Development Level

Tbio 938 | 10,625
Tdark 688 | 7,003
Tchem 208 | 1,890
Tclin 83 | 602

Collection

Eligible Kinase Proteins 20 | 134
Eligible Ion Channel Proteins 10 | 117
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 59 | 633
preweaning lethality, incomple... 31 | 260
abnormal behavior 25 | 226
decreased total body fat amoun... 20 | 186
embryonic lethality prior to o... 19 | 148
embryonic lethality prior to t... 17 | 187
decreased lean body mass 16 | 195
hypoactivity 16 | 89
enlarged heart 15 | 111
increased bone mineral content 14 | 92
decreased bone mineral density 13 | 126
decreased circulating glucose ... 13 | 121
abnormal bone structure 12 | 131
decreased bone mineral content 12 | 157
decreased circulating triglyce... 12 | 83
decreased grip strength 12 | 123
abnormal embryo size 11 | 112
decreased circulating serum al... 11 | 79
increased mean corpuscular vol... 11 | 91
abnormal lens morphology 10 | 73
decreased body weight 10 | 174
decreased circulating HDL chol... 10 | 77
hyperactivity 10 | 108
increased circulating alkaline... 10 | 119
abnormal retina morphology 9 | 100
decreased body length 9 | 108
increased circulating sodium l... 9 | 71
increased lean body mass 9 | 107
increased or absent threshold ... 9 | 128
abnormal coat/hair pigmentatio... 8 | 54
increased bone mineral density 8 | 52
abnormal bone mineralization 7 | 55
decreased blood urea nitrogen ... 7 | 31
decreased circulating choleste... 7 | 85
decreased lumbar vertebrae num... 7 | 62
decreased prepulse inhibition 7 | 52
decreased rib number 7 | 59
increased fasted circulating g... 7 | 68
increased mean corpuscular hem... 7 | 93
increased sacral vertebrae num... 7 | 62
prenatal lethality prior to he... 7 | 64
short tibia 7 | 82
abnormal gait 6 | 51
abnormal heart morphology 6 | 51
decreased circulating LDL chol... 6 | 37
decreased circulating amylase ... 6 | 24
decreased circulating free fat... 6 | 39
decreased leukocyte cell numbe... 6 | 54
impaired glucose tolerance 6 | 52
increased circulating HDL chol... 6 | 63
increased circulating iron lev... 6 | 25
increased total body fat amoun... 6 | 57
abnormal seminal vesicle morph... 5 | 47
abnormal spleen morphology 5 | 36
decreased circulating insulin ... 5 | 75
decreased erythrocyte cell num... 5 | 43
decreased fasted circulating g... 5 | 49
impaired righting response 5 | 19
increased circulating potassiu... 5 | 31
increased heart weight 5 | 37
increased startle reflex 5 | 38
male infertility 5 | 62
narrow eye opening 5 | 15
abnormal behavioral response t... 4 | 52
abnormal cranium morphology 4 | 32
abnormal femur morphology 4 | 14
abnormal retinal blood vessel ... 4 | 18
abnormal rib morphology 4 | 28
abnormal vibrissa morphology 4 | 17
cataract 4 | 26
decreased CD4-positive, CD25-p... 4 | 24
decreased circulating alanine ... 4 | 53
decreased circulating calcium ... 4 | 33
decreased circulating chloride... 4 | 32
decreased circulating total pr... 4 | 41
decreased eosinophil cell numb... 4 | 41
decreased hematocrit 4 | 25
decreased hemoglobin content 4 | 53
decreased startle reflex 4 | 48
enlarged lymph nodes 4 | 27
increased blood urea nitrogen ... 4 | 44
increased circulating aspartat... 4 | 17
increased circulating choleste... 4 | 53
increased circulating phosphat... 4 | 24
increased exploration in new e... 4 | 56
increased grip strength 4 | 83
increased hemoglobin content 4 | 45
limb grasping 4 | 35
persistence of hyaloid vascula... 4 | 22
small testis 4 | 37
small thymus 4 | 11
vertebral fusion 4 | 23
abnormal cornea morphology 3 | 24
abnormal epididymis morphology 3 | 31
abnormal sleep behavior 3 | 63
decreased NK T cell number 3 | 28
decreased circulating iron lev... 3 | 25
increased circulating fructosa... 3 | 11
increased hematocrit 3 | 36
tremors 3 | 34

Disease

osteosarcoma 945 | 7,933
ovarian cancer 873 | 8,484
medulloblastoma, large-cell 642 | 6,234
psoriasis 587 | 6,685
glioblastoma 560 | 5,572
atypical teratoid / rhabdoid tumor 459 | 4,369
lung cancer 439 | 4,466
primitive neuroectodermal tumor 363 | 3,031
malignant mesothelioma 323 | 3,162
intraductal papillary-mucinous neoplasm (IPMN) 309 | 3,289
Breast cancer 306 | 3,094
oligodendroglioma 299 | 2,849
intraductal papillary-mucinous adenoma (IPMA) 289 | 2,956
Carcinoma 285 | 2,147
pilocytic astrocytoma 282 | 3,086
group 3 medulloblastoma 281 | 2,254
intraductal papillary-mucinous carcinoma (IPMC) 279 | 2,988
pediatric high grade glioma 276 | 2,712
invasive ductal carcinoma 273 | 2,950
ependymoma 265 | 2,514
lung carcinoma 259 | 2,844
group 4 medulloblastoma 247 | 1,875
non-small cell lung cancer 236 | 2,798
astrocytic glioma 234 | 2,241
lung adenocarcinoma 229 | 2,713
Cancer 218 | 2,346
pancreatic cancer 212 | 2,300
subependymal giant cell astrocytoma 211 | 2,287
Pick disease 208 | 1,893
adult high grade glioma 206 | 2,148
interstitial cystitis 201 | 2,299
ulcerative colitis 198 | 2,087
pituitary cancer 194 | 1,972
tuberculosis 169 | 1,557
pancreatic ductal adenocarcinoma liver metastasis 162 | 1,795
medulloblastoma 161 | 1,524
cystic fibrosis 159 | 1,665
astrocytoma 154 | 1,493
ductal carcinoma in situ 154 | 1,745
adrenocortical carcinoma 148 | 1,427
breast carcinoma 147 | 1,614
sonic hedgehog group medulloblastoma 145 | 1,482
colon cancer 138 | 1,475
posterior fossa group A ependymoma 137 | 1,511
posterior fossa group B ependymoma 135 | 1,530
juvenile dermatomyositis 118 | 1,189
acute quadriplegic myopathy 116 | 1,157
Rheumatoid Arthritis 114 | 1,160
primary pancreatic ductal adenocarcinoma 112 | 1,271
Multiple myeloma 109 | 1,327
spina bifida 108 | 1,064
atypical teratoid/rhabdoid tumor 106 | 1,095
diabetes mellitus 102 | 1,663
non primary Sjogren syndrome sicca 93 | 840
nasopharyngeal carcinoma 91 | 1,056
cutaneous lupus erythematosus 90 | 1,056
active Crohn's disease 87 | 918
tuberculosis and treatment for 6 months 86 | 686
acute myeloid leukemia 84 | 780
Atopic dermatitis 83 | 944
dermatomyositis 83 | 933
primary Sjogren syndrome 81 | 789
progressive supranuclear palsy 78 | 674
aldosterone-producing adenoma 76 | 664
gastric carcinoma 73 | 832
hepatocellular carcinoma 64 | 532
gastric cancer 63 | 430
Alzheimer's disease 62 | 644
esophageal adenocarcinoma 61 | 737
pancreatic carcinoma 59 | 567
Waldenstrons macroglobulinemia 58 | 765
Duchenne muscular dystrophy 55 | 602
Schizophrenia 55 | 501
Intellectual disability 52 | 573
Amyotrophic Lateral Sclerosis 50 | 431
Obesity 50 | 616
fibroadenoma 50 | 557
Down syndrome 49 | 548
chronic rhinosinusitis 49 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 48 | 499
Endometriosis 47 | 535
Prostatic Neoplasms 46 | 471
IGA Glomerulonephritis 42 | 454
Mammary Neoplasms 42 | 410
active ulcerative colitis 42 | 477
Asthma 41 | 349
Multiple Sclerosis 40 | 498
Autistic Disorder 38 | 320
mucosa-associated lymphoid tissue lymphoma 38 | 480
inflammatory breast cancer 37 | 404
glioblastoma multiforme 36 | 347
Stomach Neoplasms 35 | 282
sarcoidosis 35 | 358
Acquired metabolic disease 34 | 267
Crohn's disease 34 | 304
Parkinson's disease 34 | 364
head and neck cancer 33 | 270
hereditary spastic paraplegia 33 | 313
facioscapulohumeral dystrophy 32 | 286
non-small cell lung carcinoma 31 | 413

Tissue

Nervous System 1,872 | 18,561
Female tissues 1,869 | 18,647
Digestive Tract 1,866 | 18,473
Endocrine System 1,865 | 18,512
Urinary Tract 1,864 | 18,444
Liver and Pancreas 1,861 | 18,136
Cardiovascular System 1,860 | 17,958
Blood and immune system 1,856 | 17,995
Male tissues 1,855 | 17,969
Skin and soft tissues 1,839 | 18,115
Respiratory system 1,827 | 17,484

Target Family

Transcription Factor 652 | 1,400
Enzyme 559 | 4,146
Non-IDG 500 | 11,971
Kinase 111 | 634
Epigenetic 31 | 242
Ion Channel 26 | 341
Transporter 23 | 473
TF/Epigenetic 12 | 38
GPCR 3 | 406

GO Function

metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Zinc finger protein 485 ZNF485 Tdark Transcription Factor 0.00000 48
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Interferon regulatory factor 2-binding protein 1 IRF2BP1 Tdark Non-IDG -0.29200 1.63 121
Lysine-specific demethylase 3B KDM3B Tbio Epigenetic -0.92399 9.25 269
Zinc finger protein 148 ZNF148 Tbio Transcription Factor -1.71996 60.7 178
V(D)J recombination-activating protein 1 RAG1 Tbio Non-IDG -3.00063 1061.1 65
N-acetylated-alpha-linked acidic dipeptidase-like protein NAALADL1 Tbio Enzyme -1.30374 25.3 78