Development Level

Tbio 43 | 10,625
Tdark 31 | 7,003
Tchem 14 | 1,890
Tclin 3 | 602

IMPC Phenotype

preweaning lethality, complete... 7 | 633
abnormal behavior 2 | 226
abnormal coat-hair pigmentatio... 2 | 54
abnormal embryo size 2 | 112
abnormal retinal blood vessel ... 2 | 18
abnormal testis morphology 2 | 30
decreased bone mineral content 2 | 157
decreased circulating calcium ... 2 | 33
decreased lean body mass 2 | 195
hypoactivity 2 | 89
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 93
increased total body fat amoun... 2 | 57
small kidney 2 | 10
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal coat appearance 1 | 25
abnormal cranium morphology 1 | 32
abnormal epididymis morphology 1 | 31
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal gait 1 | 51
abnormal iris morphology 1 | 12
abnormal jejunum morphology 1 | 1
abnormal locomotor activation 1 | 26
abnormal lumbar vertebrae morp... 1 | 6
abnormal lung morphology 1 | 15
abnormal placement of pupils 1 | 4
abnormal respiratory quotient 1 | 9
abnormal response to new envir... 1 | 8
abnormal retina morphology 1 | 100
abnormal retinal vasculature m... 1 | 15
abnormal seminal vesicle morph... 1 | 47
abnormal skin appearance 1 | 8
abnormal sleep behavior 1 | 63
abnormal snout morphology 1 | 18
abnormal stomach morphology 1 | 4
absent vibrissae 1 | 14
anophthalmia 1 | 20
cardiovascular system phenotyp... 1 | 35
cataract 1 | 26
craniofacial phenotype 1 | 9
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating alkaline... 1 | 41
decreased circulating choleste... 1 | 85
decreased circulating serum al... 1 | 79
decreased circulating total pr... 1 | 41
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased heart rate variabili... 1 | 11
decreased red blood cell distr... 1 | 11
decreased threshold for audito... 1 | 32
decreased total body fat amoun... 1 | 186
decreased vertical activity 1 | 22
embryonic lethality prior to o... 1 | 148
enlarged heart 1 | 111
enlarged lymph nodes 1 | 27
hydrops fetalis 1 | 22
hyperactivity 1 | 108
improved glucose tolerance 1 | 56
increased B-1a cell number 1 | 2
increased bone mineral density 1 | 52
increased circulating amylase ... 1 | 13
increased circulating chloride... 1 | 43
increased circulating choleste... 1 | 53
increased circulating fructosa... 1 | 11
increased circulating iron lev... 1 | 25
increased circulating magnesiu... 1 | 10
increased circulating potassiu... 1 | 31
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased erythrocyte cell num... 1 | 26
increased fasted circulating g... 1 | 68
increased heart rate 1 | 17
increased heart weight 1 | 37
increased hematocrit 1 | 36
increased lean body mass 1 | 107
increased rib number 1 | 41
increased startle reflex 1 | 38
male infertility 1 | 62
microcephaly 1 | 3
microphthalmia 1 | 15
narrow eye opening 1 | 15
polycystic kidney 1 | 9
shortened RR interval 1 | 19
small heart 1 | 8
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 11
small testis 1 | 37
tremors 1 | 34

Disease

ovarian cancer 50 | 8,491
osteosarcoma 43 | 7,933
medulloblastoma, large-cell 40 | 6,234
glioblastoma 31 | 5,572
psoriasis 30 | 6,685
atypical teratoid / rhabdoid tumor 26 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 26 | 3,289
astrocytic glioma 25 | 2,241
pancreatic ductal adenocarcinoma liver metastasis 25 | 1,795
ependymoma 21 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,956
lung cancer 21 | 4,473
oligodendroglioma 21 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,988
Cancer 18 | 2,346
pediatric high grade glioma 18 | 2,712
Pick disease 17 | 1,893
pancreatic cancer 17 | 2,300
primitive neuroectodermal tumor 17 | 3,031
malignant mesothelioma 16 | 3,163
medulloblastoma 16 | 1,524
tuberculosis 16 | 1,563
invasive ductal carcinoma 15 | 2,950
lung adenocarcinoma 15 | 2,714
Breast cancer 14 | 3,098
non-small cell lung cancer 14 | 2,798
pilocytic astrocytoma 14 | 3,086
adrenocortical carcinoma 13 | 1,427
diabetes mellitus 13 | 1,663
ductal carcinoma in situ 13 | 1,745
group 4 medulloblastoma 13 | 1,875
lung carcinoma 13 | 2,844
subependymal giant cell astrocytoma 13 | 2,287
adult high grade glioma 12 | 2,148
cystic fibrosis 12 | 1,670
interstitial cystitis 12 | 2,299
posterior fossa group A ependymoma 11 | 1,511
Prostatic Neoplasms 10 | 471
group 3 medulloblastoma 10 | 2,254
Multiple myeloma 9 | 1,327
primary pancreatic ductal adenocarcinoma 9 | 1,271
Liver disease 8 | 219
active Crohn's disease 8 | 918
acute quadriplegic myopathy 8 | 1,157
pituitary cancer 8 | 1,972
ulcerative colitis 8 | 2,087
Alzheimer's disease 7 | 644
Atopic dermatitis 7 | 944
Liver carcinoma 7 | 217
posterior fossa group B ependymoma 7 | 1,530
progressive supranuclear palsy 7 | 674
Obesity 6 | 616
aldosterone-producing adenoma 6 | 664
astrocytoma 6 | 1,493
breast carcinoma 6 | 1,614
colon cancer 6 | 1,475
esophageal adenocarcinoma 6 | 737
gastric carcinoma 6 | 832
non primary Sjogren syndrome sicca 6 | 840
spina bifida 6 | 1,064
Epilepsy 5 | 346
Waldenstrons macroglobulinemia 5 | 764
atypical teratoid/rhabdoid tumor 5 | 1,095
Adverse reaction to drug 4 | 54
Hypertension 4 | 293
Mammary Neoplasms 4 | 410
Parkinson's disease 4 | 364
Schizophrenia 4 | 503
acute myeloid leukemia 4 | 785
cutaneous lupus erythematosus 4 | 1,056
non-small cell lung carcinoma 4 | 413
sonic hedgehog group medulloblastoma 4 | 1,482
Acute kidney injury 3 | 65
Carcinoma 3 | 2,147
Cardiovascular system disease 3 | 194
Drug-Induced Liver Injury 3 | 118
Intellectual disability 3 | 573
Kidney disease 3 | 397
Lipid metabolism disorder 3 | 102
Liver neoplasms 3 | 108
Lung Neoplasms 3 | 171
Major Depressive Disorder 3 | 106
Micronuclei, Chromosome-Defective 3 | 20
Neurodegenerative disease 3 | 383
Parkinson Disease 3 | 105
Rheumatoid Arthritis 3 | 1,170
Squamous cell carcinoma of esophagus 3 | 82
Stomach Neoplasms 3 | 282
active ulcerative colitis 3 | 477
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
gastric cancer 3 | 436
juvenile dermatomyositis 3 | 1,189
nasopharyngeal carcinoma 3 | 1,056
non diabetic and post-ischemic heart failure 3 | 200
pancreatic carcinoma 3 | 567
Down syndrome 2 | 548
Polycystic Ovary Syndrome 2 | 334
Spontaneous abortion 2 | 108
Vascular disease 2 | 281
fibroadenoma 2 | 557

Tissue

Blood and immune system 89 | 17,994
Cardiovascular System 89 | 17,957
Digestive Tract 89 | 18,472
Endocrine System 89 | 18,511
Female tissues 89 | 18,646
Liver and Pancreas 89 | 18,135
Male tissues 89 | 17,968
Nervous System 89 | 18,560
Urinary Tract 89 | 18,443
Respiratory system 88 | 17,483
Skin and soft tissues 87 | 18,114

Target Family

Enzyme 61 | 4,146
Non-IDG 29 | 11,969
Epigenetic 1 | 242

GO Function

oxidoreductase activity 91 | 91
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine-threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Glucose-fructose oxidoreductase domain-containing protein 1 GFOD1 Tdark Enzyme 0.25 0.86 22
Methylmalonic aciduria and homocystinuria type C protein MMACHC Tbio Non-IDG -1.77493 67.0 130
Cytochrome P450 1A1 CYP1A1 Tchem Non-IDG -3.53853 3553.5 340
WW domain-containing oxidoreductase WWOX Tbio Enzyme -3.56179 2916.0 232
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.05 0.56 23
Lysine-specific demethylase hairless HR Tbio Enzyme -1.09980 60.2 86
Glucose-fructose oxidoreductase domain-containing protein 2 GFOD2 Tdark Enzyme 0.24 0.75 114
Uncharacterized protein C1orf43 C1orf43 Tdark Non-IDG -0.62707 4.22 50
Selenoprotein N SELENON Tbio Non-IDG -1.93517 194.0 81
ERO1-like protein beta ERO1B Tbio Non-IDG -0.90916 9.49 83