Development Level

Tbio 87 | 11,651
Tdark 20 | 6,593
Tchem 15 | 1,388
Tclin 5 | 612

IMPC Phenotype

hypoactivity 5 | 132
decreased body weight 4 | 161
decreased vertical activity 3 | 208
enlarged heart 3 | 210
preweaning lethality, complete... 3 | 979
abnormal bone structure 2 | 187
abnormal eye size 2 | 7
decreased caudal vertebrae num... 2 | 53
decreased circulating glucose ... 2 | 126
decreased circulating serum al... 2 | 82
increased bone mineral density 2 | 72
increased circulating free fat... 2 | 20
increased lean body mass 2 | 172
increased total body fat amoun... 2 | 134
male infertility 2 | 123
abnormal QT variability 1 | 10
abnormal behavior 1 | 298
abnormal coat- hair morphology 1 | 19
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal liver morphology 1 | 17
abnormal retinal blood vessel ... 1 | 26
abnormal rib morphology 1 | 10
abnormal seminal vesicle morph... 1 | 114
abnormal skin coloration 1 | 25
abnormal tail morphology 1 | 25
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
abnormal vibrissa morphology 1 | 25
abnormal vitreous body morphol... 1 | 10
absent pinna reflex 1 | 23
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased prepulse inhibition 1 | 82
decreased threshold for audito... 1 | 26
decreased total body fat amoun... 1 | 207
female infertility 1 | 60
hydrometra 1 | 53
hyperactivity 1 | 148
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating fructosa... 1 | 13
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased hematocrit 1 | 46
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
persistence of hyaloid vascula... 1 | 33
preweaning lethality, incomple... 1 | 499
prolonged PR interval 1 | 15
prolonged QRS complex duration 1 | 8
prolonged QT interval 1 | 38
small superior vagus ganglion 1 | 74
vertebral fusion 1 | 23

Disease

Carcinoma 80 | 11,493
ovarian cancer 54 | 8,520
psoriasis 54 | 6,694
osteosarcoma 51 | 7,950
medulloblastoma, large-cell 40 | 6,241
glioblastoma 35 | 5,792
lung cancer 35 | 4,740
atypical teratoid / rhabdoid tumor 30 | 5,112
adult high grade glioma 29 | 3,801
ependymoma 28 | 4,679
lung adenocarcinoma 27 | 2,716
interstitial cystitis 24 | 2,312
diabetes mellitus 23 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 23 | 3,291
non-small cell lung cancer 23 | 2,890
group 3 medulloblastoma 22 | 4,104
lung carcinoma 22 | 2,843
oligodendroglioma 22 | 2,850
invasive ductal carcinoma 21 | 2,951
subependymal giant cell astrocytoma 21 | 2,287
Astrocytoma, Pilocytic 20 | 3,081
Breast cancer 20 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 20 | 2,955
pancreatic ductal adenocarcinoma liver metastasis 20 | 1,962
primitive neuroectodermal tumor 20 | 3,035
Cancer 19 | 2,499
astrocytic glioma 18 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,989
malignant mesothelioma 17 | 3,232
Kidney cancer 16 | 2,613
Obesity 14 | 678
ductal carcinoma in situ 14 | 1,745
group 4 medulloblastoma 14 | 1,855
Schizophrenia 13 | 1,160
adrenocortical carcinoma 13 | 1,428
ulcerative colitis 13 | 1,819
breast carcinoma 12 | 1,638
cutaneous lupus erythematosus 12 | 1,057
cystic fibrosis 12 | 1,696
tuberculosis 12 | 2,010
Pick disease 11 | 1,894
pancreatic cancer 11 | 2,398
Atherosclerosis 10 | 291
Autosomal recessive predisposition 10 | 1,442
Coronary artery disease 10 | 268
astrocytoma 10 | 1,146
pituitary cancer 10 | 1,972
Multiple myeloma 9 | 1,332
colon cancer 9 | 1,478
spina bifida 9 | 1,074
Atopic dermatitis 8 | 952
Down syndrome 8 | 499
Lipid metabolism disorder 8 | 114
esophageal adenocarcinoma 8 | 737
pediatric high grade glioma 8 | 1,064
Hypertension 7 | 396
active Crohn's disease 7 | 922
active ulcerative colitis 7 | 764
fibroadenoma 7 | 559
gastric carcinoma 7 | 807
nasopharyngeal carcinoma 7 | 1,058
primary Sjogren syndrome 7 | 735
Endometriosis 6 | 540
Hypertensive disease 6 | 292
Multiple Sclerosis 6 | 540
Muscle hypotonia 6 | 571
Prostatic Neoplasms 6 | 495
Waldenstrons macroglobulinemia 6 | 765
acute quadriplegic myopathy 6 | 1,158
dermatomyositis 6 | 966
non primary Sjogren syndrome sicca 6 | 891
posterior fossa group B ependymoma 6 | 416
Alzheimer's disease 5 | 658
Bipolar Disorder 5 | 666
Breast Neoplasms 5 | 445
Cardiovascular system disease 5 | 246
Chemical and Drug Induced Liver Injury 5 | 195
Hepatomegaly 5 | 285
Liver Cirrhosis, Experimental 5 | 769
Mammary Neoplasms 5 | 425
Melanoma 5 | 711
Parkinson's disease 5 | 392
Rheumatoid arthritis 5 | 1,191
Vascular disease 5 | 319
chronic rhinosinusitis 5 | 512
nephrosclerosis 5 | 333
primary pancreatic ductal adenocarcinoma 5 | 1,109
Cognitive delay 4 | 608
Death in early childhood 4 | 82
Global developmental delay 4 | 608
Kidney disease 4 | 430
Mental and motor retardation 4 | 608
Myopathy 4 | 185
Seizures 4 | 596
acute myeloid leukemia 4 | 783
atypical teratoid/rhabdoid tumor 4 | 357
juvenile dermatomyositis 4 | 1,187
mucosa-associated lymphoid tissue lymphoma 4 | 484
progressive supranuclear palsy 4 | 676
sonic hedgehog group medulloblastoma 4 | 467

Tissue

Endocrine System 123 | 18,159
Digestive Tract 119 | 17,369
Female tissues 118 | 17,400
Skin and soft tissues 118 | 17,230
Liver and Pancreas 114 | 16,750
Male tissues 114 | 17,142
Respiratory system 114 | 16,393
Blood and immune system 113 | 16,909
Nervous System 113 | 16,725
Urinary Tract 113 | 16,678
Cardiovascular System 100 | 15,192

Target Family

Non-IDG 100 | 12,091
Enzyme 14 | 4,145
GPCR 8 | 408
Kinase 3 | 634
Nuclear Receptor 2 | 48

GO Function

lipid binding 127 | 127
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sphingosine 1-phosphate receptor 4 S1PR4 Tclin GPCR -1.78966 58.4 256
Acyl-coenzyme A thioesterase 11 ACOT11 Tbio Enzyme -2.32299 204.5 165
Epsin-1 EPN1 Tbio Non-IDG -1.52389 32.5 163
Protein kinase C and casein kinase substrate in neurons protein 3 PACSIN3 Tbio Enzyme -0.67239 5.43 259
Platelet glycoprotein 4 CD36 Tbio Non-IDG -2.63884 376.0 1155
Endophilin-A1 SH3GL2 Tbio Non-IDG -1.79540 59.9 248
Endophilin-A3 SH3GL3 Tbio Non-IDG -1.03962 9.87 97
Rho GTPase-activating protein 7 DLC1 Tbio Enzyme -1.93185 106.7 137
StAR-related lipid transfer protein 13 STARD13 Tbio Non-IDG -2.03717 75.4 82
Extended synaptotagmin-1 ESYT1 Tbio Non-IDG -1.29290 19.3 161