Development Level

Tbio 166 | 11,445
Tdark 26 | 6,588
Tchem 19 | 1,598
Tclin 1 | 613

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 23 | 979
abnormal embryo size 7 | 220
embryonic lethality prior to t... 7 | 278
embryonic lethality prior to o... 6 | 239
abnormal behavior 5 | 298
hyperactivity 5 | 148
abnormal bone structure 4 | 187
embryonic growth retardation 4 | 106
prenatal lethality prior to he... 4 | 87
decreased bone mineral content 3 | 151
decreased bone mineral density 3 | 126
decreased circulating glucose ... 3 | 126
decreased circulating serum al... 3 | 82
decreased total body fat amoun... 3 | 207
increased lean body mass 3 | 172
preweaning lethality, incomple... 3 | 499
abnormal behavioral response t... 2 | 66
abnormal coat-hair pigmentatio... 2 | 64
abnormal embryo turning 2 | 31
abnormal sleep behavior 2 | 70
cataract 2 | 92
cyanosis 2 | 7
decreased body length 2 | 101
decreased body weight 2 | 161
decreased circulating triglyce... 2 | 79
decreased fasted circulating g... 2 | 65
decreased grip strength 2 | 116
decreased lean body mass 2 | 135
decreased mean corpuscular vol... 2 | 79
hemorrhage 2 | 23
hypoactivity 2 | 132
increased bone mineral content 2 | 108
increased circulating alkaline... 2 | 122
increased circulating chloride... 2 | 41
increased fasted circulating g... 2 | 76
increased hematocrit 2 | 46
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
increased total body fat amoun... 2 | 134
persistence of hyaloid vascula... 2 | 33
abnormal allantois morphology 1 | 8
abnormal blood vessel morpholo... 1 | 5
abnormal chorioallantoic fusio... 1 | 8
abnormal coat- hair morphology 1 | 19
abnormal cranium morphology 1 | 36
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal heart looping 1 | 5
abnormal hindbrain development 1 | 16
abnormal left-right axis patte... 1 | 2
abnormal lens morphology 1 | 81
abnormal limb bud morphology 1 | 17
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal optic vesicle formati... 1 | 4
abnormal otic vesicle morpholo... 1 | 3
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal somite shape 1 | 5
abnormal spleen morphology 1 | 55
abnormal tail bud morphology 1 | 8
abnormal testis morphology 1 | 43
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
abnormal vitreous body morphol... 1 | 10
cardiovascular system phenotyp... 1 | 36
convulsive seizures 1 | 13
decreased anxiety-related resp... 1 | 12
decreased caudal vertebrae num... 1 | 53
decreased circulating free fat... 1 | 31
decreased heart left ventricle... 1 | 28
decreased heart rate variabili... 1 | 13
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
enlarged epididymis 1 | 31
enlarged spleen 1 | 41
impaired pupillary reflex 1 | 26
increased circulating HDL chol... 1 | 80
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased circulating sodium l... 1 | 71
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
pallor 1 | 34
polycystic kidney 1 | 15
prenatal lethality 1 | 28
scaly skin 1 | 4
short tibia 1 | 97
small testis 1 | 58
thrombocytosis 1 | 27
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Carcinoma 154 | 11,493
medulloblastoma, large-cell 115 | 6,241
ovarian cancer 114 | 8,520
glioblastoma 104 | 5,792
atypical teratoid / rhabdoid tumor 99 | 5,112
osteosarcoma 99 | 7,950
psoriasis 92 | 6,694
lung cancer 86 | 4,740
group 3 medulloblastoma 83 | 4,104
adult high grade glioma 76 | 3,801
ependymoma 74 | 4,679
Breast cancer 63 | 3,578
primitive neuroectodermal tumor 58 | 3,035
malignant mesothelioma 54 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 53 | 2,989
Astrocytoma, Pilocytic 51 | 3,081
Kidney cancer 51 | 2,613
oligodendroglioma 49 | 2,850
intraductal papillary-mucinous neoplasm (IPMN) 48 | 3,291
invasive ductal carcinoma 46 | 2,951
non-small cell lung cancer 43 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 39 | 2,955
subependymal giant cell astrocytoma 39 | 2,287
astrocytic glioma 38 | 2,597
lung carcinoma 37 | 2,843
Pick disease 35 | 1,894
lung adenocarcinoma 34 | 2,716
pancreatic cancer 34 | 2,398
breast carcinoma 33 | 1,638
colon cancer 33 | 1,478
pituitary cancer 32 | 1,972
Atopic dermatitis 30 | 952
Cancer 30 | 2,499
adrenocortical carcinoma 29 | 1,428
ductal carcinoma in situ 29 | 1,745
nasopharyngeal carcinoma 27 | 1,058
Intellectual disability 25 | 1,016
interstitial cystitis 25 | 2,312
tuberculosis 25 | 2,010
Neurodegenerative disease 24 | 414
ulcerative colitis 23 | 1,819
group 4 medulloblastoma 21 | 1,855
Alzheimer's disease 20 | 658
Endometriosis 20 | 540
Schizophrenia 20 | 1,160
Autosomal recessive predisposition 18 | 1,442
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,962
Amyotrophic lateral sclerosis 16 | 451
Cognitive delay 16 | 608
Global developmental delay 16 | 608
Mental and motor retardation 16 | 608
Multiple myeloma 16 | 1,332
chronic rhinosinusitis 16 | 512
spina bifida 16 | 1,074
Epilepsy 15 | 792
Waldenstrons macroglobulinemia 15 | 765
astrocytoma 15 | 1,146
Dull intelligence 14 | 645
Low intelligence 14 | 645
Mental Retardation 14 | 645
Mental deficiency 14 | 645
Poor school performance 14 | 645
acute quadriplegic myopathy 14 | 1,158
cystic fibrosis 14 | 1,696
diabetes mellitus 14 | 1,728
progressive supranuclear palsy 14 | 676
Muscle hypotonia 13 | 571
Neuropathy 13 | 261
Seizures 13 | 596
cutaneous lupus erythematosus 13 | 1,057
dermatomyositis 13 | 966
Down syndrome 12 | 499
Liver cancer 12 | 604
Small head 12 | 374
medulloblastoma 12 | 720
primary pancreatic ductal adenocarcinoma 12 | 1,109
Depressive disorder 11 | 409
juvenile dermatomyositis 11 | 1,187
non-small cell lung carcinoma 11 | 317
primary Sjogren syndrome 11 | 735
Anteverted nostril 10 | 191
Microcephaly 10 | 166
Prostatic Neoplasms 10 | 495
Rheumatoid arthritis 10 | 1,191
Short stature 10 | 531
acute myeloid leukemia 10 | 783
fibroadenoma 10 | 559
gastric cancer 10 | 459
non primary Sjogren syndrome sicca 10 | 891
pediatric high grade glioma 10 | 1,064
Hyperreflexia 9 | 209
Melanoma 9 | 711
Parkinson's disease 9 | 392
active Crohn's disease 9 | 922
cystic fibrosis and chronic rhinosinusitis 9 | 214
gastric carcinoma 9 | 807
hereditary spastic paraplegia 9 | 318
aldosterone-producing adenoma 8 | 665
esophageal adenocarcinoma 8 | 737
pancreatic carcinoma 8 | 562

Tissue

Endocrine System 206 | 18,159
Female tissues 203 | 17,400
Male tissues 203 | 17,142
Skin and soft tissues 202 | 17,230
Digestive Tract 201 | 17,369
Liver and Pancreas 200 | 16,750
Urinary Tract 200 | 16,678
Nervous System 199 | 16,725
Blood and immune system 198 | 16,909
Respiratory system 197 | 16,393
Cardiovascular System 188 | 15,192

Target Family

Non-IDG 180 | 12,091
Enzyme 21 | 4,145
Kinase 5 | 634
Epigenetic 3 | 242
Transcription Factor 2 | 1,400
Ion Channel 1 | 344

GO Function

microtubule binding 212 | 212
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Kinesin-like protein KIF25 KIF25 Tbio Non-IDG -0.75019 5.59 191
CAP-Gly domain-containing linker protein 1 CLIP1 Tbio Non-IDG -2.54943 343.7 221
Nuclear mitotic apparatus protein 1 NUMA1 Tbio Non-IDG -2.76544 575.8 235
Sperm-associated antigen 8 SPAG8 Tbio Non-IDG -0.96272 9.29 158
Sperm-associated antigen 5 SPAG5 Tbio Non-IDG -1.72743 51.4 136
Kinesin-like protein KIF18B KIF18B Tbio Non-IDG -0.83463 5.23 17
GAS2-like protein 3 GAS2L3 Tbio Non-IDG -0.65733 5.79 78
Adenomatous polyposis coli protein 2 APC2 Tbio Non-IDG -1.50271 33.3 93
Growth arrest-specific protein 8 GAS8 Tbio Non-IDG -1.20822 17.3 102
Echinoderm microtubule-associated protein-like 5 EML5 Tdark Non-IDG -0.47268 3.14 28