Development Level

Tbio 112 | 11,651
Tchem 63 | 1,388
Tdark 15 | 6,593
Tclin 7 | 612

Collection

Kinase: IDG Consortium (Target... 20 | 125
RFA-RM-18-021 20 | 328
Kinase: IDG Consortium (Comple... 7 | 37

IMPC Phenotype

preweaning lethality, complete... 14 | 979
preweaning lethality, incomple... 6 | 499
enlarged heart 5 | 210
abnormal heart morphology 4 | 162
embryonic lethality prior to t... 4 | 278
abnormal behavior 3 | 298
abnormal retina morphology 3 | 71
decreased mean corpuscular vol... 3 | 79
embryonic lethality prior to o... 3 | 239
abnormal behavioral response t... 2 | 66
abnormal embryo size 2 | 220
decreased circulating glucose ... 2 | 126
decreased erythrocyte cell num... 2 | 62
decreased lean body mass 2 | 135
decreased total body fat amoun... 2 | 207
hyperactivity 2 | 148
increased erythrocyte cell num... 2 | 39
increased heart weight 2 | 62
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 36
increased monocyte cell number 2 | 63
limb grasping 2 | 41
small superior vagus ganglion 2 | 74
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal ear morphology 1 | 9
abnormal eye morphology 1 | 68
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal pancreas morphology 1 | 13
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal vibrissa morphology 1 | 25
absent startle reflex 1 | 24
anophthalmia 1 | 33
brachydactyly 1 | 19
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating fructosa... 1 | 30
decreased circulating serum al... 1 | 82
decreased fasted circulating g... 1 | 65
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean platelet volume 1 | 25
decreased prepulse inhibition 1 | 82
decreased pulmonary respirator... 1 | 5
decreased startle reflex 1 | 75
decreased total retina thickne... 1 | 17
decreased vertical activity 1 | 208
edema 1 | 59
enlarged uterus 1 | 11
hydrometra 1 | 53
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased anti-nuclear antigen... 1 | 19
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating sodium l... 1 | 71
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
increased prepulse inhibition 1 | 32
long tibia 1 | 25
microphthalmia 1 | 26
pale yolk sac 1 | 25
pallor 1 | 34
polycystic kidney 1 | 15
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small adrenal glands 1 | 16
syndactyly 1 | 23
thrombocytopenia 1 | 56
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Carcinoma 143 | 11,493
ovarian cancer 113 | 8,520
osteosarcoma 107 | 7,950
medulloblastoma, large-cell 86 | 6,241
psoriasis 86 | 6,694
glioblastoma 75 | 5,792
atypical teratoid / rhabdoid tumor 69 | 5,112
lung cancer 65 | 4,740
ependymoma 56 | 4,679
adult high grade glioma 55 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 52 | 3,291
Breast cancer 50 | 3,578
group 3 medulloblastoma 49 | 4,104
Kidney cancer 45 | 2,613
malignant mesothelioma 44 | 3,232
non-small cell lung cancer 43 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 41 | 2,989
Astrocytoma, Pilocytic 39 | 3,081
invasive ductal carcinoma 39 | 2,951
lung adenocarcinoma 39 | 2,716
lung carcinoma 38 | 2,843
primitive neuroectodermal tumor 38 | 3,035
Cancer 36 | 2,499
intraductal papillary-mucinous adenoma (IPMA) 36 | 2,955
pancreatic cancer 35 | 2,398
oligodendroglioma 30 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 30 | 1,962
group 4 medulloblastoma 29 | 1,855
astrocytic glioma 28 | 2,597
tuberculosis 28 | 2,010
adrenocortical carcinoma 27 | 1,428
Multiple myeloma 26 | 1,332
Pick disease 26 | 1,894
colon cancer 26 | 1,478
pituitary cancer 26 | 1,972
ductal carcinoma in situ 25 | 1,745
interstitial cystitis 25 | 2,312
breast carcinoma 24 | 1,638
ulcerative colitis 24 | 1,819
Autosomal recessive predisposition 23 | 1,442
subependymal giant cell astrocytoma 23 | 2,287
diabetes mellitus 21 | 1,728
Waldenstrons macroglobulinemia 20 | 765
active Crohn's disease 19 | 922
cystic fibrosis 18 | 1,696
Rheumatoid arthritis 17 | 1,191
Schizophrenia 17 | 1,160
primary pancreatic ductal adenocarcinoma 16 | 1,109
Epilepsy 15 | 792
dermatomyositis 15 | 966
juvenile dermatomyositis 15 | 1,187
Intellectual disability 14 | 1,016
nasopharyngeal carcinoma 14 | 1,058
non primary Sjogren syndrome sicca 14 | 891
spina bifida 14 | 1,074
Seizures 13 | 596
gastric carcinoma 13 | 807
Muscle hypotonia 12 | 571
active ulcerative colitis 12 | 764
acute quadriplegic myopathy 12 | 1,158
astrocytoma 12 | 1,146
chronic rhinosinusitis 12 | 512
cutaneous lupus erythematosus 12 | 1,057
Dull intelligence 11 | 645
Low intelligence 11 | 645
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Poor school performance 11 | 645
Short stature 11 | 531
Alzheimer's disease 10 | 658
Liver Cirrhosis, Experimental 10 | 769
Neurodegenerative disease 10 | 414
Osteoporosis 10 | 363
medulloblastoma 10 | 720
pediatric high grade glioma 10 | 1,064
Asthma 9 | 385
Carcinoma, Hepatocellular 9 | 228
Cerebellar Ataxia 9 | 304
Cognitive delay 9 | 608
Global developmental delay 9 | 608
Liver cancer 9 | 604
Liver carcinoma 9 | 240
Mental and motor retardation 9 | 608
acute myeloid leukemia 9 | 783
esophageal adenocarcinoma 9 | 737
pancreatic carcinoma 9 | 562
sonic hedgehog group medulloblastoma 9 | 467
Anemia 8 | 365
Atopic dermatitis 8 | 952
Bipolar Disorder 8 | 666
Melanoma 8 | 711
aldosterone-producing adenoma 8 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 510
hepatocellular carcinoma 8 | 547
Down syndrome 7 | 499
Hypertension 7 | 396
Hypertensive disease 7 | 292
Optic Atrophy 7 | 242
Parkinson's disease 7 | 392
Vascular disease 7 | 319

Tissue

Endocrine System 196 | 18,159
Digestive Tract 193 | 17,369
Skin and soft tissues 193 | 17,230
Blood and immune system 192 | 16,909
Female tissues 192 | 17,400
Liver and Pancreas 191 | 16,750
Urinary Tract 191 | 16,678
Male tissues 190 | 17,142
Nervous System 190 | 16,725
Respiratory system 186 | 16,393
Cardiovascular System 179 | 15,192

Target Family

Enzyme 87 | 4,145
Kinase 77 | 634
Non-IDG 16 | 12,091
Transporter 15 | 473
GPCR 1 | 408
Transcription Factor 1 | 1,400

GO Function

magnesium ion binding 197 | 197
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Alkaline phosphatase, placental type ALPP Tbio Enzyme -2.71952 511.2 929
Diphosphoinositol polyphosphate phosphohydrolase 1 NUDT3 Tbio Enzyme -2.01736 105.3 40
ADP-sugar pyrophosphatase NUDT5 Tbio Enzyme -1.49012 32.8 61
Phosphatidylinositol 4-kinase type 2-alpha PI4K2A Tbio Kinase -2.88003 745.1 146
Interleukin-1 receptor-associated kinase 4 IRAK4 Tchem Kinase -2.28820 202.2 610
Interleukin-1 receptor-associated kinase 3 IRAK3 Tchem Kinase -1.86631 84.0 427
Thiamine-triphosphatase THTPA Tbio Enzyme -1.53297 36.7 119
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.09531 11.7 331
SRSF protein kinase 1 SRPK1 Tchem Kinase -1.86831 75.3 351
Guanine nucleotide-binding protein G(i) subunit alpha-1 GNAI1 Tbio Non-IDG -0.63224 3.23 220