Development Level

Tbio 15 | 11,445
Tdark 2 | 6,588
Tchem 1 | 1,598

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal bone mineralization 1 | 38
decreased bone mineral density 1 | 126
decreased leukocyte cell numbe... 1 | 73
embryonic lethality prior to t... 1 | 278
increased monocyte cell number 1 | 63
preweaning lethality, incomple... 1 | 499

Disease

ovarian cancer 14 | 8,520
Carcinoma 13 | 11,493
osteosarcoma 13 | 7,950
atypical teratoid / rhabdoid tumor 10 | 5,112
medulloblastoma, large-cell 10 | 6,241
glioblastoma 9 | 5,792
psoriasis 7 | 6,694
Kidney cancer 5 | 2,613
group 4 medulloblastoma 5 | 1,855
lung adenocarcinoma 5 | 2,716
lung cancer 5 | 4,740
ependymoma 4 | 4,679
group 3 medulloblastoma 4 | 4,104
pediatric high grade glioma 4 | 1,064
primitive neuroectodermal tumor 4 | 3,035
Multiple myeloma 3 | 1,332
astrocytic glioma 3 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
oligodendroglioma 3 | 2,850
pancreatic cancer 3 | 2,398
subependymal giant cell astrocytoma 3 | 2,287
Breast cancer 2 | 3,578
Broad flat nasal bridge 2 | 236
Cancer 2 | 2,499
Cognitive delay 2 | 608
Global developmental delay 2 | 608
Intellectual disability 2 | 1,016
Mental and motor retardation 2 | 608
Muscle hypotonia 2 | 571
Nasal bridge wide 2 | 236
Short stature 2 | 531
Tetralogy of Fallot 2 | 63
Waldenstrons macroglobulinemia 2 | 765
Williams-Beuren syndrome 2 | 50
acute myeloid leukemia 2 | 783
adult high grade glioma 2 | 3,801
aldosterone-producing adenoma 2 | 665
colon cancer 2 | 1,478
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
invasive ductal carcinoma 2 | 2,951
malignant mesothelioma 2 | 3,232
non primary Sjogren syndrome sicca 2 | 891
non-small cell lung cancer 2 | 2,890
Abnormality of pulmonary valve 1 | 23
Abnormality of the pharynx 1 | 19
Acne 1 | 52
Adenocarcinoma 1 | 122
Arachnodactyly 1 | 49
Atrial Septal Defects 1 | 85
Atrial heart septal defect 1 | 18
Burkitt Lymphoma 1 | 20
Bushy eyebrows 1 | 49
Cerebellar hypoplasia and atrophy 1 | 41
Cholangiocarcinoma 1 | 35
Chromosome 17q11.2 deletion syndrome, 1.4Mb 1 | 15
Colorectal Neoplasms 1 | 243
Conductive hearing loss 1 | 123
Congenital heart disease 1 | 93
Congenital hypoplasia of kidney 1 | 32
Convex nasal bridge 1 | 57
Dental abnormalities 1 | 60
Dental caries 1 | 164
Depression, Postpartum 1 | 7
DiGeorge syndrome 1 | 47
Dysseborrheic dermatitis 1 | 13
Endometrial Neoplasms 1 | 55
Full lower lip 1 | 64
Generalized hirsutism 1 | 36
Hemolytic anemia 1 | 77
Hepatoblastoma 1 | 19
Hypocalcemia 1 | 32
Hypoparathyroidism 1 | 41
Hypotrophic malar bone 1 | 129
Immunologic Deficiency Syndromes 1 | 113
Impaired T cell function 1 | 14
Long eyelashes 1 | 37
Lymphoid leukemia 1 | 160
Lymphoma, T-Cell, Cutaneous 1 | 22
Malar flattening 1 | 129
Microsatellite Instability 1 | 12
Nephroblastoma 1 | 51
Neuronal ceroid lipofuscinosis 2 1 | 17
Overfolded helix 1 | 24
Patella aplasia-hypoplasia 1 | 12
Postpartum depression 1 | 8
Prominent lower lip 1 | 64
Prominent nasal bridge 1 | 57
Recurrent respiratory infections 1 | 141
Rotting teeth 1 | 73
Seborrheic dermatitis 1 | 31
Sezary Syndrome 1 | 27
Short distal phalanges 1 | 50
Tooth Abnormalities 1 | 69
Velocardiofacial syndrome 1 | 46
Wilms Tumor 1 | 28
ear infection chronic 1 | 52
hearing impairment 1 | 199
inflammatory breast cancer 1 | 286
interstitial lung disease 1 | 298
ventricular septal defect 1 | 20

Tissue

Blood and immune system 18 | 16,909
Cardiovascular System 18 | 15,192
Digestive Tract 18 | 17,369
Endocrine System 18 | 18,159
Female tissues 18 | 17,400
Liver and Pancreas 18 | 16,750
Male tissues 18 | 17,142
Nervous System 18 | 16,725
Respiratory system 18 | 16,393
Skin and soft tissues 18 | 17,230
Urinary Tract 18 | 16,678

Target Family

Non-IDG 9 | 12,091
Enzyme 6 | 4,145
Epigenetic 1 | 242
TF/Epigenetic 1 | 38
Transcription Factor 1 | 1,400

GO Function

nucleosome binding 18 | 18
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transcription elongation factor SPT6 SUPT6H Tbio Non-IDG -1.80696 66.9 123
Nucleosome assembly protein 1-like 4 NAP1L4 Tbio Non-IDG -0.84469 7.05 50
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
FACT complex subunit SPT16 SUPT16H Tbio Enzyme -1.85453 70.7 324
E3 ubiquitin-protein ligase RNF169 RNF169 Tbio Enzyme -0.16291 2.08 60
Deoxynucleotidyltransferase terminal-interacting protein 1 DNTTIP1 Tbio Enzyme -0.54921 3.92 151
AT-rich interactive domain-containing protein 1A ARID1A Tbio Transcription Factor -2.61778 423.3 132
E3 ubiquitin-protein ligase RNF4 RNF4 Tbio Enzyme -1.86505 77.1 80
Nucleolar complex protein 2 homolog NOC2L Tbio Non-IDG -2.54468 350.1 85
Zinc finger HIT domain-containing protein 1 ZNHIT1 Tdark Non-IDG -0.41378 2.04 99