Development Level

Tbio 41 | 11,445
Tchem 12 | 1,598
Tclin 5 | 613
Tdark 3 | 6,588

IMPC Phenotype

preweaning lethality, complete... 5 | 979
decreased erythrocyte cell num... 2 | 62
increased mean corpuscular hem... 2 | 36
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal snout morphology 1 | 23
cataract 1 | 92
decreased body length 1 | 101
decreased circulating aspartat... 1 | 34
decreased circulating lactate ... 1 | 3
decreased mean corpuscular vol... 1 | 79
increased blood urea nitrogen ... 1 | 48
increased circulating sodium l... 1 | 71
increased grip strength 1 | 41
increased mean platelet volume 1 | 45
increased startle reflex 1 | 112
male infertility 1 | 123
preweaning lethality, incomple... 1 | 499
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

Carcinoma 35 | 11,493
osteosarcoma 27 | 7,950
ovarian cancer 27 | 8,520
psoriasis 23 | 6,694
group 3 medulloblastoma 18 | 4,104
lung cancer 18 | 4,740
glioblastoma 16 | 5,792
medulloblastoma, large-cell 16 | 6,241
Breast cancer 15 | 3,578
Cancer 14 | 2,499
atypical teratoid / rhabdoid tumor 14 | 5,112
invasive ductal carcinoma 13 | 2,951
non-small cell lung cancer 13 | 2,890
primitive neuroectodermal tumor 12 | 3,035
Autosomal recessive predisposition 11 | 1,442
Astrocytoma, Pilocytic 10 | 3,081
ependymoma 10 | 4,679
lung adenocarcinoma 10 | 2,716
malignant mesothelioma 10 | 3,232
pancreatic cancer 10 | 2,398
adult high grade glioma 9 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
lung carcinoma 8 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
tuberculosis 8 | 2,010
Waldenstrons macroglobulinemia 7 | 765
diabetes mellitus 7 | 1,728
ductal carcinoma in situ 7 | 1,745
interstitial cystitis 7 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
Liver Cirrhosis, Experimental 6 | 769
Multiple myeloma 6 | 1,332
Pick disease 6 | 1,894
adrenocortical carcinoma 6 | 1,428
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
pituitary cancer 6 | 1,972
Kidney cancer 5 | 2,613
Obesity 5 | 678
Stomach Neoplasms 5 | 300
colon cancer 5 | 1,478
juvenile dermatomyositis 5 | 1,187
nasopharyngeal carcinoma 5 | 1,058
pancreatic carcinoma 5 | 562
spina bifida 5 | 1,074
ulcerative colitis 5 | 1,819
Acute myeloid leukemia, disease 4 | 30
Adenocarcinoma of pancreas 4 | 14
Anemia 4 | 365
Atopic dermatitis 4 | 952
Epilepsy 4 | 792
Feeding difficulties 4 | 127
Metastatic Breast Carcinoma 4 | 21
Motor delay 4 | 147
No development of motor milestones 4 | 147
astrocytoma 4 | 1,146
breast carcinoma 4 | 1,638
cystic fibrosis 4 | 1,696
dermatomyositis 4 | 966
hepatocellular carcinoma 4 | 547
subependymal giant cell astrocytoma 4 | 2,287
Amyotrophic lateral sclerosis 3 | 451
Atherosclerosis 3 | 291
Bipolar Disorder 3 | 666
Carcinoma, Squamous Cell 3 | 110
Cognitive delay 3 | 608
Colorectal Neoplasms 3 | 243
Coronary artery disease 3 | 268
Dull intelligence 3 | 645
Endometriosis 3 | 540
Failure to gain weight 3 | 365
Global developmental delay 3 | 608
Gout 3 | 106
Hypoplasia of corpus callosum 3 | 90
Hypoplastic mandible condyle 3 | 275
Intellectual disability 3 | 1,016
Kidney disease 3 | 430
Low intelligence 3 | 645
Malignant tumor of ovary 3 | 25
Mandibular hypoplasia 3 | 275
Mental Retardation 3 | 645
Mental and motor retardation 3 | 608
Mental deficiency 3 | 645
Micrognathism 3 | 275
Muscle hypotonia 3 | 571
Neurodegenerative disease 3 | 414
Pediatric failure to thrive 3 | 365
Poor school performance 3 | 645
Prostatic Neoplasms 3 | 495
Schizophrenia 3 | 1,160
Small head 3 | 374
Squamous cell carcinoma 3 | 129
active Crohn's disease 3 | 922
acute myeloid leukemia 3 | 783
acute quadriplegic myopathy 3 | 1,158
cutaneous lupus erythematosus 3 | 1,057
non-small cell lung carcinoma 3 | 317
oligodendroglioma 3 | 2,850
posterior fossa group A ependymoma 3 | 468
posterior fossa group B ependymoma 3 | 416
tuberculosis and treatment for 6 months 3 | 409

Tissue

Digestive Tract 59 | 17,369
Endocrine System 59 | 18,159
Liver and Pancreas 59 | 16,750
Nervous System 59 | 16,725
Skin and soft tissues 59 | 17,230
Urinary Tract 59 | 16,678
Cardiovascular System 58 | 15,192
Female tissues 58 | 17,400
Male tissues 58 | 17,142
Respiratory system 58 | 16,393
Blood and immune system 57 | 16,909

Target Family

Enzyme 33 | 4,145
Non-IDG 20 | 12,091
Transporter 6 | 473
Epigenetic 1 | 242
GPCR 1 | 408

GO Function

nucleotide binding 61 | 61
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Heat shock protein HSP 90-alpha HSP90AA1 Tchem Non-IDG -3.31859 4681.5 1057
5'-nucleotidase NT5E Tchem Enzyme -2.88310 784.5 835
Thymidylate synthase TYMS Tclin Enzyme -2.93426 732.0 733
Cell division control protein 6 homolog CDC6 Tbio Non-IDG -2.51683 336.8 574
Apoptotic protease-activating factor 1 APAF1 Tbio Enzyme -2.76382 570.9 539
Bis(5'-adenosyl)-triphosphatase FHIT Tchem Enzyme -2.86154 789.6 445
NADPH oxidase 4 NOX4 Tchem Enzyme -2.87113 773.1 393
Hypoxanthine-guanine phosphoribosyltransferase HPRT1 Tchem Enzyme -3.37307 2350.7 381
Leukotriene B4 receptor 1 LTB4R Tchem GPCR -2.74171 557.6 365
Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 Tclin Enzyme -1.98040 94.3 247