Development Level

Tchem 26 | 1,598
Tclin 14 | 613
Tbio 11 | 11,445

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 5 | 979
decreased body weight 3 | 161
abnormal seminal vesicle morph... 2 | 114
decreased lymphocyte cell numb... 2 | 83
increased blood urea nitrogen ... 2 | 48
increased monocyte cell number 2 | 63
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal maxilla morphology 1 | 17
abnormal response to tactile s... 1 | 17
abnormal sleep behavior 1 | 70
abnormal spinal cord morpholog... 1 | 9
abnormal testis morphology 1 | 43
abnormal urinary bladder morph... 1 | 11
decreased blood urea nitrogen ... 1 | 51
decreased circulating HDL chol... 1 | 68
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased fasted circulating g... 1 | 65
decreased granulocyte number 1 | 6
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 50
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
increased CD4-positive, alpha ... 1 | 4
increased circulating chloride... 1 | 41
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
small testis 1 | 58
thrombocytopenia 1 | 56
tremors 1 | 39

Disease

Carcinoma 45 | 11,493
osteosarcoma 36 | 7,950
Cancer 31 | 2,499
ovarian cancer 28 | 8,520
psoriasis 21 | 6,694
Blastic phase chronic myeloid leukemia 19 | 58
Chronic Myelocytic Leukemia Accelerated Phase 19 | 59
interstitial cystitis 18 | 2,312
medulloblastoma, large-cell 18 | 6,241
Chronic phase chronic myeloid leukemia 17 | 45
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 17 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 17 | 47
glioblastoma 17 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
lung carcinoma 16 | 2,843
lung cancer 15 | 4,740
Kidney cancer 14 | 2,613
invasive ductal carcinoma 14 | 2,951
non-small cell lung cancer 14 | 2,890
ependymoma 13 | 4,679
pancreatic cancer 12 | 2,398
ulcerative colitis 12 | 1,819
atypical teratoid / rhabdoid tumor 11 | 5,112
group 3 medulloblastoma 11 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
tuberculosis 11 | 2,010
cutaneous lupus erythematosus 10 | 1,057
lung adenocarcinoma 10 | 2,716
malignant mesothelioma 10 | 3,232
oligodendroglioma 10 | 2,850
adult high grade glioma 9 | 3,801
astrocytoma 9 | 1,146
group 4 medulloblastoma 9 | 1,855
primary Sjogren syndrome 9 | 735
Astrocytoma, Pilocytic 8 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
juvenile dermatomyositis 8 | 1,187
Breast cancer 7 | 3,578
Rheumatoid arthritis 7 | 1,191
ductal carcinoma in situ 7 | 1,745
primitive neuroectodermal tumor 7 | 3,035
subependymal giant cell astrocytoma 7 | 2,287
Autosomal recessive predisposition 6 | 1,442
Chronic graft-versus-host disease 6 | 6
Chronic lymphoid leukemia, disease 6 | 13
Liver Cirrhosis, Experimental 6 | 769
Mantle cell lymphoma 6 | 23
Multiple myeloma 6 | 1,332
Waldenström macroglobulinemia 6 | 6
dermatomyositis 6 | 966
diabetes mellitus 6 | 1,728
spina bifida 6 | 1,074
Agammaglobulinemia 5 | 34
Atopic dermatitis 5 | 952
Chronic Lymphocytic Leukemia 5 | 262
Immune system cancer 5 | 140
Immunologic Deficiency Syndromes 5 | 113
Lymphoid leukemia 5 | 160
Pick disease 5 | 1,894
Polycythemia vera 5 | 27
Splenomegaly 5 | 190
Systemic lupus erythematosus 5 | 194
Waldenstrons macroglobulinemia 5 | 765
acute myeloid leukemia 5 | 783
cystic fibrosis 5 | 1,696
Anemia 4 | 365
Arthralgia 4 | 90
Arthritis 4 | 290
Diarrhea 4 | 253
Down syndrome 4 | 499
Failure to gain weight 4 | 365
Hepatomegaly 4 | 285
Obesity 4 | 678
Pediatric failure to thrive 4 | 365
Pneumonia 4 | 174
Renal Cell Carcinoma 4 | 214
Thrombocytopenia 4 | 197
astrocytic glioma 4 | 2,597
pancreatic carcinoma 4 | 562
primary pancreatic ductal adenocarcinoma 4 | 1,109
tuberculosis and treatment for 6 months 4 | 409
Alzheimer's disease 3 | 658
Arthritis, Rheumatoid 3 | 174
Chronic otitis media 3 | 52
Crohn's disease 3 | 321
Fever 3 | 138
Liver cancer 3 | 604
Liver neoplasms 3 | 130
Melanoma 3 | 711
Severe combined immunodeficiency 3 | 51
Status Epilepticus 3 | 98
adrenocortical carcinoma 3 | 1,428
breast carcinoma 3 | 1,638
colon cancer 3 | 1,478
fibroadenoma 3 | 559
gastric cancer 3 | 459
gastric carcinoma 3 | 807
mucosa-associated lymphoid tissue lymphoma 3 | 484
nasopharyngeal carcinoma 3 | 1,058
urothelial carcinoma 3 | 318

Tissue

Blood and immune system 51 | 16,909
Digestive Tract 51 | 17,369
Endocrine System 51 | 18,159
Female tissues 51 | 17,400
Liver and Pancreas 51 | 16,750
Male tissues 51 | 17,142
Respiratory system 51 | 16,393
Skin and soft tissues 51 | 17,230
Urinary Tract 51 | 16,678
Nervous System 49 | 16,725
Cardiovascular System 48 | 15,192

Target Family

Kinase 45 | 634
Non-IDG 5 | 12,091
Epigenetic 1 | 242

GO Function

non-membrane spanning protein ... 51 | 51
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein kinase Fer FER Tchem Kinase -1.86307 55.4 414
Dual specificity tyrosine-phosphorylation-regulated kinase 1A DYRK1A Tchem Kinase -2.68760 506.6 336
Tyrosine-protein kinase BAZ1B BAZ1B Tbio Epigenetic -1.45627 32.0 155
Abelson tyrosine-protein kinase 2 ABL2 Tchem Kinase -1.86293 71.2 358
Tyrosine-protein kinase FRK FRK Tchem Kinase -1.68365 49.2 394
Megakaryocyte-associated tyrosine-protein kinase MATK Tbio Kinase -2.98596 792.3 265
Tyrosine-protein kinase TXK TXK Tchem Kinase -2.28365 191.1 194
GRB2-related adapter protein GRAP Tbio Non-IDG -1.51362 31.8 124
Tyrosine-protein kinase Blk BLK Tchem Kinase -1.88753 81.6 418
Non-receptor tyrosine-protein kinase TNK1 TNK1 Tchem Kinase -0.79047 7.71 293