Development Level

Tbio 60 | 11,178
Tchem 43 | 1,885
Tdark 11 | 6,569
Tclin 1 | 612

Collection

Ion Channel: IDG Consortium (T... 2 | 99

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal heart morphology 3 | 162
preweaning lethality, incomple... 3 | 499
abnormal eye morphology 2 | 68
abnormal skin coloration 2 | 25
abnormal tail morphology 2 | 25
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating aspartat... 2 | 34
decreased circulating phosphat... 2 | 27
decreased circulating triglyce... 2 | 79
decreased total body fat amoun... 2 | 207
enlarged heart 2 | 210
increased heart weight 2 | 62
increased total body fat amoun... 2 | 134
short tibia 2 | 97
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal cranium morphology 1 | 36
abnormal esophagus morphology 1 | 5
abnormal femur morphology 1 | 14
abnormal hair texture 1 | 4
abnormal incisor morphology 1 | 4
abnormal joint morphology 1 | 23
abnormal locomotor behavior 1 | 24
abnormal lymph node morphology 1 | 3
abnormal maxilla morphology 1 | 17
abnormal pancreas morphology 1 | 13
abnormal radius morphology 1 | 8
abnormal seminal vesicle morph... 1 | 114
abnormal sensory capabilities-... 1 | 8
abnormal thyroid gland morphol... 1 | 3
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
abnormal trachea morphology 1 | 3
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 18
abnormal vertebral arch morpho... 1 | 9
abnormal vibrissa morphology 1 | 25
absent lymph nodes 1 | 3
anophthalmia 1 | 33
athymia 1 | 2
cataract 1 | 92
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased vertical activity 1 | 208
enlarged spleen 1 | 41
hydrometra 1 | 53
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating potassiu... 1 | 29
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
long tail 1 | 1
mammalian phenotype 1 | 17
small superior vagus ganglion 1 | 74
thick tail 1 | 1

Disease

Carcinoma 43 | 11,192
osteosarcoma 27 | 7,766
ovarian cancer 23 | 8,297
Kidney cancer 17 | 2,548
medulloblastoma, large-cell 17 | 6,086
psoriasis 15 | 6,514
Breast cancer 14 | 3,469
ependymoma 14 | 4,559
atypical teratoid / rhabdoid tumor 12 | 4,971
glioblastoma 12 | 5,635
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,872
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,902
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,204
invasive ductal carcinoma 11 | 2,867
non-small cell lung cancer 11 | 2,799
adrenocortical carcinoma 10 | 1,385
lung cancer 10 | 4,607
adult high grade glioma 9 | 3,701
cystic fibrosis 9 | 1,629
interstitial cystitis 9 | 2,237
malignant mesothelioma 9 | 3,135
oligodendroglioma 9 | 2,768
primitive neuroectodermal tumor 9 | 2,957
ulcerative colitis 9 | 1,765
group 4 medulloblastoma 8 | 1,806
pituitary cancer 8 | 1,915
Acquired metabolic disease 7 | 329
Astrocytoma, Pilocytic 7 | 3,006
Autosomal recessive predisposition 7 | 1,407
Melanoma 7 | 689
Skin cancer 7 | 451
Weill-Marchesani syndrome 7 | 14
astrocytic glioma 7 | 2,530
colon cancer 7 | 1,428
diabetes mellitus 7 | 1,683
pancreatic cancer 7 | 2,322
Alzheimer's disease 6 | 640
atypical teratoid/rhabdoid tumor 6 | 349
group 3 medulloblastoma 6 | 4,002
lung adenocarcinoma 6 | 2,627
lung carcinoma 6 | 2,755
Liver cancer 5 | 589
Multiple myeloma 5 | 1,296
Schizophrenia 5 | 1,136
breast carcinoma 5 | 1,589
ductal carcinoma in situ 5 | 1,686
gastric carcinoma 5 | 781
primary pancreatic ductal adenocarcinoma 5 | 1,071
Down syndrome 4 | 480
Pick disease 4 | 1,856
Waldenstrons macroglobulinemia 4 | 742
juvenile dermatomyositis 4 | 1,147
medulloblastoma 4 | 702
nasopharyngeal carcinoma 4 | 1,024
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,911
pediatric high grade glioma 4 | 1,035
subependymal giant cell astrocytoma 4 | 2,230
Arthritis 3 | 276
Atopic dermatitis 3 | 915
Brachydactyly 3 | 154
Cancer 3 | 2,388
Congestive heart failure 3 | 109
Crohn's disease 3 | 311
Dementia 3 | 172
Duchenne muscular dystrophy 3 | 587
Ehlers-Danlos syndrome 3 | 43
Endometriosis 3 | 521
Hereditary spherocytosis type 2 3 | 18
Hydrolethalus syndrome 3 | 126
Osteoarthritis 3 | 179
Rheumatoid arthritis 3 | 1,156
Short stature 3 | 514
Tracheal stenosis 3 | 23
Type 2 diabetes mellitus 3 | 268
active Crohn's disease 3 | 882
head and neck cancer 3 | 263
posterior fossa group A ependymoma 3 | 456
sonic hedgehog group medulloblastoma 3 | 459
Alzheimer Disease 2 | 80
Anemia 2 | 353
Atherosclerosis 2 | 276
Cerebrovascular disease 2 | 223
Contracture 2 | 95
Coronary artery disease 2 | 253
Edwards syndrome 2 | 15
Hepatomegaly 2 | 280
Neurodegenerative disease 2 | 402
Parkinson's disease 2 | 378
Short nose 2 | 127
Small nose 2 | 127
acute quadriplegic myopathy 2 | 1,133
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 492
esophageal adenocarcinoma 2 | 696
fibroadenoma 2 | 538
glioblastoma multiforme 2 | 139
non diabetic and post-ischemic heart failure 2 | 195
posterior fossa group B ependymoma 2 | 406
progressive supranuclear palsy 2 | 656
spina bifida 2 | 1,053
substance-related disorder 2 | 156

Tissue

Endocrine System 112 | 18,159
Female tissues 111 | 17,400
Male tissues 107 | 17,142
Urinary Tract 107 | 16,678
Blood and immune system 106 | 16,909
Digestive Tract 106 | 17,369
Skin and soft tissues 105 | 17,230
Liver and Pancreas 103 | 16,750
Nervous System 101 | 16,725
Respiratory system 100 | 16,393
Cardiovascular System 88 | 15,192

Target Family

Enzyme 96 | 4,145
Non-IDG 15 | 12,091
Ion Channel 4 | 344

GO Function

metalloendopeptidase activity 115 | 115
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

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