Development Level

Tbio 88 | 10,625
Tchem 24 | 1,890
Tdark 18 | 7,003
Tclin 6 | 602

Collection

Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

decreased body weight 4 | 174
hypoactivity 4 | 89
abnormal bone structure 3 | 131
decreased body length 3 | 108
decreased circulating serum al... 3 | 79
decreased lean body mass 3 | 195
decreased rib number 3 | 59
decreased total body fat amoun... 3 | 186
enlarged heart 3 | 111
abnormal behavior 2 | 226
abnormal eye size 2 | 11
abnormal lens morphology 2 | 73
decreased bone mineral content 2 | 157
decreased bone mineral density 2 | 126
decreased caudal vertebrae num... 2 | 49
decreased circulating HDL chol... 2 | 77
decreased circulating choleste... 2 | 85
decreased circulating fructosa... 2 | 31
decreased circulating glucose ... 2 | 121
decreased lumbar vertebrae num... 2 | 62
decreased mean corpuscular hem... 2 | 19
decreased mean corpuscular vol... 2 | 50
decreased prepulse inhibition 2 | 52
decreased threshold for audito... 2 | 32
increased circulating HDL chol... 2 | 63
increased circulating LDL chol... 2 | 15
increased circulating alkaline... 2 | 119
increased circulating choleste... 2 | 53
increased circulating free fat... 2 | 17
increased or absent threshold ... 2 | 128
increased sacral vertebrae num... 2 | 62
preweaning lethality, complete... 2 | 633
preweaning lethality, incomple... 2 | 260
abnormal coat/ hair morphology 1 | 18
abnormal coat/hair pigmentatio... 1 | 54
abnormal cornea morphology 1 | 24
abnormal eye morphology 1 | 38
abnormal hair growth 1 | 8
abnormal heart morphology 1 | 51
abnormal liver morphology 1 | 5
abnormal rib morphology 1 | 28
abnormal seminal vesicle morph... 1 | 47
abnormal sleep behavior 1 | 63
abnormal tail morphology 1 | 17
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
abnormal vibrissa morphology 1 | 17
absent pinna reflex 1 | 21
decreased CD8-positive, naive ... 1 | 5
decreased Ly6C high monocyte n... 1 | 18
decreased Ly6C low monocyte nu... 1 | 23
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating aspartat... 1 | 27
decreased circulating sodium l... 1 | 18
decreased circulating total pr... 1 | 41
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased grip strength 1 | 123
decreased hematocrit 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased mean platelet volume 1 | 12
decreased monocyte cell number 1 | 28
decreased thoracic vertebrae n... 1 | 7
decreased total retina thickne... 1 | 20
decreased vertical activity 1 | 22
hydrometra 1 | 13
improved glucose tolerance 1 | 56
increased Ly6C high monocyte n... 1 | 12
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 43
increased circulating fructosa... 1 | 11
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased fasted circulating g... 1 | 68
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 93
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
increased memory CD4-positive,... 1 | 3
persistence of hyaloid vascula... 1 | 22
short tibia 1 | 82
shortened ST segment 1 | 9
small superior vagus ganglion 1 | 20
vertebral fusion 1 | 23

Disease

ovarian cancer 60 | 8,484
psoriasis 59 | 6,685
osteosarcoma 56 | 7,933
medulloblastoma, large-cell 42 | 6,234
glioblastoma 39 | 5,572
lung cancer 38 | 4,466
lung adenocarcinoma 31 | 2,713
atypical teratoid / rhabdoid tumor 29 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 26 | 3,289
oligodendroglioma 26 | 2,849
diabetes mellitus 25 | 1,663
lung carcinoma 25 | 2,844
interstitial cystitis 24 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 24 | 2,956
non-small cell lung cancer 24 | 2,798
invasive ductal carcinoma 22 | 2,950
pancreatic ductal adenocarcinoma liver metastasis 22 | 1,795
pediatric high grade glioma 22 | 2,712
primitive neuroectodermal tumor 22 | 3,031
malignant mesothelioma 21 | 3,162
subependymal giant cell astrocytoma 21 | 2,287
intraductal papillary-mucinous carcinoma (IPMC) 20 | 2,988
Cancer 19 | 2,346
pilocytic astrocytoma 19 | 3,086
Breast cancer 18 | 3,094
adult high grade glioma 18 | 2,148
astrocytic glioma 18 | 2,241
astrocytoma 17 | 1,493
group 3 medulloblastoma 17 | 2,254
adrenocortical carcinoma 16 | 1,427
ductal carcinoma in situ 16 | 1,745
ependymoma 16 | 2,514
Obesity 15 | 616
pancreatic cancer 14 | 2,300
ulcerative colitis 14 | 2,087
Pick disease 13 | 1,893
cystic fibrosis 13 | 1,665
group 4 medulloblastoma 13 | 1,875
pituitary cancer 13 | 1,972
Atherosclerosis 12 | 275
Coronary artery disease 12 | 240
breast carcinoma 12 | 1,614
cutaneous lupus erythematosus 12 | 1,056
posterior fossa group A ependymoma 12 | 1,511
atypical teratoid/rhabdoid tumor 11 | 1,095
posterior fossa group B ependymoma 11 | 1,530
sonic hedgehog group medulloblastoma 11 | 1,482
spina bifida 11 | 1,064
tuberculosis 11 | 1,557
Down syndrome 10 | 548
Multiple myeloma 9 | 1,327
Alzheimer's disease 8 | 644
Atopic dermatitis 8 | 944
Carcinoma 8 | 2,147
Lipid metabolism disorder 8 | 102
colon cancer 8 | 1,475
esophageal adenocarcinoma 8 | 737
fibroadenoma 8 | 557
non primary Sjogren syndrome sicca 8 | 840
primary pancreatic ductal adenocarcinoma 8 | 1,271
Endometriosis 7 | 535
Metabolic syndrome X 7 | 155
Prostatic Neoplasms 7 | 471
Waldenstrons macroglobulinemia 7 | 765
active Crohn's disease 7 | 918
acute quadriplegic myopathy 7 | 1,157
gastric carcinoma 7 | 832
juvenile dermatomyositis 7 | 1,189
nasopharyngeal carcinoma 7 | 1,056
Hypertensive disease 6 | 193
Mammary Neoplasms 6 | 410
Parkinson's disease 6 | 364
Peripheral Neuropathy 6 | 303
Schizophrenia 6 | 501
dermatomyositis 6 | 933
medulloblastoma 6 | 1,524
Diabetes Mellitus, Experimental 5 | 106
Drug-Induced Liver Injury 5 | 118
Hypertension 5 | 287
IGA Glomerulonephritis 5 | 454
Multiple Sclerosis 5 | 498
Rheumatoid Arthritis 5 | 1,160
active ulcerative colitis 5 | 477
chronic rhinosinusitis 5 | 512
nephrosclerosis 5 | 329
primary Sjogren syndrome 5 | 789
progressive supranuclear palsy 5 | 674
Amyotrophic Lateral Sclerosis 4 | 431
Asthma 4 | 349
Autistic Disorder 4 | 320
Cardiovascular system disease 4 | 194
Hypertriglyceridemia 4 | 18
Kidney disease 4 | 396
Leukemia 4 | 88
Liver disease 4 | 219
Melanoma 4 | 261
Proteinuria 4 | 63
Reperfusion Injury 4 | 84
acute myeloid leukemia 4 | 780
pancreatic carcinoma 4 | 567

Tissue

Digestive Tract 133 | 18,473
Endocrine System 133 | 18,512
Nervous System 133 | 18,561
Skin and soft tissues 133 | 18,115
Female tissues 132 | 18,647
Liver and Pancreas 132 | 18,136
Urinary Tract 132 | 18,444
Blood and immune system 130 | 17,995
Cardiovascular System 130 | 17,958
Male tissues 129 | 17,969
Respiratory system 129 | 17,484

Target Family

Non-IDG 104 | 11,971
Enzyme 17 | 4,146
GPCR 9 | 406
Kinase 4 | 634
Nuclear Receptor 2 | 48

GO Function

lipid binding 136 | 136
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788