Development Level

Tbio 32 | 11,445
Tchem 15 | 1,598
Tdark 4 | 6,588
Tclin 2 | 613

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal kidney morphology 2 | 65
abnormal retina morphology 2 | 71
abnormal seminal vesicle morph... 2 | 114
embryonic lethality prior to o... 2 | 239
preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal cranium morphology 1 | 36
abnormal heart morphology 1 | 162
abnormal vibrissa morphology 1 | 25
abnormal vitreous body morphol... 1 | 10
decreased blood urea nitrogen ... 1 | 51
decreased circulating calcium ... 1 | 36
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
hydrometra 1 | 53
increased CD4-positive, CD25-p... 1 | 1
increased KLRG1-positive NK ce... 1 | 1
increased NK cell number 1 | 3
increased anti-nuclear antigen... 1 | 19
increased circulating total pr... 1 | 28
increased effector memory CD4-... 1 | 1
increased erythrocyte cell num... 1 | 39
increased heart weight 1 | 62
increased monocyte cell number 1 | 63
limb grasping 1 | 41
male infertility 1 | 123
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small superior vagus ganglion 1 | 74
tremors 1 | 39

Disease

Carcinoma 41 | 11,493
ovarian cancer 32 | 8,520
osteosarcoma 26 | 7,950
glioblastoma 22 | 5,792
lung cancer 20 | 4,740
psoriasis 20 | 6,694
medulloblastoma, large-cell 19 | 6,241
ependymoma 17 | 4,679
atypical teratoid / rhabdoid tumor 15 | 5,112
group 3 medulloblastoma 15 | 4,104
adult high grade glioma 14 | 3,801
Autosomal recessive predisposition 12 | 1,442
primitive neuroectodermal tumor 12 | 3,035
Breast cancer 11 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
malignant mesothelioma 10 | 3,232
Kidney cancer 9 | 2,613
Rheumatoid arthritis 9 | 1,191
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
Cancer 8 | 2,499
Multiple myeloma 8 | 1,332
astrocytic glioma 8 | 2,597
dermatomyositis 8 | 966
oligodendroglioma 8 | 2,850
Astrocytoma, Pilocytic 7 | 3,081
Cognitive delay 7 | 608
Global developmental delay 7 | 608
Mental and motor retardation 7 | 608
Pick disease 7 | 1,894
Seizures 7 | 596
colon cancer 7 | 1,478
cystic fibrosis 7 | 1,696
diabetes mellitus 7 | 1,728
juvenile dermatomyositis 7 | 1,187
lung adenocarcinoma 7 | 2,716
lung carcinoma 7 | 2,843
non-small cell lung cancer 7 | 2,890
spina bifida 7 | 1,074
tuberculosis 7 | 2,010
ulcerative colitis 7 | 1,819
Bipolar Disorder 6 | 666
Osteoporosis 6 | 363
Waldenstrons macroglobulinemia 6 | 765
active Crohn's disease 6 | 922
astrocytoma 6 | 1,146
group 4 medulloblastoma 6 | 1,855
sarcoidosis 6 | 370
Atopic dermatitis 5 | 952
Epilepsy 5 | 792
Intellectual disability 5 | 1,016
Muscle hypotonia 5 | 571
Obesity 5 | 678
acute quadriplegic myopathy 5 | 1,158
cutaneous lupus erythematosus 5 | 1,057
ductal carcinoma in situ 5 | 1,745
interstitial cystitis 5 | 2,312
invasive ductal carcinoma 5 | 2,951
pancreatic cancer 5 | 2,398
Acquired metabolic disease 4 | 336
Asthma 4 | 385
Carcinoma, Hepatocellular 4 | 228
Fever 4 | 138
Liver carcinoma 4 | 240
Neurodegenerative disease 4 | 414
Precancerous Conditions 4 | 80
Short stature 4 | 531
active ulcerative colitis 4 | 764
breast carcinoma 4 | 1,638
chronic rhinosinusitis 4 | 512
pituitary cancer 4 | 1,972
primary Sjogren syndrome 4 | 735
sonic hedgehog group medulloblastoma 4 | 467
subependymal giant cell astrocytoma 4 | 2,287
Babinski Reflex 3 | 100
Chronic obstructive pulmonary disease 3 | 184
Concave bridge of nose 3 | 195
Crohn's disease 3 | 321
Depressed nasal bridge 3 | 195
Depressed nasal root/bridge 3 | 195
Depressive disorder 3 | 409
Diabetes Mellitus, Non-Insulin-Dependent 3 | 145
Down syndrome 3 | 499
Electroencephalogram abnormal 3 | 101
Hypoglycemia 3 | 152
Liver neoplasms 3 | 130
Multiple Sclerosis 3 | 540
Myopathy 3 | 185
Neurogenic Muscular Atrophy 3 | 139
Prostatic Neoplasms 3 | 495
Schizophrenia 3 | 1,160
Thin skin 3 | 47
Vascular disease 3 | 319
esophageal adenocarcinoma 3 | 737
hereditary spastic paraplegia 3 | 318
muscle degeneration 3 | 139
nasopharyngeal carcinoma 3 | 1,058
pancreatic carcinoma 3 | 562
progressive supranuclear palsy 3 | 676

Tissue

Endocrine System 52 | 18,159
Blood and immune system 51 | 16,909
Female tissues 51 | 17,400
Liver and Pancreas 51 | 16,750
Skin and soft tissues 51 | 17,230
Urinary Tract 51 | 16,678
Cardiovascular System 50 | 15,192
Male tissues 50 | 17,142
Nervous System 50 | 16,725
Digestive Tract 49 | 17,369
Respiratory system 49 | 16,393

Target Family

Enzyme 40 | 4,145
Kinase 7 | 634
Non-IDG 3 | 12,091
Transporter 3 | 473

GO Function

manganese ion binding 53 | 53
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beta-1,4-galactosyltransferase 1 B4GALT1 Tbio Enzyme -2.34454 211.1 130
Adenylate cyclase type 10 ADCY10 Tchem Enzyme -3.13751 1324.4 108
Sodium/potassium/calcium exchanger 2 SLC24A2 Tbio Transporter -1.39605 25.7 32
Abelson tyrosine-protein kinase 2 ABL2 Tchem Kinase -1.86293 71.2 358
Histo-blood group ABO system transferase ABO Tbio Enzyme 0.00000 0
Probable aminopeptidase NPEPL1 NPEPL1 Tdark Enzyme 0.12 0.49 52
NADP-dependent malic enzyme ME1 Tchem Non-IDG -1.98857 92.8 234
Cytosol aminopeptidase LAP3 Tchem Enzyme -2.59176 385.7 172
Poly(A) RNA polymerase, mitochondrial MTPAP Tbio Enzyme -1.36829 24.0 68
Serine/threonine-protein kinase Nek4 NEK4 Tbio Kinase -1.15584 11.5 142