Development Level

Tbio 7 | 10,625
Tdark 5 | 7,003
Tchem 3 | 1,890

IMPC Term

preweaning lethality, complete... 2 | 633
abnormal retina morphology 1 | 100
decreased CD4-positive, CD25-p... 1 | 24
decreased circulating alkaline... 1 | 41
decreased circulating aspartat... 1 | 27
decreased circulating creatini... 1 | 31
increased circulating aspartat... 1 | 17
increased mean corpuscular hem... 1 | 93

Disease

ovarian cancer 5 | 8,484
osteosarcoma 4 | 7,933
psoriasis 4 | 6,685
Cancer 3 | 2,346
glioblastoma 3 | 5,572
lung cancer 3 | 4,466
Breast cancer 2 | 3,094
Deglutition Disorders 2 | 4
Intellectual disability 2 | 573
Microcephaly 2 | 149
Movement Disorders 2 | 21
Neurodegenerative disease 2 | 383
Pontocerebellar Hypoplasia Type 2 2 | 4
Pontocerebellar hypoplasia 2 | 29
Vision Disorders 2 | 5
diabetes mellitus 2 | 1,663
group 3 medulloblastoma 2 | 2,254
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,289
malignant mesothelioma 2 | 3,162
pancreatic cancer 2 | 2,300
pancreatic carcinoma 2 | 567
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
pediatric high grade glioma 2 | 2,712
pituitary cancer 2 | 1,972
subependymal giant cell astrocytoma 2 | 2,287
Anhidrosis 1 | 12
Arthritis 1 | 248
Bladder Neoplasm 1 | 109
Bladder transitional cell papilloma 1 | 4
Chronic Lymphocytic Leukemia 1 | 242
Congenital Nonbullous Ichthyosiform Erythroderma 1 | 9
Congenital ichthyosiform erythroderma 1 | 27
Drug-Induced Liver Injury 1 | 118
Ectropion 1 | 18
Glycine encephalopathy 1 | 28
Histrionic personality disorder 1 | 3
ICHTHYOSIFORM ERYTHRODERMA, CONGENITAL, NONBULLOUS, 1 1 | 3
ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 3 1 | 1
ICHTHYOSIS, LAMELLAR, 5 1 | 1
Ichthyosis vulgaris 1 | 15
Inflammation 1 | 109
Lung disease 1 | 132
Lupus erythematosus 1 | 80
Myocardial Ischemia 1 | 169
Necrosis 1 | 51
Nonketotic Hyperglycinemia 1 | 3
Obesity 1 | 616
PHOSPHOHYDROXYLYSINURIA 1 | 1
Pain agnosia 1 | 99
Pancreatitis 1 | 97
Patent foramen ovale 1 | 9
Peripheral Neuropathy 1 | 303
Peritonitis 1 | 37
Pontocerebellar Hypoplasia Type 2B 1 | 1
Pontocerebellar Hypoplasia Type 2C 1 | 1
Prostate cancer 1 | 172
Prostatic Neoplasms 1 | 471
Rheumatoid Arthritis 1 | 1,160
Sepsis 1 | 21
Squamous cell carcinoma of esophagus 1 | 82
Systemic Vasculitis 1 | 1
Thyroid Neoplasm 1 | 33
Tinea corporis 1 | 25
Vascular disease 1 | 281
Weight Gain 1 | 87
Xanthinuria 1 | 8
Xanthinuria, Type II 1 | 1
active Crohn's disease 1 | 918
active ulcerative colitis 1 | 477
adrenocortical carcinoma 1 | 1,427
adult high grade glioma 1 | 2,148
alcohol-related neurodevelopmental disorder 1 | 11
astrocytoma 1 | 1,493
atypical teratoid / rhabdoid tumor 1 | 4,369
colon cancer 1 | 1,475
cystic fibrosis 1 | 1,665
ductal carcinoma in situ 1 | 1,745
gastric cancer 1 | 430
group 4 medulloblastoma 1 | 1,875
hepatocellular carcinoma 1 | 532
inflammatory breast cancer 1 | 404
interstitial cystitis 1 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 1 | 2,988
invasive ductal carcinoma 1 | 2,950
lung adenocarcinoma 1 | 2,713
non-small cell lung cancer 1 | 2,798
oligodendroglioma 1 | 2,849
pilocytic astrocytoma 1 | 3,086
primary pancreatic ductal adenocarcinoma 1 | 1,271
tuberculosis 1 | 1,557

Tissue

Blood and immune system 15 | 17,995
Cardiovascular System 15 | 17,958
Digestive Tract 15 | 18,473
Female tissues 15 | 18,647
Liver and Pancreas 15 | 18,136
Male tissues 15 | 17,969
Nervous System 15 | 18,561
Endocrine System 14 | 18,512
Urinary Tract 14 | 18,444
Respiratory system 13 | 17,484
Skin and soft tissues 13 | 18,115

Target Family

Enzyme 14 | 4,146
Transcription Factor 1 | 1,400

GO Function

lyase activity 15 | 15
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

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