Development Level

Tbio 37 | 11,445
Tchem 28 | 1,598
Tdark 5 | 6,588
Tclin 2 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 9 | 979
abnormal behavior 5 | 298
increased lean body mass 3 | 172
abnormal lens morphology 2 | 81
abnormal retinal blood vessel ... 2 | 26
abnormal retinal vasculature m... 2 | 27
cataract 2 | 92
decreased circulating LDL chol... 2 | 38
decreased vertical activity 2 | 208
hypoactivity 2 | 132
increased circulating HDL chol... 2 | 80
abnormal coat- hair morphology 1 | 19
abnormal embryo size 1 | 220
abnormal facial morphology 1 | 17
abnormal heart left ventricle ... 1 | 16
abnormal iris morphology 1 | 13
abnormal liver morphology 1 | 17
abnormal optic disc morphology 1 | 10
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
cardiovascular system phenotyp... 1 | 36
cleft palate 1 | 8
corneal opacity 1 | 32
cyanosis 1 | 7
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged spleen 1 | 41
hemorrhage 1 | 23
hyperactivity 1 | 148
impaired pupillary reflex 1 | 26
improved glucose tolerance 1 | 79
increased blood uric acid leve... 1 | 5
increased circulating LDL chol... 1 | 13
increased circulating choleste... 1 | 66
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased mean platelet volume 1 | 45
increased neutrophil cell numb... 1 | 46
irregularly shaped pupil 1 | 7
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
small heart 1 | 10
small kidney 1 | 16
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 19
tremors 1 | 39

Disease

Carcinoma 55 | 11,493
ovarian cancer 44 | 8,520
osteosarcoma 42 | 7,950
Cancer 35 | 2,499
lung cancer 33 | 4,740
glioblastoma 25 | 5,792
medulloblastoma, large-cell 25 | 6,241
psoriasis 25 | 6,694
Breast cancer 22 | 3,578
atypical teratoid / rhabdoid tumor 21 | 5,112
ependymoma 21 | 4,679
Kidney cancer 18 | 2,613
oligodendroglioma 18 | 2,850
adult high grade glioma 16 | 3,801
astrocytic glioma 15 | 2,597
group 3 medulloblastoma 15 | 4,104
malignant mesothelioma 15 | 3,232
Astrocytoma, Pilocytic 14 | 3,081
invasive ductal carcinoma 14 | 2,951
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
primitive neuroectodermal tumor 13 | 3,035
juvenile dermatomyositis 12 | 1,187
non-small cell lung cancer 12 | 2,890
Intellectual disability 11 | 1,016
Multiple myeloma 11 | 1,332
breast carcinoma 11 | 1,638
diabetes mellitus 11 | 1,728
pancreatic cancer 11 | 2,398
acute quadriplegic myopathy 10 | 1,158
Alzheimer's disease 9 | 658
Breast Neoplasms 9 | 445
Epilepsy 9 | 792
Lung Neoplasms 9 | 232
Pick disease 9 | 1,894
Rheumatoid arthritis 9 | 1,191
ductal carcinoma in situ 9 | 1,745
group 4 medulloblastoma 9 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
lung adenocarcinoma 9 | 2,716
lung carcinoma 9 | 2,843
subependymal giant cell astrocytoma 9 | 2,287
Amyotrophic lateral sclerosis 8 | 451
Schizophrenia 8 | 1,160
Seizures 8 | 596
Squamous cell carcinoma 8 | 129
adrenocortical carcinoma 8 | 1,428
astrocytoma 8 | 1,146
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
Carcinoma, Squamous Cell 7 | 110
Cryptorchidism 7 | 296
Mammary Neoplasms 7 | 425
Muscle hypotonia 7 | 571
Pancreatic Neoplasm 7 | 85
Prostatic Neoplasms 7 | 495
Short stature 7 | 531
Waldenstrons macroglobulinemia 7 | 765
colon cancer 7 | 1,478
dermatomyositis 7 | 966
interstitial cystitis 7 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
pituitary cancer 7 | 1,972
spina bifida 7 | 1,074
tuberculosis 7 | 2,010
Adenocarcinoma 6 | 122
Bipolar Disorder 6 | 666
Bushy eyebrows 6 | 49
Dull intelligence 6 | 645
Immune system cancer 6 | 140
Low intelligence 6 | 645
Lymphoid leukemia 6 | 160
Melanoma 6 | 711
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Mood Disorders 6 | 184
Neoplasm Invasiveness 6 | 161
Neurodegenerative disease 6 | 414
Pancreatic Neoplasms 6 | 85
Parkinson's disease 6 | 392
Poor school performance 6 | 645
Small cell carcinoma of lung 6 | 45
Small head 6 | 374
Stomach Neoplasms 6 | 300
Toxic encephalopathy 6 | 141
Acquired scoliosis 5 | 281
Broad flat nasal bridge 5 | 236
Cognitive delay 5 | 608
Curvature of spine 5 | 282
Endometrial cancer 5 | 311
Endometriosis 5 | 540
Feeding difficulties in infancy 5 | 175
Hypertension 5 | 396
Hypoplastic mandible condyle 5 | 275
Major Depressive Disorder 5 | 301
Mental and motor retardation 5 | 608
Nasal bridge wide 5 | 236
Strabismus 5 | 270
Vascular disease 5 | 319
medulloblastoma 5 | 720
nasopharyngeal carcinoma 5 | 1,058
ulcerative colitis 5 | 1,819

Tissue

Blood and immune system 71 | 16,909
Digestive Tract 71 | 17,369
Endocrine System 71 | 18,159
Female tissues 71 | 17,400
Liver and Pancreas 71 | 16,750
Male tissues 71 | 17,142
Nervous System 71 | 16,725
Skin and soft tissues 71 | 17,230
Urinary Tract 71 | 16,678
Respiratory system 70 | 16,393
Cardiovascular System 68 | 15,192

Target Family

Non-IDG 30 | 12,091
Epigenetic 17 | 242
Enzyme 10 | 4,145
Kinase 9 | 634
Transcription Factor 6 | 1,400

GO Function

p53 binding 72 | 72
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 26 DUSP26 Tbio Enzyme -2.81752 661.7 128
Huntingtin HTT Tchem Non-IDG -3.36282 2294.8 599
Zinc finger protein 346 ZNF346 Tbio Non-IDG -2.28393 188.7 213
Telomerase protein component 1 TEP1 Tbio Enzyme -1.74492 50.6 71
Apoptosis-stimulating of p53 protein 2 TP53BP2 Tbio Non-IDG -1.85307 72.5 189
Zinc finger protein 385A ZNF385A Tbio Non-IDG -0.03141 1.24 99
Homeobox protein MSX-1 MSX1 Tbio Transcription Factor -2.59245 390.1 298
Protein BANP BANP Tbio Non-IDG -1.67812 53.3 92
Histone-lysine N-methyltransferase SETD7 SETD7 Tchem Epigenetic -2.13644 139.8 343
Zinc finger matrin-type protein 1 ZMAT1 Tdark Non-IDG 0.30 0.83 45