pes cavus 1 | 88
Contracture 1 | 96
Contracture of joint 1 | 93
Decreased nerve conduction velocity 1 | 35
Decreased tendon reflex 1 | 122
Decreased visual acuity, progressive 1 | 36
Degenerative brain disorder 1 | 100
Depressive disorder 1 | 409
Diarrhea 1 | 253
Distal amyotrophy 1 | 51
Distal sensory impairment 1 | 52
Duchenne muscular dystrophy 1 | 601
Dysarthria 1 | 192
Electroencephalogram abnormal 1 | 101
Epilepsy 1 | 792
Extinguished electroretinogram 1 | 15
Fatty liver disease 1 | 103
Flexion contracture 1 | 93
Flexion contractures of joints 1 | 93
Hallucinations 1 | 34
Hallucinations, Sensory 1 | 33
Highly variable clinical phenotype 1 | 150
Highly variable phenotype and severity 1 | 150
Highly variable phenotype, even within families 1 | 150
Hyperreflexia 1 | 209
Increased neuronal autofluorescent lipopigment 1 | 7
Infratentorial atrophy 1 | 103
Loss of speech 1 | 16
Macular degeneration 1 | 65
Myoclonus 1 | 74
Neurodegenerative disease 1 | 414
Neuronal lipopigments 1 | 7
Neuropathy 1 | 261
Peripheral Neuropathy 1 | 134
Peripheral sensorimotor neuropathy 1 | 16
Phenotypic variability 1 | 150
Pick disease 1 | 1,894
Progressive microcephaly 1 | 32
Progressive visual loss 1 | 36
Retinal Degeneration 1 | 106
Seizures 1 | 596
Sengers syndrome 1 | 18
Sensorineural Hearing Loss (disorder) 1 | 284
Sleep disturbances 1 | 37
Slow progression 1 | 89
Spastic Quadriplegia 1 | 42
Supratentorial atrophy 1 | 94
Waldenstrons macroglobulinemia 1 | 765
acute myeloid leukemia 1 | 783
adult high grade glioma 1 | 3,801
breast carcinoma 1 | 1,638
chronic lymphosyte leukemia 1 | 204
diabetes mellitus 1 | 1,728
hepatocellular carcinoma 1 | 547
hereditary spastic paraplegia 1 | 318
juvenile dermatomyositis 1 | 1,187
lung adenocarcinoma 1 | 2,716
non-small cell lung cancer 1 | 2,890
pancreatic carcinoma 1 | 562
progressive supranuclear palsy 1 | 676
spina bifida 1 | 1,074
tuberculosis and treatment for 3 months 1 | 179

Tissue

Blood and immune system 10 | 16,909
Cardiovascular System 10 | 15,192
Digestive Tract 10 | 17,369
Endocrine System 10 | 18,159
Female tissues 10 | 17,400
Liver and Pancreas 10 | 16,750
Male tissues 10 | 17,142
Nervous System 10 | 16,725
Respiratory system 10 | 16,393
Skin and soft tissues 10 | 17,230
Urinary Tract 10 | 16,678

Target Family

Enzyme 10 | 4,145

GO Function

palmitoyl-(protein) hydrolase ... 10 | 10
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Palmitoyl-protein thioesterase 1 PPT1 Tbio Enzyme -2.63966 433.8 305
Lysosomal thioesterase PPT2 PPT2 Tbio Enzyme -2.06846 111.8 104
Protein ABHD13 ABHD13 Tdark Enzyme 0.00000 81
Lysophospholipase-like protein 1 LYPLAL1 Tbio Enzyme -1.18623 14.4 127
Protein ABHD17B ABHD17B Tbio Enzyme 0.00000 28
Acyl-protein thioesterase 1 LYPLA1 Tchem Enzyme -1.83454 68.8 214
Acyl-protein thioesterase 2 LYPLA2 Tchem Enzyme -1.00114 10.4 122
Protein ABHD17C ABHD17C Tbio Enzyme 0.00000 56
Monoacylglycerol lipase ABHD12 ABHD12 Tchem Enzyme -1.27115 18.3 143
Protein ABHD17A ABHD17A Tbio Enzyme -0.31157 1.76 24