Development Level

Tbio 32 | 11,445
Tchem 18 | 1,598
Tdark 10 | 6,588
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 3 | 979
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
abnormal seminal vesicle morph... 2 | 114
decreased body length 2 | 101
decreased vertical activity 2 | 208
hypoactivity 2 | 132
increased mean corpuscular vol... 2 | 92
thrombocytosis 2 | 27
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal heart morphology 1 | 162
abnormal locomotor behavior 1 | 24
abnormal lymph node morphology 1 | 3
abnormal pelvic girdle bone mo... 1 | 12
abnormal rib morphology 1 | 10
abnormal tail morphology 1 | 25
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
abnormal vertebral arch morpho... 1 | 9
abnormal vibrissa morphology 1 | 25
corneal opacity 1 | 32
decreased body weight 1 | 161
decreased caudal vertebrae num... 1 | 53
decreased circulating aspartat... 1 | 34
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased leukocyte cell numbe... 1 | 73
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating chloride... 1 | 41
increased circulating phosphat... 1 | 26
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased mean platelet volume 1 | 45
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
narrow eye opening 1 | 12
prolonged ST segment 1 | 36
short tibia 1 | 97
vertebral fusion 1 | 23

Disease

Carcinoma 52 | 11,493
osteosarcoma 35 | 7,950
ovarian cancer 31 | 8,520
glioblastoma 25 | 5,792
atypical teratoid / rhabdoid tumor 24 | 5,112
lung cancer 22 | 4,740
medulloblastoma, large-cell 21 | 6,241
intraductal papillary-mucinous neoplasm (IPMN) 20 | 3,291
Breast cancer 19 | 3,578
malignant mesothelioma 19 | 3,232
psoriasis 19 | 6,694
Cancer 18 | 2,499
Kidney cancer 18 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,989
invasive ductal carcinoma 18 | 2,951
adult high grade glioma 17 | 3,801
ependymoma 17 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,955
non-small cell lung cancer 17 | 2,890
primitive neuroectodermal tumor 17 | 3,035
ulcerative colitis 17 | 1,819
Astrocytoma, Pilocytic 14 | 3,081
group 3 medulloblastoma 14 | 4,104
Autosomal recessive predisposition 13 | 1,442
cystic fibrosis 13 | 1,696
ductal carcinoma in situ 13 | 1,745
interstitial cystitis 13 | 2,312
pancreatic cancer 13 | 2,398
astrocytic glioma 12 | 2,597
lung carcinoma 12 | 2,843
group 4 medulloblastoma 11 | 1,855
oligodendroglioma 11 | 2,850
pituitary cancer 11 | 1,972
Alzheimer's disease 10 | 658
lung adenocarcinoma 10 | 2,716
primary pancreatic ductal adenocarcinoma 10 | 1,109
adrenocortical carcinoma 9 | 1,428
breast carcinoma 9 | 1,638
Endometriosis 8 | 540
Melanoma 8 | 711
colon cancer 8 | 1,478
diabetes mellitus 8 | 1,728
Pick disease 7 | 1,894
Skin cancer 7 | 469
active Crohn's disease 7 | 922
pediatric high grade glioma 7 | 1,064
Breast Neoplasms 6 | 445
Hypertension 6 | 396
Kidney disease 6 | 430
Liver Cirrhosis, Experimental 6 | 769
Mammary Neoplasms 6 | 425
Multiple myeloma 6 | 1,332
Rheumatoid arthritis 6 | 1,191
acute quadriplegic myopathy 6 | 1,158
cutaneous lupus erythematosus 6 | 1,057
interstitial lung disease 6 | 298
juvenile dermatomyositis 6 | 1,187
nasopharyngeal carcinoma 6 | 1,058
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
tuberculosis 6 | 2,010
Arthritis 5 | 290
Atherosclerosis 5 | 291
Carcinoma, Hepatocellular 5 | 228
Cerebrovascular disease 5 | 238
Coronary artery disease 5 | 268
Degenerative disc disease 5 | 35
Liver carcinoma 5 | 240
Neurodegenerative disease 5 | 414
Pre-Eclampsia 5 | 68
Schizophrenia 5 | 1,160
gastric carcinoma 5 | 807
medulloblastoma 5 | 720
periodontitis 5 | 293
primary Sjogren syndrome 5 | 735
Acquired metabolic disease 4 | 336
Anemia 4 | 365
Asthma 4 | 385
Atopic dermatitis 4 | 952
Cerebral Hemorrhage 4 | 42
Down syndrome 4 | 499
Hypersensitivity reaction type II disease 4 | 253
Myocardial Infarction 4 | 151
Neoplasm Invasiveness 4 | 161
Osteoarthritis 4 | 184
Prostatic Neoplasms 4 | 495
Short stature 4 | 531
Waldenstrons macroglobulinemia 4 | 765
acute myeloid leukemia 4 | 783
astrocytoma 4 | 1,146
esophageal adenocarcinoma 4 | 737
head and neck cancer and chronic obstructive pulmonary disease 4 | 239
progressive supranuclear palsy 4 | 676
subependymal giant cell astrocytoma 4 | 2,287
Bipolar Disorder 3 | 666
Duchenne muscular dystrophy 3 | 601
Epilepsy 3 | 792
Heart disease 3 | 306
aldosterone-producing adenoma 3 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
spina bifida 3 | 1,074

Tissue

Endocrine System 62 | 18,159
Female tissues 60 | 17,400
Nervous System 59 | 16,725
Blood and immune system 58 | 16,909
Male tissues 58 | 17,142
Skin and soft tissues 58 | 17,230
Digestive Tract 57 | 17,369
Urinary Tract 57 | 16,678
Liver and Pancreas 56 | 16,750
Respiratory system 56 | 16,393
Cardiovascular System 55 | 15,192

Target Family

Enzyme 52 | 4,145
Non-IDG 9 | 12,091
Transcription Factor 1 | 1,400

GO Function

metallopeptidase activity 62 | 62
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

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