Development Level

Tbio 7 | 11,445
Tchem 4 | 1,598
Tclin 3 | 613

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

abnormal embryo size 2 | 220
preweaning lethality, complete... 2 | 979
preweaning lethality, incomple... 2 | 499
abnormal facial morphology 1 | 17
abnormal head shape 1 | 10
abnormal lens morphology 1 | 81
abnormal outer ear morphology 1 | 3
abnormal seminal vesicle morph... 1 | 114
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
increased mean corpuscular hem... 1 | 96
increased startle reflex 1 | 112
microphthalmia 1 | 26
prolonged ST segment 1 | 36
thrombocytopenia 1 | 56

Disease

Carcinoma 13 | 11,493
Cancer 7 | 2,499
glioblastoma 7 | 5,792
osteosarcoma 7 | 7,950
ovarian cancer 7 | 8,520
medulloblastoma, large-cell 6 | 6,241
Breast cancer 5 | 3,578
astrocytic glioma 5 | 2,597
ependymoma 5 | 4,679
non-small cell lung cancer 5 | 2,890
oligodendroglioma 5 | 2,850
psoriasis 5 | 6,694
tuberculosis 5 | 2,010
Kidney cancer 4 | 2,613
Lung Neoplasms 4 | 232
adrenocortical carcinoma 4 | 1,428
atypical teratoid / rhabdoid tumor 4 | 5,112
lung cancer 4 | 4,740
malignant mesothelioma 4 | 3,232
Astrocytoma, Pilocytic 3 | 3,081
Breast Neoplasms 3 | 445
Cardiac Arrhythmia 3 | 103
Heart disease 3 | 306
Mammary Neoplasms 3 | 425
Pilocytic astrocytoma 3 | 56
Prostatic Neoplasms 3 | 495
adult high grade glioma 3 | 3,801
diabetes mellitus 3 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
lung adenocarcinoma 3 | 2,716
pediatric high grade glioma 3 | 1,064
ATRIOVENTRICULAR CANAL DEFECT 2 | 17
Abnormality of pulmonary valve 2 | 23
Aortic aneurysm 2 | 38
Bleeding tendency 2 | 37
Blepharoptosis 2 | 231
Blood Coagulation Disorders 2 | 42
Brain Ischemia 2 | 110
Carcinoma of thyroid 2 | 17
Carcinoma, Hepatocellular 2 | 228
Cardiac conduction abnormalities 2 | 78
Cardiomyopathy 2 | 116
Cervical cancer 2 | 24
Coagulation abnormalities 2 | 27
Coarse hair 2 | 31
Conduction disorder of the heart 2 | 79
Decreased fertility 2 | 33
Decreased projection of midface 2 | 105
Downward slant of palpebral fissure 2 | 158
Dry skin 2 | 75
Dysarthria 2 | 192
EKG abnormalities 2 | 78
Electrocardiogram abnormal 2 | 81
Electrocardiogram change 2 | 78
Endocardial Cushion Defects 2 | 17
Exophthalmos 2 | 112
Freckles 2 | 33
Glioma 2 | 74
Hemorrhagic Disorders 2 | 30
High forehead 2 | 102
Hypertrophic Cardiomyopathy 2 | 117
Hypogonadism, Isolated Hypogonadotropic 2 | 71
Hypogonadotropic hypogonadism 2 | 89
Hypotrophic midface 2 | 105
Joint hyperflexibility 2 | 78
Kidney Neoplasm 2 | 29
Kidney Neoplasms 2 | 37
Liver Cirrhosis 2 | 181
Liver carcinoma 2 | 240
Liver cell carcinoma 2 | 15
Liver neoplasms 2 | 130
Long narrow head 2 | 75
Low posterior hairline 2 | 52
Lymphangioma, Cystic 2 | 21
Major Depressive Disorder 2 | 301
Melanocytic nevus 2 | 43
Midface retrusion 2 | 105
Mitral Valve Prolapse Syndrome 2 | 39
Muscle Weakness 2 | 170
Myocardial Infarction 2 | 151
Narrow cranium shape 2 | 75
Narrow head shape 2 | 75
Narrow skull shape 2 | 75
Noncancerous mole 2 | 28
Prominent eyes 2 | 96
Prominent globes 2 | 96
Prominent lower lip 2 | 64
Protruding eyes 2 | 96
Pulmonary Stenosis 2 | 45
Pulmonary artery stenosis 2 | 22
Renal Cell Carcinoma 2 | 214
Rough hair texture 2 | 31
Skin hyperelastic 2 | 32
Small midface 2 | 105
Sprengel deformity 2 | 16
Tall forehead 2 | 102
Triangular face 2 | 58
Turridolichocephaly 2 | 75
Unipolar Depression 2 | 250
Xerosis 2 | 75

Tissue

Blood and immune system 14 | 16,909
Cardiovascular System 14 | 15,192
Digestive Tract 14 | 17,369
Endocrine System 14 | 18,159
Female tissues 14 | 17,400
Liver and Pancreas 14 | 16,750
Male tissues 14 | 17,142
Nervous System 14 | 16,725
Respiratory system 14 | 16,393
Skin and soft tissues 14 | 17,230
Urinary Tract 14 | 16,678

Target Family

Kinase 8 | 634
Enzyme 3 | 4,145
Non-IDG 3 | 12,091

GO Function

mitogen-activated protein kina... 14 | 14
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase TAO2 TAOK2 Tchem Kinase -1.52454 36.1 154
Angiotensin-converting enzyme ACE Tclin Enzyme -4.52754 30363.8 643
Mitogen-activated protein kinase kinase kinase 11 MAP3K11 Tchem Kinase -1.86198 89.8 205
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 PIN1 Tchem Enzyme -2.44422 522.8 528
Beta-arrestin-1 ARRB1 Tbio Non-IDG -2.63877 418.5 490
Tribbles homolog 1 TRIB1 Tbio Kinase -1.74370 59.4 250
Tribbles homolog 3 TRIB3 Tbio Kinase -1.93599 97.7 421
Disks large homolog 1 DLG1 Tbio Non-IDG -2.19822 171.8 185
Tribbles homolog 2 TRIB2 Tbio Kinase -1.49133 35.3 157
Serine/threonine-protein kinase A-Raf ARAF Tchem Kinase -2.46615 277.6 465