Development Level

Tbio 6 | 11,445
Tchem 2 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

abnormal pupil morphology 1 | 2
decreased leukocyte cell numbe... 1 | 73
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased leukocyte cell numbe... 1 | 47
limb grasping 1 | 41

Disease

Carcinoma 7 | 11,493
osteosarcoma 5 | 7,950
ovarian cancer 4 | 8,520
glioblastoma 3 | 5,792
pancreatic cancer 3 | 2,398
psoriasis 3 | 6,694
Anhidrosis 2 | 23
Autosomal recessive congenital ichthyosis 2 | 11
Autosomal recessive predisposition 2 | 1,442
Congenital Nonbullous Ichthyosiform Erythroderma 2 | 16
Congenital ichthyosiform erythroderma 2 | 28
Congenital ichthyosis 2 | 3
Congenital non-bullous ichthyosiform erythroderma 2 | 7
Dull intelligence 2 | 645
ICHTHYOSIFORM ERYTHRODERMA, CONGENITAL, NONBULLOUS, 1 2 | 3
Ichthyosiform erythroderma, Brocq congenital, nonbullous form 2 | 2
Ichthyosis 2 | 56
Ichthyosis, Congenital, Autosomal Recessive 2 2 | 3
Ichthyosis, Lamellar 2 | 4
Intellectual disability 2 | 1,016
Low intelligence 2 | 645
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Poor school performance 2 | 645
Self-Healing Collodion Baby 2 | 3
ependymoma 2 | 4,679
primary pancreatic ductal adenocarcinoma 2 | 1,109
AUTISM, SUSCEPTIBILITY TO, X-LINKED 6 1 | 2
Abnormal helices 1 | 11
Abnormality of retinal pigmentation 1 | 111
Abnormality of the retinal vasculature 1 | 59
Absence of eyebrows 1 | 31
Actinic keratosis 1 | 21
Alopecia 1 | 115
Aplasia/Hypoplasia of the eyebrow 1 | 31
Atypical scarring of skin 1 | 62
Blindness 1 | 88
Cerebellar vermis aplasia or hypoplasia 1 | 12
Cerebellar vermis aplasia/ hypoplasia 1 | 12
Conductive hearing loss 1 | 123
Cone dystrophy 1 | 71
Congenital anomaly of testis 1 | 52
Congenital deafness 1 | 185
Corneal erosion 1 | 16
Deafness 1 | 198
Decreased amplitudes on flash visual electroretinogram 1 | 13
Dermatologic disorders 1 | 93
Difficulties with night vision 1 | 87
Dry skin 1 | 75
Ectropion 1 | 38
Enhanced S-cone syndrome 1 | 17
Everted lower lip vermilion 1 | 54
Exfoliative dermatitis 1 | 24
Eye poking 1 | 2
Fundus atrophy 1 | 2
Fundus dystrophy 1 | 83
Hair shaft abnormalities 1 | 30
Hearing Loss, Partial 1 | 185
Hemiplegia and hemiparesis 1 | 38
Hyperinsulinism 1 | 133
Hyperkeratosis 1 | 50
Hypohidrosis 1 | 34
Hypotrichosis 1 | 47
Ichthyoses 1 | 41
Keratitis 1 | 62
Keratoconus 1 | 113
Lack of skin elasticity 1 | 10
Leber congenital amaurosis 1 | 69
Malformations of Cortical Development, Group II 1 | 31
Nail Diseases 1 | 24
Nail abnormality 1 | 22
Night Blindness 1 | 101
Night blindness, progressive 1 | 51
Opitz-GBBB syndrome 1 | 18
Optic disc abnormalities 1 | 12
Palmoplantar keratosis 1 | 74
Paralysed 1 | 42
Peripheral Nervous System Diseases 1 | 52
Peripheral Neuropathy 1 | 134
Photodysphoria 1 | 121
Photophobia 1 | 121
Protruding lower lip 1 | 54
Pruritus 1 | 58
Reduced visual acuity 1 | 63
Renal clear cell carcinoma 1 | 6
Retinal pigment epithelial abnormality 1 | 111
Sensorineural Hearing Loss (disorder) 1 | 284
Severe early childhood onset retinal dystrophy 1 | 4
Severe visual impairment 1 | 16
Skin Diseases 1 | 71
Sparse or absent eyebrows 1 | 31
Sparse/absent eyebrows 1 | 31
Stretched skin 1 | 10
Tinea corporis 1 | 25
X-linked cerebral adrenoleukodystrophy 1 | 116
Xerosis 1 | 75
facioscapulohumeral dystrophy 1 | 288
hair abnormalities (non-specific) 1 | 30
hearing impairment 1 | 199
inflammatory breast cancer 1 | 286

Tissue

Blood and immune system 9 | 16,909
Digestive Tract 9 | 17,369
Endocrine System 9 | 18,159
Female tissues 9 | 17,400
Male tissues 9 | 17,142
Nervous System 9 | 16,725
Skin and soft tissues 9 | 17,230
Liver and Pancreas 8 | 16,750
Urinary Tract 7 | 16,678
Cardiovascular System 6 | 15,192
Respiratory system 6 | 16,393

Target Family

Enzyme 9 | 4,145

GO Function

oxidoreductase activity, actin... 9 | 9
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beta,beta-carotene 9',10'-oxygenase BCO2 Tbio Enzyme -1.64030 46.1 93
Arachidonate 12-lipoxygenase, 12R-type ALOX12B Tbio Enzyme -1.33994 24.1 71
Arachidonate 12-lipoxygenase, 12S-type ALOX12 Tchem Enzyme -2.35458 223.8 137
Hydroperoxide isomerase ALOXE3 ALOXE3 Tbio Enzyme -1.51120 32.2 118
Trimethyllysine dioxygenase, mitochondrial TMLHE Tbio Enzyme -1.54464 30.5 132
Prolyl 4-hydroxylase subunit alpha-2 P4HA2 Tbio Enzyme -1.04006 10.9 76
Prolyl 4-hydroxylase subunit alpha-1 P4HA1 Tchem Enzyme -1.30977 17.5 172
Prolyl 4-hydroxylase subunit alpha-3 P4HA3 Tdark Enzyme -0.48463 2.86 89
Retinoid isomerohydrolase RPE65 Tbio Enzyme -2.63508 438.4 141