Development Level

Tbio 2 | 10,625

IMPC Term

abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
decreased bone mineral content 1 | 157
decreased fasted circulating g... 1 | 49
decreased respiratory quotient 1 | 12
decreased startle reflex 1 | 48
hyperactivity 1 | 108
impaired righting response 1 | 19
increased blood urea nitrogen ... 1 | 44
increased circulating creatini... 1 | 29
increased heart weight 1 | 37
preweaning lethality, complete... 1 | 633

Disease

Substance Withdrawal Syndrome 2 | 55
ACTH-independent macronodular adrenal hyperplasia 1 1 | 4
ACTH-secreting pituitary adenoma 1 | 8
Acrodysostosis 1 | 9
Acromegaly 1 | 40
Adenoma 1 | 165
Beckwith-Wiedemann syndrome 1 | 46
Bone cancer 1 | 10
Brachydactyly 1 | 52
Cancer 1 | 2,346
Carcinoma 1 | 2,147
Carney complex 1 | 23
Cholera 1 | 33
Cushing syndrome due to macronodular adrenal hyperplasia 1 | 5
Cushing's syndrome 1 | 47
Early infantile epileptic encephalopathy with suppression bursts 1 | 18
Epilepsy 1 | 346
Epileptic encephalopathy, early infantile, 17 1 | 1
Fibrodysplasia ossificans progressiva 1 | 17
Fibrous dysplasia 1 | 15
GNAS hyperfunction 1 | 4
Hyperphosphatemia 1 | 32
Hyperthyroidism 1 | 50
Hypoparathyroidism 1 | 29
Hypothyroidism 1 | 89
Kidney cancer 1 | 121
Kidney disease 1 | 397
McCune Albright syndrome 1 | 19
McCune-Albright syndrome 1 | 4
Monostotic fibrous dysplasia 1 | 4
Multiple Endocrine Neoplasia Type 1 1 | 30
Obesity 1 | 616
Ossifying fibroma 1 | 13
Pituitary adenoma 1 | 35
Pituitary adenoma, growth hormone-secreting, 1 1 | 5
Polycystic Ovary Syndrome 1 | 335
Primary pigmented nodular adrenocortical disease 1 | 13
Progressive osseous heteroplasia 1 | 4
Pseudohypoparathyroidism 1 | 17
Pseudohypoparathyroidism 1B 1 | 5
Pseudohypoparathyroidism 1C 1 | 2
Pseudohypoparathyroidism type 1C 1 | 4
Pseudohypoparathyroidism, Type 1A 1 | 4
Pseudohypoparathyroidism, Type 1B 1 | 5
Pseudopseudohypoparathyroidism 1 | 6
adrenal gland cancer 1 | 8
adult high grade glioma 1 | 2,148
astrocytoma 1 | 1,493
atypical teratoid / rhabdoid tumor 1 | 4,369
colon cancer 1 | 1,475
facioscapulohumeral dystrophy 1 | 286
glioblastoma 1 | 5,572
lung carcinoma 1 | 2,844
medulloblastoma, large-cell 1 | 6,234
oligodendroglioma 1 | 2,849
osteosarcoma 1 | 7,933
ovarian cancer 1 | 8,492
pancreatic cancer 1 | 2,300
pilocytic astrocytoma 1 | 3,086
pituitary cancer 1 | 1,972
posterior fossa group A ependymoma 1 | 1,511
primitive neuroectodermal tumor 1 | 3,031
psoriasis 1 | 6,685
sonic hedgehog group medulloblastoma 1 | 1,482
subependymal giant cell astrocytoma 1 | 2,287

Tissue

Blood and immune system 2 | 17,995
Cardiovascular System 2 | 17,958
Digestive Tract 2 | 18,473
Endocrine System 2 | 18,512
Female tissues 2 | 18,647
Liver and Pancreas 2 | 18,136
Male tissues 2 | 17,969
Nervous System 2 | 18,561
Respiratory system 2 | 17,484
Urinary Tract 2 | 18,444
Skin and soft tissues 1 | 18,115

Target Family

Non-IDG 2 | 11,969

GO Function

mu-type opioid receptor bindin... 2 | 2
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

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