Development Level

Tbio 19 | 11,445

IMPC Phenotype

abnormal behavior 2 | 298
preweaning lethality, complete... 2 | 979
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal locomotor activation 1 | 16
abnormal pericardium morpholog... 1 | 26
abnormal placenta size 1 | 20
abnormal skin coloration 1 | 25
absent pinna reflex 1 | 23
cardiovascular system phenotyp... 1 | 36
decreased body weight 1 | 161
edema 1 | 59
embryonic growth retardation 1 | 106
hemorrhage 1 | 23
hyperactivity 1 | 148
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased circulating sodium l... 1 | 71
increased heart rate variabili... 1 | 7
increased lean body mass 1 | 172
increased or absent threshold ... 1 | 101
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
increased urine magnesium leve... 1 | 2
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
stereotypic behavior 1 | 3
trunk curl 1 | 16

Disease

Carcinoma 18 | 11,493
Kidney cancer 15 | 2,613
osteosarcoma 11 | 7,950
psoriasis 11 | 6,694
ovarian cancer 9 | 8,520
Autosomal recessive predisposition 8 | 1,442
Melanoma 7 | 711
malignant mesothelioma 7 | 3,232
Breast cancer 6 | 3,578
ulcerative colitis 6 | 1,819
Distal arthrogryposis 5 | 42
Liver cancer 5 | 604
Sensorineural hearing loss 5 | 106
Skin cancer 5 | 469
acute quadriplegic myopathy 5 | 1,158
adult high grade glioma 5 | 3,801
ependymoma 5 | 4,679
glioblastoma 5 | 5,792
lung carcinoma 5 | 2,843
Astrocytoma, Pilocytic 4 | 3,081
MYH-9 related disease 4 | 12
Myopathy 4 | 185
Nonsyndromic deafness 4 | 142
Ophthalmoplegia 4 | 106
Schizophrenia 4 | 1,160
atypical teratoid / rhabdoid tumor 4 | 5,112
diabetes mellitus 4 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
medulloblastoma, large-cell 4 | 6,241
non-small cell lung cancer 4 | 2,890
primitive neuroectodermal tumor 4 | 3,035
Blepharoptosis 3 | 231
Byzanthine arch palate 3 | 194
Duchenne muscular dystrophy 3 | 601
Focal glomerulosclerosis 3 | 37
Glomerulosclerosis, Focal Segmental 3 | 28
Myocardial Infarction 3 | 151
astrocytic glioma 3 | 2,597
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
interstitial cystitis 3 | 2,312
juvenile dermatomyositis 3 | 1,187
lung adenocarcinoma 3 | 2,716
medulloblastoma 3 | 720
pediatric high grade glioma 3 | 1,064
subependymal giant cell astrocytoma 3 | 2,287
Abnormality of metabolism/homeostasis 2 | 134
Acquired scoliosis 2 | 281
Amebiasis 2 | 21
Amyotrophic lateral sclerosis 2 | 451
Ankyloglossia 2 | 17
Arthrogryposis 2 | 54
Asymmetric Septal Hypertrophy 2 | 7
Atrial Septal Defects 2 | 85
Becker muscular dystrophy 2 | 191
Cardiac Arrhythmia 2 | 103
Cardiac conduction abnormalities 2 | 78
Cardiomyopathy 2 | 116
Cardiomyopathy, Dilated 2 | 83
Clubfoot 2 | 39
Conduction disorder of the heart 2 | 79
Congenital clubfoot 2 | 109
Congestive heart failure 2 | 113
Curvature of spine 2 | 282
Deglutition Disorders 2 | 132
Dilated cardiomyopathy 2 | 56
EKG abnormalities 2 | 78
Electrocardiogram abnormal 2 | 81
Electrocardiogram change 2 | 78
Endometrial cancer 2 | 311
Epilepsy 2 | 792
Failure to gain weight 2 | 365
Generalized muscle weakness 2 | 57
Heart failure 2 | 162
Highly variable severity 2 | 157
Hodgkin's lymphoma, nodular sclerosis 2 | 22
Hypertrophic Cardiomyopathy 2 | 117
Infantile onset 2 | 238
Large intestine cancer 2 | 126
Liver Cirrhosis, Experimental 2 | 769
Neck muscle weakness 2 | 17
Pediatric failure to thrive 2 | 365
Pigmentary iris degeneration 2 | 20
Prenatal onset 2 | 139
Proteinuria 2 | 144
Proximal muscle weakness 2 | 47
Proximal neurogenic muscle weakness 2 | 47
Seizures 2 | 596
Subaortic stenosis 2 | 9
Toeing-in 2 | 24
Variable expressivity 2 | 157
acute myeloid leukemia 2 | 783
cystic fibrosis 2 | 1,696
gastric carcinoma 2 | 807
limb girdle muscular dystrophy 2A 2 | 213
mucosa-associated lymphoid tissue lymphoma 2 | 484
oligodendroglioma 2 | 2,850
pancreatic cancer 2 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
pituitary cancer 2 | 1,972

Tissue

Endocrine System 19 | 18,159
Skin and soft tissues 19 | 17,230
Digestive Tract 18 | 17,369
Blood and immune system 17 | 16,909
Cardiovascular System 17 | 15,192
Male tissues 17 | 17,142
Female tissues 16 | 17,400
Liver and Pancreas 16 | 16,750
Nervous System 16 | 16,725
Urinary Tract 16 | 16,678
Respiratory system 14 | 16,393

Target Family

Non-IDG 18 | 12,091
Kinase 1 | 634

GO Function

microfilament motor activity 19 | 19
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myosin-4 MYH4 Tbio Non-IDG -1.81214 51.8 52
Myosin-13 MYH13 Tbio Non-IDG -1.26079 16.6 12
Myosin-2 MYH2 Tbio Non-IDG -2.14128 114.9 63
Unconventional myosin-IXb MYO9B Tbio Non-IDG -1.68591 55.7 79
Unconventional myosin-VIIa MYO7A Tbio Non-IDG -2.14713 133.5 129
Myosin-6 MYH6 Tbio Non-IDG -2.95952 901.3 45
Myosin-8 MYH8 Tbio Non-IDG -1.71003 48.7 39
Myosin-IIIa MYO3A Tbio Kinase -1.25280 20.1 130
Myosin-3 MYH3 Tbio Non-IDG -1.74714 48.2 51
Unconventional myosin-Ib MYO1B Tbio Non-IDG -1.76878 60.8 85