Development Level

Tbio 55 | 11,445
Tchem 2 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 4 | 979
embryonic lethality prior to o... 3 | 239
increased lymphocyte cell numb... 2 | 32
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal retina morphology 1 | 71
absent startle reflex 1 | 24
decreased IgE level 1 | 6
decreased basophil cell number 1 | 16
decreased blood urea nitrogen ... 1 | 51
decreased caudal vertebrae num... 1 | 53
decreased circulating phosphat... 1 | 27
decreased circulating triglyce... 1 | 79
decreased heart weight 1 | 27
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased startle reflex 1 | 75
decreased threshold for audito... 1 | 26
embryonic lethality prior to t... 1 | 278
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased NK cell number 1 | 3
increased fasted circulating g... 1 | 76
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
prenatal lethality prior to he... 1 | 87

Disease

Carcinoma 41 | 11,493
ovarian cancer 34 | 8,520
medulloblastoma, large-cell 25 | 6,241
osteosarcoma 25 | 7,950
group 3 medulloblastoma 24 | 4,104
atypical teratoid / rhabdoid tumor 21 | 5,112
glioblastoma 21 | 5,792
lung cancer 20 | 4,740
ependymoma 18 | 4,679
psoriasis 16 | 6,694
Breast cancer 14 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
adult high grade glioma 13 | 3,801
oligodendroglioma 12 | 2,850
Astrocytoma, Pilocytic 11 | 3,081
astrocytic glioma 11 | 2,597
diabetes mellitus 11 | 1,728
Multiple myeloma 10 | 1,332
Pick disease 10 | 1,894
primitive neuroectodermal tumor 10 | 3,035
acute quadriplegic myopathy 9 | 1,158
lung adenocarcinoma 9 | 2,716
malignant mesothelioma 9 | 3,232
Amyotrophic lateral sclerosis 8 | 451
non-small cell lung cancer 8 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
spina bifida 8 | 1,074
subependymal giant cell astrocytoma 8 | 2,287
Cancer 7 | 2,499
Waldenstrons macroglobulinemia 7 | 765
astrocytoma 7 | 1,146
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
juvenile dermatomyositis 7 | 1,187
pancreatic cancer 7 | 2,398
Infertility 6 | 188
Rheumatoid arthritis 6 | 1,191
Schizophrenia 6 | 1,160
acute myeloid leukemia 6 | 783
cystic fibrosis 6 | 1,696
dermatomyositis 6 | 966
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
invasive ductal carcinoma 6 | 2,951
lung carcinoma 6 | 2,843
pediatric high grade glioma 6 | 1,064
tuberculosis 6 | 2,010
Azoospermia 5 | 110
Breast Neoplasms 5 | 445
Kidney cancer 5 | 2,613
Mammary Neoplasms 5 | 425
adrenocortical carcinoma 5 | 1,428
nasopharyngeal carcinoma 5 | 1,058
progressive supranuclear palsy 5 | 676
Autosomal recessive predisposition 4 | 1,442
Cryptorchidism 4 | 296
Intellectual disability 4 | 1,016
Oligospermia 4 | 36
Partial chromosome Y deletion 4 | 7
Premature ovarian failure 4 | 65
Sertoli cell-only syndrome 4 | 37
group 4 medulloblastoma 4 | 1,855
mucosa-associated lymphoid tissue lymphoma 4 | 484
pituitary cancer 4 | 1,972
primary pancreatic ductal adenocarcinoma 4 | 1,109
relapsing-remitting multiple sclerosis 4 | 18
Anemia 3 | 365
Atopic dermatitis 3 | 952
Cerebral atrophy 3 | 178
Chronic Lymphocytic Leukemia 3 | 262
Cognitive delay 3 | 608
Down syndrome 3 | 499
Dysarthria 3 | 192
Endometriosis 3 | 540
Epilepsy 3 | 792
Failure to gain weight 3 | 365
Fatigue 3 | 182
Frontotemporal dementia 3 | 51
Global developmental delay 3 | 608
Infantile onset 3 | 238
Klinefelter's syndrome 3 | 56
Male infertility 3 | 206
Mental and motor retardation 3 | 608
Mood Disorders 3 | 184
Neurodegenerative disease 3 | 414
Pediatric failure to thrive 3 | 365
Spermatogenic Failure, Nonobstructive, Y-Linked 3 | 15
breast carcinoma 3 | 1,638
ductal carcinoma in situ 3 | 1,745
esophageal adenocarcinoma 3 | 737
gastric carcinoma 3 | 807
inflammatory breast cancer 3 | 286
interstitial cystitis 3 | 2,312
non primary Sjogren syndrome sicca 3 | 891
ulcerative colitis 3 | 1,819
Alzheimer's disease 2 | 658
Kidney disease 2 | 430
Polycystic ovary syndrome 2 | 360
Seizures 2 | 596
Type 2 diabetes mellitus 2 | 272
active Crohn's disease 2 | 922
substance-related disorder 2 | 162

Tissue

Endocrine System 58 | 18,159
Digestive Tract 56 | 17,369
Skin and soft tissues 55 | 17,230
Blood and immune system 53 | 16,909
Female tissues 53 | 17,400
Liver and Pancreas 53 | 16,750
Male tissues 52 | 17,142
Nervous System 52 | 16,725
Respiratory system 52 | 16,393
Urinary Tract 52 | 16,678
Cardiovascular System 50 | 15,192

Target Family

Non-IDG 45 | 12,091
Enzyme 8 | 4,145
Transcription Factor 4 | 1,400
Epigenetic 1 | 242

GO Function

mRNA 3'-UTR binding 58 | 58
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable ATP-dependent RNA helicase DDX5 DDX5 Tbio Enzyme -2.08566 121.1 344
Insulin-like growth factor 2 mRNA-binding protein 2 IGF2BP2 Tbio Non-IDG -1.77792 57.3 400
Zinc finger protein 385A ZNF385A Tbio Non-IDG -0.03141 1.24 99
rRNA-processing protein UTP23 homolog UTP23 Tbio Non-IDG -0.52827 3.11 48
Calcium-regulated heat-stable protein 1 CARHSP1 Tbio Transcription Factor -0.46078 3.37 54
ELAV-like protein 4 ELAVL4 Tbio Non-IDG -2.53162 344.8 186
Heterogeneous nuclear ribonucleoprotein U HNRNPU Tbio Non-IDG -2.33813 207.8 169
Y-box-binding protein 3 YBX3 Tbio Transcription Factor -2.13168 143.1 204
Roquin-1 RC3H1 Tbio Non-IDG -1.59779 44.7 106
Cytoplasmic polyadenylation element-binding protein 3 CPEB3 Tbio Non-IDG -1.34679 21.2 88