Development Level

Tbio 23 | 11,651
Tchem 1 | 1,388

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal clavicle morphology 1 | 6
abnormal rib morphology 1 | 10
decreased IgE level 1 | 6
decreased body weight 1 | 161
hyperactivity 1 | 148
increased grip strength 1 | 41
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 20 | 11,493
ovarian cancer 14 | 8,520
medulloblastoma, large-cell 10 | 6,241
osteosarcoma 10 | 7,950
lung cancer 9 | 4,740
atypical teratoid / rhabdoid tumor 8 | 5,112
glioblastoma 8 | 5,792
Cancer 7 | 2,499
Pick disease 7 | 1,894
acute quadriplegic myopathy 7 | 1,158
group 3 medulloblastoma 7 | 4,104
astrocytic glioma 6 | 2,597
ependymoma 6 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
juvenile dermatomyositis 6 | 1,187
malignant mesothelioma 6 | 3,232
primitive neuroectodermal tumor 6 | 3,035
psoriasis 6 | 6,694
Amyotrophic lateral sclerosis 5 | 451
Kidney cancer 5 | 2,613
Multiple myeloma 5 | 1,332
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
oligodendroglioma 5 | 2,850
subependymal giant cell astrocytoma 5 | 2,287
Depressive disorder 4 | 409
Neurodegenerative disease 4 | 414
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
Anxiety 3 | 136
Anxiety disease 3 | 113
Cognitive delay 3 | 608
Frontotemporal dementia 3 | 51
Global developmental delay 3 | 608
Mental and motor retardation 3 | 608
Muscle hypotonia 3 | 571
Myopathy 3 | 185
Neurogenic Muscular Atrophy 3 | 139
Neurogenic muscle atrophy, especially in the lower limbs 3 | 139
Rheumatoid arthritis 3 | 1,191
Skeletal muscle atrophy 3 | 139
adult high grade glioma 3 | 3,801
cystic fibrosis 3 | 1,696
dermatomyositis 3 | 966
diabetes mellitus 3 | 1,728
muscle degeneration 3 | 139
non-small cell lung cancer 3 | 2,890
pancreatic cancer 3 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pituitary cancer 3 | 1,972
progressive supranuclear palsy 3 | 676
Adenocarcinoma of lung 2 | 142
Adult onset 2 | 82
Alcoholic Intoxication, Chronic 2 | 289
Breast cancer 2 | 3,578
Congenital deafness 2 | 185
Creatine phosphokinase serum increased 2 | 110
Deafness 2 | 198
Down syndrome 2 | 499
Dysarthria 2 | 192
Dyspnea 2 | 76
Elevated creatine kinase 2 | 110
Endometrial stromal sarcoma 2 | 15
Epilepsy 2 | 792
Failure to gain weight 2 | 365
Fatigue 2 | 182
Fetal Growth Retardation 2 | 189
Frontal bossing 2 | 157
Generalized muscle weakness 2 | 57
Hearing Loss, Partial 2 | 185
Infant, Small for Gestational Age 2 | 176
Infertility 2 | 188
Intrauterine retardation 2 | 176
Mental Depression 2 | 333
Mesothelioma, Malignant 2 | 105
Mood swings 2 | 77
Muscle Cramp 2 | 55
Muscle Spasticity 2 | 195
Muscle biopsy shows dystrophic changes 2 | 39
Muscular dystrophy 2 | 75
Nerve Degeneration 2 | 121
Neuro-degenerative disease 2 | 43
Neurodegenerative Disorders 2 | 79
Nystagmus 2 | 317
Pain 2 | 103
Paralysed 2 | 42
Pediatric failure to thrive 2 | 365
Respiratory Failure 2 | 104
Sarcoma 2 | 62
Seizures 2 | 596
Short stature 2 | 531
Uranostaphyloschisis 2 | 167
Waldenstrons macroglobulinemia 2 | 765
atypical teratoid/rhabdoid tumor 2 | 357
colon cancer 2 | 1,478
esophageal adenocarcinoma 2 | 737
hearing impairment 2 | 199
lung adenocarcinoma 2 | 2,716
nasopharyngeal carcinoma 2 | 1,058
pediatric high grade glioma 2 | 1,064
spina bifida 2 | 1,074
tuberculosis 2 | 2,010

Tissue

Blood and immune system 24 | 16,909
Endocrine System 24 | 18,159
Female tissues 24 | 17,400
Nervous System 24 | 16,725
Respiratory system 24 | 16,393
Urinary Tract 24 | 16,678
Cardiovascular System 23 | 15,192
Digestive Tract 23 | 17,369
Liver and Pancreas 23 | 16,750
Male tissues 23 | 17,142
Skin and soft tissues 23 | 17,230

Target Family

Non-IDG 15 | 12,091
Enzyme 5 | 4,145
Transcription Factor 3 | 1,400
Epigenetic 1 | 242

GO Function

miRNA binding 24 | 24
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 346 ZNF346 Tbio Non-IDG -2.28393 188.7 213
Protein argonaute-2 AGO2 Tbio Non-IDG -2.97243 867.1 202
Protein argonaute-1 AGO1 Tbio Non-IDG -2.22336 158.4 203
RNA-binding protein 4 RBM4 Tbio Non-IDG -1.71130 51.9 162
POU domain, class 5, transcription factor 1 POU5F1 Tbio Transcription Factor -3.31332 2140.4 983
Transcription factor SOX-2 SOX2 Tbio Transcription Factor -3.20671 1563.0 1171
Protein argonaute-3 AGO3 Tbio Non-IDG -1.30752 14.4 127
Synaptic functional regulator FMR1 FMR1 Tbio Epigenetic -3.38241 2443.7 484
Heterogeneous nuclear ribonucleoprotein A1 HNRNPA1 Tchem Non-IDG -2.59374 376.5 328
E3 ubiquitin-protein ligase TRIM71 TRIM71 Tbio Enzyme -1.41796 23.0 124