Development Level

Tbio 38 | 11,445
Tdark 10 | 6,588
Tchem 2 | 1,598

Collection

GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 10 | 979
abnormal embryo size 3 | 220
abnormal sleep behavior 2 | 70
convulsive seizures 2 | 13
cyanosis 2 | 7
decreased caudal vertebrae num... 2 | 53
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased startle reflex 2 | 75
hyperactivity 2 | 148
impaired pupillary reflex 2 | 26
increased or absent threshold ... 2 | 101
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal digit morphology 1 | 10
abnormal forebrain morphology 1 | 10
abnormal ileum morphology 1 | 2
abnormal lung morphology 1 | 26
abnormal motor learning 1 | 3
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal tail morphology 1 | 25
abnormal vocalization 1 | 21
abnormal whole-body plethysmog... 1 | 4
absent startle reflex 1 | 24
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
decreased anxiety-related resp... 1 | 12
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating amylase ... 1 | 28
decreased circulating creatini... 1 | 39
decreased circulating iron lev... 1 | 32
decreased circulating triglyce... 1 | 79
decreased exploration in new e... 1 | 11
decreased grip strength 1 | 116
decreased prepulse inhibition 1 | 82
decreased urine creatinine lev... 1 | 3
edema 1 | 59
embryonic growth retardation 1 | 106
fused cornea and lens 1 | 5
fused phalanges 1 | 1
hemorrhage 1 | 23
increased body length 1 | 32
increased circulating creatini... 1 | 38
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased total body fat amoun... 1 | 134
increased vertical activity 1 | 24
persistence of hyaloid vascula... 1 | 33
polycystic kidney 1 | 15
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
tremors 1 | 39

Disease

Carcinoma 35 | 11,493
ovarian cancer 25 | 8,520
osteosarcoma 22 | 7,950
atypical teratoid / rhabdoid tumor 21 | 5,112
psoriasis 21 | 6,694
ependymoma 19 | 4,679
Kidney cancer 18 | 2,613
glioblastoma 18 | 5,792
Breast cancer 15 | 3,578
adult high grade glioma 15 | 3,801
lung cancer 15 | 4,740
malignant mesothelioma 14 | 3,232
medulloblastoma, large-cell 14 | 6,241
non-small cell lung cancer 14 | 2,890
Astrocytoma, Pilocytic 12 | 3,081
group 3 medulloblastoma 12 | 4,104
primitive neuroectodermal tumor 12 | 3,035
lung carcinoma 11 | 2,843
oligodendroglioma 10 | 2,850
Liver cancer 9 | 604
invasive ductal carcinoma 9 | 2,951
Pick disease 8 | 1,894
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
Autosomal recessive predisposition 7 | 1,442
astrocytic glioma 7 | 2,597
ductal carcinoma in situ 7 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
lung adenocarcinoma 7 | 2,716
Endometrial cancer 6 | 311
Schizophrenia 6 | 1,160
acute quadriplegic myopathy 6 | 1,158
diabetes mellitus 6 | 1,728
nasopharyngeal carcinoma 6 | 1,058
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
pituitary cancer 6 | 1,972
subependymal giant cell astrocytoma 6 | 2,287
Nonsyndromic deafness 5 | 142
Sensorineural hearing loss 5 | 106
adrenocortical carcinoma 5 | 1,428
astrocytoma 5 | 1,146
colon cancer 5 | 1,478
cutaneous lupus erythematosus 5 | 1,057
group 4 medulloblastoma 5 | 1,855
interstitial cystitis 5 | 2,312
progressive supranuclear palsy 5 | 676
spina bifida 5 | 1,074
Atopic dermatitis 4 | 952
Cardiovascular system disease 4 | 246
Neurodegenerative disease 4 | 414
Progressive disorder 4 | 142
chronic rhinosinusitis 4 | 512
pancreatic cancer 4 | 2,398
Babinski Reflex 3 | 100
Breast Neoplasms 3 | 445
Hyperreflexia 3 | 209
Kartagener Syndrome 3 | 38
Male infertility 3 | 206
Melanoma 3 | 711
Monoparesis - leg 3 | 27
Multiple myeloma 3 | 1,332
Neuropathy 3 | 261
Paraplegia 3 | 74
Primary ciliary dyskinesia 3 | 76
Situs Inversus 3 | 65
Skin cancer 3 | 469
Weakness of lower limb 3 | 27
acute myeloid leukemia 3 | 783
dermatomyositis 3 | 966
facioscapulohumeral dystrophy 3 | 288
tuberculosis 3 | 2,010
ulcerative colitis 3 | 1,819
Amyotrophic lateral sclerosis 2 | 451
Cancer 2 | 2,499
Down syndrome 2 | 499
Dysarthria 2 | 192
Endometriosis 2 | 540
Epilepsy 2 | 792
Focal glomerulosclerosis 2 | 37
Glomerulosclerosis, Focal Segmental 2 | 28
Leukemia 2 | 104
Muscle Spasticity 2 | 195
Proteinuria 2 | 144
Slow progression 2 | 89
Spastic Paraplegia 2 | 42
Substance-Related Disorders 2 | 115
breast carcinoma 2 | 1,638
chronic lymphosyte leukemia 2 | 204
cystic fibrosis 2 | 1,696
fibroadenoma 2 | 559
hepatocellular carcinoma 2 | 547
hereditary spastic paraplegia 2 | 318
juvenile dermatomyositis 2 | 1,187
medulloblastoma 2 | 720
muscle degeneration 2 | 139
non diabetic and post-ischemic heart failure 2 | 200
pediatric high grade glioma 2 | 1,064
posterior fossa group A ependymoma 2 | 468
posterior fossa group B ependymoma 2 | 416
tuberculosis and treatment for 6 months 2 | 409

Tissue

Endocrine System 48 | 18,159
Skin and soft tissues 47 | 17,230
Digestive Tract 46 | 17,369
Male tissues 46 | 17,142
Female tissues 45 | 17,400
Respiratory system 45 | 16,393
Blood and immune system 44 | 16,909
Liver and Pancreas 44 | 16,750
Nervous System 44 | 16,725
Urinary Tract 43 | 16,678
Cardiovascular System 42 | 15,192

Target Family

Non-IDG 47 | 12,091
Enzyme 1 | 4,145
GPCR 1 | 408
Kinase 1 | 634

GO Function

motor activity 50 | 50
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Unconventional myosin-XV MYO15A Tbio Non-IDG -1.64094 42.8 15
Kinesin-like protein KIF18B KIF18B Tbio Non-IDG -0.83463 5.23 17
Myosin-IIIb MYO3B Tbio Kinase -0.73450 5.14 127
Dynein intermediate chain 1, axonemal DNAI1 Tbio Non-IDG -1.90654 78.9 160
Unconventional myosin-IXa MYO9A Tdark Non-IDG -0.82985 8.76 21
Myosin-15 MYH15 Tbio Non-IDG -0.95780 9.01 40
Unconventional myosin-X MYO10 Tbio Non-IDG -1.49855 36.4 47
Dynein light chain Tctex-type 3 DYNLT3 Tbio Non-IDG -0.83800 6.25 70
Cytoplasmic dynein 2 heavy chain 1 DYNC2H1 Tbio Non-IDG -1.60757 39.5 23
Kinesin heavy chain isoform 5A KIF5A Tbio Non-IDG -1.69131 48.4 170