Development Level

Tbio 99 | 10,625
Tchem 15 | 1,890
Tdark 8 | 7,003
Tclin 1 | 602

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 11 | 633
embryonic lethality prior to t... 5 | 187
embryonic lethality prior to o... 4 | 148
increased mean corpuscular hem... 4 | 93
abnormal behavior 3 | 226
decreased bone mineral content 3 | 157
decreased lean body mass 3 | 195
hyperactivity 3 | 108
increased lean body mass 3 | 107
abnormal bone structure 2 | 131
abnormal retina morphology 2 | 100
decreased body length 2 | 108
decreased bone mineral density 2 | 126
decreased circulating serum al... 2 | 79
decreased mean corpuscular vol... 2 | 50
decreased total body fat amoun... 2 | 186
increased circulating alkaline... 2 | 119
increased hematocrit 2 | 36
increased mean corpuscular vol... 2 | 91
persistence of hyaloid vascula... 2 | 22
abnormal allantois morphology 1 | 3
abnormal behavioral response t... 1 | 52
abnormal chorioallantoic fusio... 1 | 2
abnormal coat/ hair morphology 1 | 18
abnormal coat/hair pigmentatio... 1 | 54
abnormal cranium morphology 1 | 32
abnormal embryo size 1 | 112
abnormal embryo turning 1 | 15
abnormal eye morphology 1 | 38
abnormal head morphology 1 | 10
abnormal lens morphology 1 | 73
abnormal limb bud morphology 1 | 15
abnormal lung morphology 1 | 15
abnormal nail morphology 1 | 7
abnormal neural tube closure 1 | 37
abnormal neural tube morpholog... 1 | 8
abnormal optic disc morphology 1 | 10
abnormal retinal blood vessel ... 1 | 18
abnormal retinal vasculature m... 1 | 15
abnormal sleep behavior 1 | 63
abnormal tail bud morphology 1 | 6
cardiovascular system phenotyp... 1 | 35
convulsive seizures 1 | 11
decreased CD4-positive, CD25-p... 1 | 24
decreased NK T cell number 1 | 28
decreased anxiety-related resp... 1 | 12
decreased body weight 1 | 174
decreased circulating aspartat... 1 | 27
decreased circulating glucose ... 1 | 121
decreased circulating triglyce... 1 | 83
decreased erythrocyte cell num... 1 | 43
decreased fasted circulating g... 1 | 49
decreased gamma-delta T cell n... 1 | 18
decreased heart rate variabili... 1 | 11
decreased leukocyte cell numbe... 1 | 54
decreased total retina thickne... 1 | 20
embryonic growth retardation 1 | 28
increased bone mineral content 1 | 92
increased circulating aspartat... 1 | 17
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 43
increased circulating thyroxin... 1 | 7
increased erythrocyte cell num... 1 | 26
increased exploration in new e... 1 | 56
increased fasted circulating g... 1 | 68
increased grip strength 1 | 83
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 37
increased mature B cell number 1 | 12
increased or absent threshold ... 1 | 128
increased startle reflex 1 | 38
male infertility 1 | 62
pale yolk sac 1 | 12
pallor 1 | 13
polycystic kidney 1 | 9
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
short tibia 1 | 82
thrombocytosis 1 | 23

Disease

ovarian cancer 69 | 8,484
medulloblastoma, large-cell 63 | 6,234
glioblastoma 59 | 5,572
psoriasis 56 | 6,685
osteosarcoma 55 | 7,933
lung cancer 49 | 4,466
atypical teratoid / rhabdoid tumor 43 | 4,369
primitive neuroectodermal tumor 32 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 29 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 29 | 3,289
Pick disease 27 | 1,893
invasive ductal carcinoma 26 | 2,950
oligodendroglioma 26 | 2,849
Breast cancer 25 | 3,094
group 3 medulloblastoma 25 | 2,254
malignant mesothelioma 25 | 3,162
pediatric high grade glioma 25 | 2,712
pilocytic astrocytoma 25 | 3,086
subependymal giant cell astrocytoma 25 | 2,287
Cancer 22 | 2,346
non-small cell lung cancer 22 | 2,798
adult high grade glioma 21 | 2,148
lung carcinoma 21 | 2,844
colon cancer 20 | 1,475
lung adenocarcinoma 19 | 2,713
Carcinoma 18 | 2,147
ependymoma 18 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,956
Neurodegenerative disease 17 | 383
breast carcinoma 17 | 1,614
pancreatic cancer 17 | 2,300
astrocytic glioma 16 | 2,241
medulloblastoma 16 | 1,524
pituitary cancer 16 | 1,972
Atopic dermatitis 15 | 944
Multiple myeloma 15 | 1,327
adrenocortical carcinoma 15 | 1,427
ulcerative colitis 15 | 2,087
astrocytoma 14 | 1,493
atypical teratoid/rhabdoid tumor 14 | 1,095
posterior fossa group B ependymoma 14 | 1,530
sonic hedgehog group medulloblastoma 14 | 1,482
ductal carcinoma in situ 13 | 1,745
group 4 medulloblastoma 13 | 1,875
tuberculosis 13 | 1,557
Alzheimer's disease 12 | 644
Waldenstrons macroglobulinemia 12 | 765
interstitial cystitis 12 | 2,299
Down syndrome 11 | 548
acute quadriplegic myopathy 11 | 1,157
Endometriosis 10 | 535
Intellectual disability 10 | 573
dermatomyositis 10 | 933
diabetes mellitus 10 | 1,663
nasopharyngeal carcinoma 10 | 1,056
non-small cell lung carcinoma 10 | 413
posterior fossa group A ependymoma 10 | 1,511
cutaneous lupus erythematosus 9 | 1,056
juvenile dermatomyositis 9 | 1,189
progressive supranuclear palsy 9 | 674
spina bifida 9 | 1,064
Amyotrophic Lateral Sclerosis 8 | 431
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
primary pancreatic ductal adenocarcinoma 8 | 1,271
Neuropathy 7 | 210
acute myeloid leukemia 7 | 780
cystic fibrosis 7 | 1,665
gastric carcinoma 7 | 832
hereditary spastic paraplegia 7 | 313
inflammatory breast cancer 7 | 404
tuberculosis and treatment for 6 months 7 | 686
Lissencephaly 6 | 61
Prostatic Neoplasms 6 | 471
Rheumatoid Arthritis 6 | 1,160
Vascular disease 6 | 281
active Crohn's disease 6 | 918
gastric cancer 6 | 430
Charcot-Marie-Tooth disease 5 | 74
Duchenne muscular dystrophy 5 | 602
Epilepsy 5 | 346
IGA Glomerulonephritis 5 | 454
Microcephaly 5 | 149
Multiple Sclerosis 5 | 498
Parkinson's disease 5 | 364
Polycystic Ovary Syndrome 5 | 332
Toxic encephalopathy 5 | 131
chronic rhinosinusitis 5 | 512
cystic fibrosis and chronic rhinosinusitis 5 | 213
fibroadenoma 5 | 557
hepatocellular carcinoma 5 | 532
pancreatic carcinoma 5 | 567
Cerebrovascular disease 4 | 231
Crohn's disease 4 | 304
Peripheral Neuropathy 4 | 303
Schizophrenia 4 | 501
aldosterone-producing adenoma 4 | 664
chronic lymphosyte leukemia 4 | 232
esophageal adenocarcinoma 4 | 737
periodontitis 4 | 269
primary Sjogren syndrome 4 | 789

Tissue

Blood and immune system 120 | 17,995
Female tissues 120 | 18,647
Male tissues 120 | 17,969
Nervous System 120 | 18,561
Cardiovascular System 119 | 17,958
Digestive Tract 119 | 18,473
Endocrine System 119 | 18,512
Liver and Pancreas 118 | 18,136
Urinary Tract 118 | 18,444
Respiratory system 117 | 17,484
Skin and soft tissues 117 | 18,115

Target Family

Non-IDG 103 | 11,971
Enzyme 11 | 4,146
Kinase 4 | 634
Epigenetic 3 | 242
Ion Channel 1 | 341
Transcription Factor 1 | 1,400

GO Function

microtubule binding 123 | 123
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Microtubule-associated protein RP/EB family member 3 MAPRE3 Tbio Non-IDG -2.14681 132.5 161
Neurofilament heavy polypeptide NEFH Tbio Non-IDG -2.73883 563.3 681
MAP7 domain-containing protein 3 MAP7D3 Tbio Non-IDG -0.92082 8.05 8
Ras-related protein Rab-11A RAB11A Tbio Enzyme -2.60207 398.9 288
Golgin subfamily A member 2 GOLGA2 Tbio Non-IDG -1.94177 80.5 168
WD repeat-containing protein 81 WDR81 Tdark Non-IDG -1.18646 17.0 6
40S ribosomal protein S3 RPS3 Tbio Non-IDG -2.16121 152.6 207
Translationally-controlled tumor protein TPT1 Tbio Non-IDG -2.70459 550.0 375
Kinesin-like protein KIF18A KIF18A Tbio Non-IDG -1.37782 29.6 81
CLIP-associating protein 2 CLASP2 Tbio Non-IDG -1.22296 20.8 220