Development Level

Tchem 8 | 1,598
Tbio 6 | 11,445
Tclin 1 | 613
Tdark 1 | 6,588

IMPC Phenotype

abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal seminal vesicle morph... 1 | 114
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
preweaning lethality, complete... 1 | 979

Disease

Carcinoma 15 | 11,493
atypical teratoid / rhabdoid tumor 8 | 5,112
medulloblastoma, large-cell 8 | 6,241
ovarian cancer 7 | 8,520
Schizophrenia 6 | 1,160
ependymoma 6 | 4,679
glioblastoma 6 | 5,792
group 3 medulloblastoma 6 | 4,104
osteosarcoma 6 | 7,950
psoriasis 6 | 6,694
Epilepsy 5 | 792
adult high grade glioma 5 | 3,801
lung carcinoma 5 | 2,843
oligodendroglioma 5 | 2,850
Glaucoma 4 | 239
active ulcerative colitis 4 | 764
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
lung cancer 4 | 4,740
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
primitive neuroectodermal tumor 4 | 3,035
Alcoholic Intoxication, Chronic 3 | 289
Glycine encephalopathy 3 | 29
Hartnup disease 3 | 13
Iminoglycinuria 3 | 4
Intellectual disability 3 | 1,016
Kidney cancer 3 | 2,613
active Crohn's disease 3 | 922
malignant mesothelioma 3 | 3,232
non-small cell lung cancer 3 | 2,890
pancreatic cancer 3 | 2,398
pituitary cancer 3 | 1,972
Alzheimer's disease 2 | 658
Astrocytoma, Pilocytic 2 | 3,081
Attention deficit hyperactivity disorder 2 | 278
Autosomal recessive predisposition 2 | 1,442
Cerebellar Ataxia 2 | 304
Cystinuria 2 | 18
Dull intelligence 2 | 645
Dystonia 2 | 164
Exotropia 2 | 35
Guanidinoacetate methyltransferase deficiency 2 | 4
HYPERGLYCINURIA (disorder) 2 | 12
Hyperekplexia 2 | 16
Hyperglycinuria 2 | 3
Hypertension 2 | 396
Infantile onset 2 | 238
Low intelligence 2 | 645
Major Depressive Disorder 2 | 301
Melanoma 2 | 711
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Muscle Hypertonia 2 | 88
Pellagra 2 | 26
Pick disease 2 | 1,894
Poor school performance 2 | 645
Seizures 2 | 596
Unipolar Depression 2 | 250
astrocytic glioma 2 | 2,597
astrocytoma 2 | 1,146
colon cancer 2 | 1,478
cutaneous lupus erythematosus 2 | 1,057
cystic fibrosis 2 | 1,696
interstitial cystitis 2 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
nasopharyngeal carcinoma 2 | 1,058
spina bifida 2 | 1,074
Absence Epilepsy 1 | 22
Autism Spectrum Disorders 1 | 75
Barrett's esophagus 1 | 182
Brain Diseases 1 | 24
COPD 1 | 118
Cachexia 1 | 50
Class III malocclusion 1 | 78
Decreased projection of midface 1 | 105
Delayed myelination 1 | 22
Developmental Disabilities 1 | 23
Epileptic encephalopathy 1 | 26
Gaucher disease type 3 1 | 67
Hirschsprung Disease 1 | 31
Hydroxyprolinuria 1 | 7
Hyperactive behavior 1 | 91
Hyperopia 1 | 70
Hypertrophy of lower jaw 1 | 78
Hypotrophic malar bone 1 | 129
Hypotrophic midface 1 | 105
Increased size of mandible 1 | 78
Intestinal Obstruction 1 | 31
Malar flattening 1 | 129
Mandibular hyperplasia 1 | 78
Megacolon 1 | 29
Mental deterioration 1 | 32
Midface retrusion 1 | 105
Small midface 1 | 105
Stereotyped Behavior 1 | 37
Stereotypic Movement Disorder 1 | 42
Tall stature 1 | 34
X- linked recessive 1 | 110
mandibular excess (physical finding) 1 | 78
uncontrolled asthma 1 | 56

Tissue

Endocrine System 15 | 18,159
Male tissues 15 | 17,142
Nervous System 15 | 16,725
Blood and immune system 14 | 16,909
Digestive Tract 14 | 17,369
Skin and soft tissues 14 | 17,230
Urinary Tract 14 | 16,678
Female tissues 13 | 17,400
Liver and Pancreas 12 | 16,750
Respiratory system 12 | 16,393
Cardiovascular System 8 | 15,192

Target Family

Transporter 16 | 473

GO Function

neurotransmitter:sodium sympor... 16 | 16
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

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