Development Level

Tbio 102 | 10,625
Tchem 72 | 1,890
Tdark 18 | 7,003
Tclin 5 | 602

Collection

Eligible Kinase Proteins 21 | 134

IMPC Term

preweaning lethality, complete... 7 | 633
decreased lean body mass 5 | 195
abnormal retina morphology 3 | 100
abnormal retinal pigmentation 3 | 61
decreased circulating serum al... 3 | 79
decreased total body fat amoun... 3 | 186
increased bone mineral content 3 | 92
abnormal behavioral response t... 2 | 52
decreased body length 2 | 108
decreased circulating glucose ... 2 | 121
embryonic lethality prior to t... 2 | 187
increased body weight 2 | 42
increased circulating bilirubi... 2 | 16
increased circulating sodium l... 2 | 71
increased erythrocyte cell num... 2 | 26
increased heart weight 2 | 37
increased lean body mass 2 | 107
increased mature B cell number 2 | 12
increased rib number 2 | 41
limb grasping 2 | 35
preweaning lethality, incomple... 2 | 260
abnormal behavior 1 | 226
abnormal bone structure 1 | 131
abnormal cornea morphology 1 | 24
abnormal ear morphology 1 | 5
abnormal embryo size 1 | 112
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal gait 1 | 51
abnormal heart left ventricle ... 1 | 20
abnormal heart morphology 1 | 51
abnormal lens morphology 1 | 73
abnormal skin appearance 1 | 8
abnormal sleep behavior 1 | 63
abnormal spleen morphology 1 | 36
abnormal vitreous body morphol... 1 | 7
absent startle reflex 1 | 15
absent vibrissae 1 | 14
anophthalmia 1 | 20
craniofacial phenotype 1 | 9
decreased blood urea nitrogen ... 1 | 31
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased circulating HDL chol... 1 | 77
decreased circulating creatini... 1 | 31
decreased circulating fructosa... 1 | 31
decreased erythrocyte cell num... 1 | 43
decreased fasted circulating g... 1 | 49
decreased gamma-delta T cell n... 1 | 18
decreased heart weight 1 | 44
decreased hemoglobin content 1 | 53
decreased prepulse inhibition 1 | 52
decreased pulmonary respirator... 1 | 4
decreased rib number 1 | 59
decreased startle reflex 1 | 48
embryonic lethality prior to o... 1 | 148
enlarged heart 1 | 111
herniated abdominal wall 1 | 4
hydrops fetalis 1 | 22
hyperactivity 1 | 108
impaired glucose tolerance 1 | 52
improved glucose tolerance 1 | 56
increased B cell number 1 | 23
increased CD4-positive, CD25-p... 1 | 18
increased KLRG1-positive NK ce... 1 | 9
increased NK T cell number 1 | 11
increased T cell number 1 | 15
increased blood urea nitrogen ... 1 | 44
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating alkaline... 1 | 119
increased circulating choleste... 1 | 53
increased eosinophil cell numb... 1 | 9
increased gamma-delta T cell n... 1 | 16
increased grip strength 1 | 83
increased heart rate variabili... 1 | 4
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
increased memory CD4-positive,... 1 | 3
increased or absent threshold ... 1 | 128
increased total body fat amoun... 1 | 57
microphthalmia 1 | 15
pale yolk sac 1 | 12
polycystic kidney 1 | 9
prenatal lethality prior to he... 1 | 64
short tibia 1 | 82
small adrenal glands 1 | 15
small superior vagus ganglion 1 | 20
straub tail 1 | 26
thrombocytopenia 1 | 46
trunk curl 1 | 15

Disease

ovarian cancer 116 | 8,484
osteosarcoma 107 | 7,933
psoriasis 86 | 6,685
medulloblastoma, large-cell 84 | 6,234
glioblastoma 71 | 5,572
lung cancer 62 | 4,466
atypical teratoid / rhabdoid tumor 56 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 56 | 3,289
Breast cancer 49 | 3,094
malignant mesothelioma 45 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 43 | 2,988
non-small cell lung cancer 43 | 2,798
intraductal papillary-mucinous adenoma (IPMA) 39 | 2,956
lung adenocarcinoma 39 | 2,713
invasive ductal carcinoma 38 | 2,950
lung carcinoma 36 | 2,844
pediatric high grade glioma 36 | 2,712
Carcinoma 35 | 2,147
pilocytic astrocytoma 35 | 3,086
primitive neuroectodermal tumor 35 | 3,031
ependymoma 34 | 2,514
pancreatic cancer 33 | 2,300
Cancer 32 | 2,346
oligodendroglioma 31 | 2,849
ulcerative colitis 31 | 2,087
pancreatic ductal adenocarcinoma liver metastasis 30 | 1,795
adult high grade glioma 28 | 2,148
colon cancer 27 | 1,475
ductal carcinoma in situ 27 | 1,745
pituitary cancer 27 | 1,972
adrenocortical carcinoma 26 | 1,427
group 3 medulloblastoma 26 | 2,254
group 4 medulloblastoma 26 | 1,875
sonic hedgehog group medulloblastoma 26 | 1,482
tuberculosis 26 | 1,557
Multiple myeloma 25 | 1,327
interstitial cystitis 25 | 2,299
Pick disease 24 | 1,893
subependymal giant cell astrocytoma 23 | 2,287
astrocytic glioma 22 | 2,241
breast carcinoma 20 | 1,614
Waldenstrons macroglobulinemia 19 | 765
astrocytoma 18 | 1,493
cystic fibrosis 18 | 1,665
diabetes mellitus 18 | 1,663
posterior fossa group B ependymoma 18 | 1,530
primary pancreatic ductal adenocarcinoma 18 | 1,271
Rheumatoid Arthritis 17 | 1,160
active Crohn's disease 17 | 918
juvenile dermatomyositis 16 | 1,189
medulloblastoma 15 | 1,524
spina bifida 15 | 1,064
atypical teratoid/rhabdoid tumor 14 | 1,095
dermatomyositis 14 | 933
nasopharyngeal carcinoma 14 | 1,056
posterior fossa group A ependymoma 14 | 1,511
acute quadriplegic myopathy 13 | 1,157
gastric carcinoma 13 | 832
non primary Sjogren syndrome sicca 13 | 840
chronic rhinosinusitis 12 | 512
cutaneous lupus erythematosus 12 | 1,056
esophageal adenocarcinoma 10 | 737
pancreatic carcinoma 10 | 567
Alzheimer's disease 9 | 644
Atopic dermatitis 9 | 944
Bipolar Disorder 9 | 266
Neurodegenerative disease 9 | 383
aldosterone-producing adenoma 9 | 664
tuberculosis and treatment for 6 months 9 | 686
Asthma 8 | 349
IGA Glomerulonephritis 8 | 454
Liver carcinoma 8 | 217
acute myeloid leukemia 8 | 780
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 499
hepatocellular carcinoma 8 | 532
Autistic Disorder 7 | 320
Down syndrome 7 | 548
Endometriosis 7 | 535
Intellectual disability 7 | 573
Osteoporosis 7 | 257
Parkinson's disease 7 | 364
active ulcerative colitis 7 | 477
non-small cell lung carcinoma 7 | 413
sarcoidosis 7 | 358
Chronic Myelocytic Leukemia Accelerated Phase 6 | 59
Chronic phase chronic myeloid leukemia 6 | 45
Crohn's disease 6 | 304
Gastrointestinal stromal tumor 6 | 61
Mammary Neoplasms 6 | 410
Neoplasm Invasiveness 6 | 127
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 6 | 45
Prostatic Neoplasms 6 | 471
Renal Cell Carcinoma 6 | 199
Toxic encephalopathy 6 | 131
Vascular disease 6 | 281
tuberculosis and treatment for 3 months 6 | 327
Duchenne muscular dystrophy 5 | 602
Schizophrenia 5 | 501
primary Sjogren syndrome 5 | 789
urothelial carcinoma 5 | 318

Tissue

Endocrine System 196 | 18,512
Digestive Tract 195 | 18,473
Male tissues 195 | 17,969
Nervous System 195 | 18,561
Blood and immune system 194 | 17,995
Female tissues 194 | 18,647
Liver and Pancreas 194 | 18,136
Urinary Tract 194 | 18,444
Skin and soft tissues 192 | 18,115
Cardiovascular System 191 | 17,958
Respiratory system 191 | 17,484

Target Family

Enzyme 91 | 4,146
Kinase 75 | 634
Non-IDG 15 | 11,971
Transporter 15 | 473
Transcription Factor 1 | 1,400

GO Function

magnesium ion binding 197 | 197
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable phospholipid-transporting ATPase IIB ATP9B Tdark Transporter -0.57248 3.74 5
Pyruvate kinase PKM PKM Tchem Kinase -3.09101 1313.5 672
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B Tbio Enzyme -1.13428 13.6 146
Inositol polyphosphate 1-phosphatase INPP1 Tbio Enzyme -1.22269 17.2 73
Mitogen-activated protein kinase kinase kinase MLT MAP3K20 Tchem Kinase -1.14470 13.6 205
[Protein ADP-ribosylarginine] hydrolase-like protein 1 ADPRHL1 Tdark Enzyme 0.37 0.83 31
Alpha-synuclein SNCA Tchem Non-IDG -3.59982 3997.3 1484
DNA topoisomerase 2-alpha TOP2A Tclin Enzyme -2.81595 662.3 551
Glutathione synthetase GSS Tbio Enzyme -2.75264 568.9 200
Pseudouridine-5'-phosphatase PUDP Tdark Enzyme 0.30 0.93 73