Development Level

Tbio 1,257 | 11,445
Tdark 711 | 6,588
Tchem 204 | 1,598
Tclin 84 | 613

Collection

RFA-RM-18-021 30 | 328
Kinase: IDG Consortium (Target... 21 | 125
Ion Channel: IDG Consortium (T... 8 | 99
Kinase: IDG Consortium (Comple... 8 | 37
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 111 | 979
preweaning lethality, incomple... 74 | 499
abnormal behavior 43 | 298
embryonic lethality prior to o... 34 | 239
embryonic lethality prior to t... 34 | 278
abnormal embryo size 31 | 220
abnormal bone structure 30 | 187
increased lean body mass 28 | 172
enlarged heart 27 | 210
decreased total body fat amoun... 26 | 207
hypoactivity 25 | 132
abnormal heart morphology 21 | 162
decreased vertical activity 21 | 208
hyperactivity 21 | 148
increased bone mineral content 18 | 108
decreased body weight 17 | 161
decreased circulating glucose ... 17 | 126
abnormal seminal vesicle morph... 16 | 114
short tibia 16 | 97
decreased body length 15 | 101
decreased bone mineral density 14 | 126
male infertility 14 | 123
decreased bone mineral content 13 | 151
decreased lean body mass 13 | 135
increased bone mineral density 13 | 72
increased circulating HDL chol... 13 | 80
prenatal lethality prior to he... 13 | 87
abnormal spleen morphology 12 | 55
cataract 12 | 92
embryonic growth retardation 12 | 106
impaired glucose tolerance 12 | 75
increased circulating sodium l... 12 | 71
increased fasted circulating g... 12 | 76
increased mean corpuscular vol... 12 | 92
increased total body fat amoun... 12 | 134
abnormal kidney morphology 11 | 65
increased startle reflex 11 | 112
abnormal lens morphology 10 | 81
decreased circulating triglyce... 10 | 79
decreased lymphocyte cell numb... 10 | 83
edema 10 | 59
small superior vagus ganglion 10 | 74
small testis 10 | 58
abnormal behavioral response t... 9 | 66
decreased circulating choleste... 9 | 93
decreased circulating insulin ... 9 | 76
decreased grip strength 9 | 116
decreased prepulse inhibition 9 | 82
increased circulating choleste... 9 | 66
increased heart weight 9 | 62
increased hematocrit 9 | 46
increased mean corpuscular hem... 9 | 96
increased monocyte cell number 9 | 63
abnormal coat-hair pigmentatio... 8 | 64
decreased caudal vertebrae num... 8 | 53
decreased circulating serum al... 8 | 82
decreased red blood cell distr... 8 | 41
increased circulating alkaline... 8 | 122
abnormal gait 7 | 69
abnormal retina morphology 7 | 71
abnormal retinal blood vessel ... 7 | 26
abnormal testis morphology 7 | 43
decreased circulating HDL chol... 7 | 68
decreased circulating total pr... 7 | 49
decreased fasted circulating g... 7 | 65
decreased startle reflex 7 | 75
increased erythrocyte cell num... 7 | 39
increased mean platelet volume 7 | 45
increased or absent threshold ... 7 | 101
abnormal eye morphology 6 | 68
abnormal skin morphology 6 | 50
abnormal sleep behavior 6 | 70
decreased blood urea nitrogen ... 6 | 51
decreased circulating alanine ... 6 | 47
decreased circulating alkaline... 6 | 46
decreased circulating calcium ... 6 | 36
decreased leukocyte cell numbe... 6 | 73
decreased mean corpuscular hem... 6 | 50
decreased mean corpuscular vol... 6 | 79
enlarged spleen 6 | 41
female infertility 6 | 60
hemorrhage 6 | 23
hydrometra 6 | 53
improved glucose tolerance 6 | 79
increased body length 6 | 32
increased circulating iron lev... 6 | 30
increased circulating triglyce... 6 | 42
limb grasping 6 | 41
thrombocytosis 6 | 27
abnormal vibrissa morphology 5 | 25
corneal opacity 5 | 32
decreased circulating LDL chol... 5 | 38
decreased circulating amylase ... 5 | 28
decreased hematocrit 5 | 46
decreased hemoglobin content 5 | 68
decreased neutrophil cell numb... 5 | 42
impaired pupillary reflex 5 | 26
increased body weight 5 | 25
increased hemoglobin content 5 | 45
pallor 5 | 34

Disease

Carcinoma 1,615 | 11,493
osteosarcoma 1,127 | 7,950
ovarian cancer 1,067 | 8,520
medulloblastoma, large-cell 779 | 6,241
glioblastoma 702 | 5,792
psoriasis 699 | 6,694
atypical teratoid / rhabdoid tumor 623 | 5,112
group 3 medulloblastoma 566 | 4,104
lung cancer 556 | 4,740
ependymoma 539 | 4,679
adult high grade glioma 439 | 3,801
primitive neuroectodermal tumor 435 | 3,035
Breast cancer 415 | 3,578
Kidney cancer 407 | 2,613
malignant mesothelioma 394 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 381 | 3,291
oligodendroglioma 358 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 355 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 342 | 2,989
Astrocytoma, Pilocytic 339 | 3,081
astrocytic glioma 324 | 2,597
invasive ductal carcinoma 317 | 2,951
lung carcinoma 299 | 2,843
non-small cell lung cancer 287 | 2,890
group 4 medulloblastoma 281 | 1,855
Cancer 277 | 2,499
pancreatic cancer 275 | 2,398
lung adenocarcinoma 273 | 2,716
subependymal giant cell astrocytoma 269 | 2,287
Pick disease 255 | 1,894
tuberculosis 250 | 2,010
interstitial cystitis 227 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 227 | 1,962
pituitary cancer 216 | 1,972
ulcerative colitis 197 | 1,819
cystic fibrosis 187 | 1,696
ductal carcinoma in situ 180 | 1,745
Autosomal recessive predisposition 178 | 1,442
breast carcinoma 178 | 1,638
adrenocortical carcinoma 175 | 1,428
colon cancer 156 | 1,478
juvenile dermatomyositis 156 | 1,187
acute quadriplegic myopathy 148 | 1,158
spina bifida 146 | 1,074
Rheumatoid arthritis 142 | 1,191
astrocytoma 142 | 1,146
Intellectual disability 141 | 1,016
pediatric high grade glioma 139 | 1,064
Multiple myeloma 138 | 1,332
Schizophrenia 126 | 1,160
diabetes mellitus 126 | 1,728
primary pancreatic ductal adenocarcinoma 118 | 1,109
non primary Sjogren syndrome sicca 115 | 891
dermatomyositis 112 | 966
cutaneous lupus erythematosus 104 | 1,057
nasopharyngeal carcinoma 104 | 1,058
active Crohn's disease 103 | 922
acute myeloid leukemia 103 | 783
progressive supranuclear palsy 99 | 676
Atopic dermatitis 96 | 952
Epilepsy 95 | 792
Dull intelligence 94 | 645
Low intelligence 94 | 645
Mental Retardation 94 | 645
Mental deficiency 94 | 645
Poor school performance 94 | 645
medulloblastoma 92 | 720
gastric carcinoma 90 | 807
primary Sjogren syndrome 89 | 735
Cognitive delay 87 | 608
Global developmental delay 87 | 608
Liver cancer 87 | 604
Mental and motor retardation 87 | 608
aldosterone-producing adenoma 87 | 665
Short stature 82 | 531
Seizures 80 | 596
active ulcerative colitis 79 | 764
Liver Cirrhosis, Experimental 78 | 769
Bipolar Disorder 77 | 666
Melanoma 77 | 711
esophageal adenocarcinoma 74 | 737
Muscle hypotonia 73 | 571
Waldenstrons macroglobulinemia 73 | 765
Obesity 72 | 678
hepatocellular carcinoma 72 | 547
Alzheimer's disease 71 | 658
Amyotrophic lateral sclerosis 71 | 451
gastric cancer 71 | 459
pancreatic carcinoma 65 | 562
Duchenne muscular dystrophy 62 | 601
posterior fossa group A ependymoma 58 | 468
chronic rhinosinusitis 57 | 512
tuberculosis and treatment for 6 months 57 | 409
Down syndrome 56 | 499
Endometriosis 54 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 54 | 510
fibroadenoma 54 | 559
Prostatic Neoplasms 53 | 495
Breast Neoplasms 52 | 445
Skin cancer 52 | 469

Tissue

Endocrine System 2,192 | 18,159
Digestive Tract 2,137 | 17,369
Female tissues 2,135 | 17,400
Skin and soft tissues 2,132 | 17,230
Male tissues 2,124 | 17,142
Blood and immune system 2,117 | 16,909
Liver and Pancreas 2,106 | 16,750
Nervous System 2,105 | 16,725
Urinary Tract 2,091 | 16,678
Respiratory system 2,080 | 16,393
Cardiovascular System 1,987 | 15,192

Target Family

Enzyme 677 | 4,145
Transcription Factor 664 | 1,400
Non-IDG 633 | 12,091
Kinase 117 | 634
Epigenetic 90 | 242
Transporter 27 | 473
Ion Channel 26 | 344
TF/Epigenetic 19 | 38
GPCR 3 | 408

GO Function

metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
Zinc finger protein 160 ZNF160 Tdark Transcription Factor -0.67261 4.33 63
Zinc finger protein 316 ZNF316 Tdark Non-IDG 0.00000 8
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4 AGAP4 Tdark Enzyme 0.23 0.50 66
Zinc finger protein 99 ZNF99 Tdark Transcription Factor 1.38 0.03 50
CAP-Gly domain-containing linker protein 1 CLIP1 Tbio Non-IDG -2.54943 343.7 221
Protein pelota homolog PELO Tbio Non-IDG -1.33842 18.2 100
Peroxisome biogenesis factor 2 PEX2 Tbio Non-IDG -1.76849 57.3 170
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 Tclin Enzyme -1.42734 26.2 214
LIM domain only protein 7 LMO7 Tbio Non-IDG -1.24771 19.7 80