Development Level

Tbio 4 | 11,651

IMPC Phenotype

abnormal behavior 1 | 298
abnormal bone structure 1 | 187
decreased bone mineral content 1 | 151
decreased circulating iron lev... 1 | 32
decreased fasted circulating g... 1 | 65
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
hyperactivity 1 | 148
impaired righting response 1 | 26
increased circulating creatini... 1 | 38
increased circulating triglyce... 1 | 42
increased heart weight 1 | 62
increased startle reflex 1 | 112
preweaning lethality, complete... 1 | 979

Disease

Carcinoma 4 | 11,493
ovarian cancer 4 | 8,520
Astrocytoma, Pilocytic 3 | 3,081
adult high grade glioma 3 | 3,801
astrocytic glioma 3 | 2,597
atypical teratoid / rhabdoid tumor 3 | 5,112
ependymoma 3 | 4,679
glioblastoma 3 | 5,792
osteosarcoma 3 | 7,950
psoriasis 3 | 6,694
subependymal giant cell astrocytoma 3 | 2,287
Brachydactyly 2 | 156
Breast cancer 2 | 3,578
Cancer 2 | 2,499
Cognitive delay 2 | 608
Epilepsy 2 | 792
Global developmental delay 2 | 608
Kidney cancer 2 | 2,613
Liver Cirrhosis, Experimental 2 | 769
Mental and motor retardation 2 | 608
Substance Withdrawal Syndrome 2 | 55
colon cancer 2 | 1,478
lung cancer 2 | 4,740
lung carcinoma 2 | 2,843
medulloblastoma, large-cell 2 | 6,241
oligodendroglioma 2 | 2,850
pancreatic cancer 2 | 2,398
pituitary cancer 2 | 1,972
primary pancreatic ductal adenocarcinoma 2 | 1,109
primitive neuroectodermal tumor 2 | 3,035
tuberculosis 2 | 2,010
ACTH-secreting pituitary adenoma 1 | 9
Absent/hypoplastic paranasal sinuses 1 | 5
Accessory carpal bone 1 | 2
Acrodysostosis 1 | 12
Anterior concavity of thoracic vertebrae 1 | 1
Anteriorly placed odontoid process 1 | 1
Broad distal phalanx (thumb) 1 | 3
Broad phalanges of the hand 1 | 2
Camptodactyly of toe 1 | 4
Capitate-hamate fusion 1 | 5
Cardiac valvular dysplasia, X-linked 1 | 1
Congenital Short Bowel Syndrome 1 | 2
Cor pulmonale 1 | 6
Craniofacial hyperostosis 1 | 11
Cushing syndrome due to macronodular adrenal hyperplasia 1 | 5
DOID:3297 1 | 4
Decreased pneumatization of frontal sinus 1 | 6
Delayed closure of the soft spot on the skull 1 | 11
Delayed coalescence of calcaneal ossification centers 1 | 2
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 17 1 | 1
Enlargement of craniofacial bones 1 | 11
Fibular aplasia 1 | 6
Flexion contracture - wrist 1 | 6
Frontometaphyseal dysplasia 1 | 2
Fused cervical vertebrae 1 | 5
Hirsute forehead 1 | 1
Hyperplasia of forehead 1 | 3
Hypertrophy of craniofacial bones 1 | 11
Hypertrophy of forehead 1 | 3
Hypotrophic frontal sinus 1 | 6
Increased density of long bone diaphyses 1 | 1
Increased mean platelet volume 1 | 6
Irregular metacarpals 1 | 2
Large forehead 1 | 3
Late closure of anterior fontanel 1 | 11
Localized Skin Lesion 1 | 1
Long foot 1 | 8
Long metacarpals 1 | 2
Long neck 1 | 3
Mccune-Albright Syndrome 1 | 4
Melnick-Needles Syndrome 1 | 1
Missing all teeth 1 | 3
Monostotic fibrous dysplasia 1 | 4
Multiple buried teeth 1 | 2
Multiple impacted teeth 1 | 2
Noisy respiration 1 | 5
Opitz-Kaveggia Syndrome 1 | 3
Oto-Palato-digital syndrome type 1 1 | 2
Partial fusion of carpals 1 | 1
Partial fusion of tarsals 1 | 1
Pituitary Adenoma, Growth Hormone-Secreting, 1 1 | 5
Posterior vertebral hypoplasia 1 | 3
Progressive osseous heteroplasia 1 | 4
Pseudohypoparathyroidism type 1C 1 | 4
Pseudohypoparathyroidism, Type 1A 1 | 4
Pseudohypoparathyroidism, Type 1B 1 | 5
Pseudopseudohypoparathyroidism 1 | 6
Radial bowing 1 | 13
Second finger clinodactyly 1 | 5
Senile entropion 1 | 1
Short distal phalanx of hallux 1 | 2
Short hallux 1 | 16
Stenosis of ureter 1 | 2
Stridor 1 | 5
Synostosis of carpal bones 1 | 9
Thick craniofacial bones 1 | 11
Thick skull base 1 | 2
Tricuspid Valve Prolapse 1 | 3
VALVULAR ABNORMALITY 1 | 12

Tissue

Blood and immune system 3 | 16,909
Cardiovascular System 3 | 15,192
Digestive Tract 3 | 17,369
Endocrine System 3 | 18,159
Female tissues 3 | 17,400
Liver and Pancreas 3 | 16,750
Male tissues 3 | 17,142
Nervous System 3 | 16,725
Respiratory system 3 | 16,393
Skin and soft tissues 3 | 17,230
Urinary Tract 3 | 16,678

Target Family

Non-IDG 4 | 12,091

GO Function

mu-type opioid receptor bindin... 4 | 4
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein wntless homolog WLS Tbio Non-IDG -2.50699 316.3 71
Filamin-A FLNA Tbio Non-IDG -3.36866 2312.4 441
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas GNAS Tbio Non-IDG -2.63356 1389.7 509
Guanine nucleotide-binding protein G(o) subunit alpha GNAO1 Tbio Non-IDG -2.24331 158.7 195