Development Level

Tbio 9 | 11,445
Tchem 6 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal cranium morphology 1 | 36
abnormal retina morphology 1 | 71
decreased circulating serum al... 1 | 82
decreased spleen weight 1 | 10
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged kidney 1 | 14
increased circulating alkaline... 1 | 122
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97

Disease

Carcinoma 16 | 11,493
ovarian cancer 8 | 8,520
Cancer 7 | 2,499
osteosarcoma 7 | 7,950
atypical teratoid / rhabdoid tumor 6 | 5,112
Breast cancer 5 | 3,578
Kidney cancer 5 | 2,613
glioblastoma 5 | 5,792
group 3 medulloblastoma 5 | 4,104
lung cancer 5 | 4,740
medulloblastoma, large-cell 5 | 6,241
Pick disease 4 | 1,894
adult high grade glioma 4 | 3,801
astrocytic glioma 4 | 2,597
ductal carcinoma in situ 4 | 1,745
ependymoma 4 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
lung adenocarcinoma 4 | 2,716
malignant mesothelioma 4 | 3,232
non-small cell lung cancer 4 | 2,890
oligodendroglioma 4 | 2,850
psoriasis 4 | 6,694
Arthritis 3 | 290
Astrocytoma, Pilocytic 3 | 3,081
Lung Neoplasms 3 | 232
Schizophrenia 3 | 1,160
invasive ductal carcinoma 3 | 2,951
juvenile dermatomyositis 3 | 1,187
lung carcinoma 3 | 2,843
pancreatic cancer 3 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
primitive neuroectodermal tumor 3 | 3,035
spina bifida 3 | 1,074
subependymal giant cell astrocytoma 3 | 2,287
Acquired flat foot 2 | 72
Acquired immunodeficiency syndrome 2 | 197
Aortic aneurysm 2 | 38
Brain Ischemia 2 | 110
Coronary artery disease 2 | 268
Coughing 2 | 25
Duchenne muscular dystrophy 2 | 601
Fatigue 2 | 182
Flatfoot 2 | 73
Gastrointestinal system disease 2 | 54
Intellectual disability 2 | 1,016
Neoplasm Metastasis 2 | 168
Prostatic Neoplasms 2 | 495
Squamous cell carcinoma 2 | 129
Vascular disease 2 | 319
active ulcerative colitis 2 | 764
acute quadriplegic myopathy 2 | 1,158
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
breast carcinoma 2 | 1,638
cystic fibrosis 2 | 1,696
diabetes mellitus 2 | 1,728
esophageal adenocarcinoma 2 | 737
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
mucosa-associated lymphoid tissue lymphoma 2 | 484
Aarskog syndrome 1 | 12
Abnormality of earlobe 1 | 5
Adrenal Gland Neoplasms 1 | 11
Aggressive systemic mastocytosis 1 | 20
Arterial tortuosity 1 | 5
Blastic phase chronic myeloid leukemia 1 | 58
Bowed and upward slanting eyebrows 1 | 41
Brain Neoplasms 1 | 33
Cervical cancer 1 | 24
Cholestasis, Extrahepatic 1 | 25
Chronic Myelocytic Leukemia Accelerated Phase 1 | 59
Cleft uvula 1 | 27
Clostridium difficile colitis 1 | 12
Conjunctivitis 1 | 53
Conjunctivitis, recurrent 1 | 37
Diabetic Nephropathy 1 | 34
Fractures, Bone 1 | 13
Head and Neck Neoplasms 1 | 26
Hereditary nonpolyposis colorectal carcinoma 1 | 18
Hypertrophy 1 | 17
Infection of bone 1 | 19
Irritation - emotion 1 | 68
Joint laxity 1 | 54
Linear atrophy 1 | 15
Liver Neoplasms, Experimental 1 | 59
Loeys-Dietz syndrome 1 | 23
Lyme disease 1 | 26
Malignant tumor of colon 1 | 19
Mast cell leukemia 1 | 13
Pneumonia, Pneumococcal 1 | 6
Radiation Injuries, Experimental 1 | 11
Saethre-Chotzen syndrome 1 | 7
Sepsis 1 | 24
Sinusitis 1 | 65
Sternal anomalies 1 | 19
Streptococcal pneumonia 1 | 6
Substance Withdrawal Syndrome 1 | 55
Thick, flared eyebrows 1 | 41
Thin hypoplastic alae nasi 1 | 51
Trigeminal Neuralgia 1 | 24
Wiskott-Aldrich syndrome 1 | 30
adult-onset Still's disease 1 | 8

Tissue

Endocrine System 16 | 18,159
Blood and immune system 15 | 16,909
Cardiovascular System 15 | 15,192
Digestive Tract 15 | 17,369
Female tissues 15 | 17,400
Liver and Pancreas 15 | 16,750
Male tissues 15 | 17,142
Nervous System 15 | 16,725
Respiratory system 15 | 16,393
Skin and soft tissues 15 | 17,230
Urinary Tract 15 | 16,678

Target Family

Kinase 6 | 634
Non-IDG 5 | 12,091
Enzyme 4 | 4,145
Transcription Factor 1 | 1,400

GO Function

mitogen-activated protein kina... 16 | 16
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitogen-activated protein kinase kinase kinase kinase 2 MAP4K2 Tchem Kinase -1.60423 35.3 193
SAM and SH3 domain-containing protein 1 SASH1 Tbio Non-IDG -1.50284 36.9 182
Serine/threonine-protein phosphatase with EF-hands 2 PPEF2 Tbio Enzyme -0.26680 1.77 58
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380
Dual specificity mitogen-activated protein kinase kinase 4 MAP2K4 Tchem Kinase -2.43646 236.7 998
Transcription factor E2-alpha TCF3 Tbio Transcription Factor -2.80290 601.6 434
MARVEL domain-containing protein 3 MARVELD3 Tbio Non-IDG -0.76427 6.41 40
Serine/threonine-protein kinase 38 STK38 Tbio Kinase -1.32086 23.2 359
Mitogen-activated protein kinase kinase kinase 11 MAP3K11 Tchem Kinase -1.86198 89.8 205
TNF receptor-associated factor 6 TRAF6 Tbio Non-IDG -2.74221 511.1 403