Development Level

Tbio 57 | 10,625
Tchem 40 | 1,890
Tdark 14 | 7,003
Tclin 1 | 602

Collection

Eligible Ion Channel Proteins 3 | 117

IMPC Term

preweaning lethality, complete... 3 | 633
decreased body weight 2 | 174
decreased heart weight 2 | 44
hyperactivity 2 | 108
short tibia 2 | 82
abnormal behavior 1 | 226
abnormal body size 1 | 1
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal cranium morphology 1 | 32
abnormal esophagus morphology 1 | 4
abnormal eye morphology 1 | 38
abnormal femur morphology 1 | 14
abnormal hair texture 1 | 4
abnormal heart morphology 1 | 51
abnormal incisor morphology 1 | 3
abnormal joint morphology 1 | 14
abnormal lymph node morphology 1 | 3
abnormal maxilla morphology 1 | 16
abnormal pancreas morphology 1 | 6
abnormal radius morphology 1 | 8
abnormal retinal pigmentation 1 | 61
abnormal seminal vesicle morph... 1 | 47
abnormal skin coloration 1 | 18
abnormal tail morphology 1 | 17
abnormal thyroid gland morphol... 1 | 3
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
abnormal trachea morphology 1 | 3
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 14
abnormal vertebral arch morpho... 1 | 9
abnormal vibrissa morphology 1 | 17
absent lymph nodes 1 | 3
anophthalmia 1 | 20
athymia 1 | 1
cataract 1 | 26
decreased CD11b-low dendritic ... 1 | 3
decreased CD4-positive, CD25-p... 1 | 24
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 53
decreased circulating amylase ... 1 | 24
decreased circulating aspartat... 1 | 27
decreased circulating calcium ... 1 | 33
decreased circulating choleste... 1 | 85
decreased circulating creatini... 1 | 31
decreased circulating free fat... 1 | 39
decreased circulating glucose ... 1 | 121
decreased circulating phosphat... 1 | 15
decreased circulating triglyce... 1 | 83
decreased total body fat amoun... 1 | 186
enlarged heart 1 | 111
enlarged spleen 1 | 26
increased CD11b-high dendritic... 1 | 5
increased body weight 1 | 42
increased circulating alkaline... 1 | 119
increased circulating amylase ... 1 | 13
increased circulating potassiu... 1 | 31
increased exploration in new e... 1 | 56
increased heart weight 1 | 37
preweaning lethality, incomple... 1 | 260
short tail 1 | 4
thick tail 1 | 1

Disease

osteosarcoma 57 | 7,933
ovarian cancer 47 | 8,484
psoriasis 37 | 6,685
glioblastoma 34 | 5,572
atypical teratoid / rhabdoid tumor 32 | 4,369
medulloblastoma, large-cell 32 | 6,234
malignant mesothelioma 28 | 3,162
ulcerative colitis 28 | 2,087
invasive ductal carcinoma 27 | 2,950
non-small cell lung cancer 27 | 2,798
lung cancer 26 | 4,466
Breast cancer 24 | 3,094
Cancer 23 | 2,346
Carcinoma 22 | 2,147
interstitial cystitis 22 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,956
lung carcinoma 22 | 2,844
lung adenocarcinoma 21 | 2,713
pilocytic astrocytoma 21 | 3,086
intraductal papillary-mucinous neoplasm (IPMN) 20 | 3,289
pancreatic cancer 20 | 2,300
pediatric high grade glioma 20 | 2,712
cystic fibrosis 19 | 1,665
ductal carcinoma in situ 19 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,988
oligodendroglioma 18 | 2,849
primitive neuroectodermal tumor 18 | 3,031
astrocytic glioma 17 | 2,241
colon cancer 17 | 1,475
ependymoma 17 | 2,514
group 4 medulloblastoma 16 | 1,875
adrenocortical carcinoma 15 | 1,427
primary pancreatic ductal adenocarcinoma 15 | 1,271
cutaneous lupus erythematosus 14 | 1,056
posterior fossa group A ependymoma 14 | 1,511
breast carcinoma 13 | 1,614
adult high grade glioma 12 | 2,148
nasopharyngeal carcinoma 12 | 1,056
pituitary cancer 12 | 1,972
Alzheimer's disease 11 | 644
diabetes mellitus 11 | 1,663
Atopic dermatitis 10 | 944
posterior fossa group B ependymoma 10 | 1,530
sonic hedgehog group medulloblastoma 10 | 1,482
Arthritis 9 | 248
IGA Glomerulonephritis 9 | 454
Rheumatoid Arthritis 9 | 1,160
inflammatory breast cancer 9 | 404
periodontitis 9 | 269
subependymal giant cell astrocytoma 9 | 2,287
Endometriosis 8 | 535
Mammary Neoplasms 8 | 410
Weill-Marchesani syndrome 8 | 14
active Crohn's disease 8 | 918
atypical teratoid/rhabdoid tumor 8 | 1,095
esophageal adenocarcinoma 8 | 737
gastric carcinoma 8 | 832
group 3 medulloblastoma 8 | 2,254
head and neck cancer and chronic obstructive pulmonary disease 8 | 237
medulloblastoma 8 | 1,524
non-small cell lung carcinoma 8 | 413
Pick disease 7 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
primary Sjogren syndrome 7 | 789
Asthma 6 | 349
Atherosclerosis 6 | 275
Down syndrome 6 | 548
Hypertension 6 | 287
Liver Cirrhosis, Experimental 6 | 108
Neoplasm Invasiveness 6 | 127
Neurodegenerative disease 6 | 383
Spontaneous abortion 6 | 108
tuberculosis 6 | 1,557
Coronary artery disease 5 | 240
Craniofacial Abnormalities 5 | 147
Degenerative disc disease 5 | 28
Multiple myeloma 5 | 1,327
Osteoarthritis 5 | 96
Synovitis 5 | 38
Vascular disease 5 | 281
Waldenstrons macroglobulinemia 5 | 765
head and neck cancer 5 | 270
non primary Sjogren syndrome sicca 5 | 840
sarcoidosis 5 | 358
Brachydactyly 4 | 52
Cerebrovascular disease 4 | 231
Chronic obstructive pulmonary disease 4 | 146
Colonic Neoplasms 4 | 126
Dentin dysplasia 4 | 19
Dentinogenesis imperfecta 4 | 24
Duchenne muscular dystrophy 4 | 602
Kidney disease 4 | 396
Liver carcinoma 4 | 217
Lung disease 4 | 132
Neoplasm Metastasis 4 | 138
Prostatic Neoplasms 4 | 471
acute quadriplegic myopathy 4 | 1,157
aldosterone-producing adenoma 4 | 664
juvenile dermatomyositis 4 | 1,189
mucosa-associated lymphoid tissue lymphoma 4 | 480

Tissue

Female tissues 111 | 18,647
Digestive Tract 110 | 18,473
Endocrine System 109 | 18,512
Male tissues 109 | 17,969
Urinary Tract 109 | 18,444
Nervous System 108 | 18,561
Skin and soft tissues 108 | 18,115
Liver and Pancreas 107 | 18,136
Blood and immune system 106 | 17,995
Cardiovascular System 105 | 17,958
Respiratory system 104 | 17,484

Target Family

Enzyme 93 | 4,146
Non-IDG 15 | 11,971
Ion Channel 4 | 341

GO Function

metalloendopeptidase activity 112 | 112
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Tolloid-like protein 1 TLL1 Tbio Non-IDG -1.40066 23.4 60
Macrophage metalloelastase MMP12 Tchem Enzyme 0.00000 382
Nardilysin NRDC Tbio Enzyme -1.64244 49.9 83
Bone morphogenetic protein 1 BMP1 Tchem Non-IDG -2.32178 220.1 155
Matrix metalloproteinase-9 MMP9 Tchem Enzyme -3.90528 8199.7 1129
A disintegrin and metalloproteinase with thrombospondin motifs 3 ADAMTS3 Tbio Enzyme -0.45918 3.20 40
Insulin-degrading enzyme IDE Tchem Enzyme -2.54789 384.2 283
A disintegrin and metalloproteinase with thrombospondin motifs 4 ADAMTS4 Tchem Enzyme -1.59386 46.6 337
Disintegrin and metalloproteinase domain-containing protein 19 ADAM19 Tbio Enzyme -1.55795 41.8 160