Development Level

Tbio 186 | 10,625
Tdark 31 | 7,003
Tchem 10 | 1,890

IMPC Term

preweaning lethality, complete... 9 | 633
decreased body weight 5 | 174
decreased lean body mass 5 | 195
preweaning lethality, incomple... 5 | 260
abnormal bone structure 4 | 131
abnormal behavior 3 | 226
abnormal retina morphology 3 | 100
decreased bone mineral content 3 | 157
abnormal bone mineralization 2 | 55
abnormal embryo size 2 | 112
abnormal eye morphology 2 | 38
abnormal sleep behavior 2 | 63
abnormal spleen morphology 2 | 36
decreased CD4-positive, CD25-p... 2 | 24
decreased body length 2 | 108
decreased bone mineral density 2 | 126
decreased circulating alanine ... 2 | 53
decreased circulating aspartat... 2 | 27
decreased eosinophil cell numb... 2 | 41
decreased grip strength 2 | 123
decreased heart weight 2 | 44
decreased total body fat amoun... 2 | 186
hyperactivity 2 | 108
hypoactivity 2 | 89
increased mean corpuscular vol... 2 | 91
increased monocyte cell number 2 | 27
increased or absent threshold ... 2 | 128
abnormal behavioral response t... 1 | 52
abnormal coat/ hair morphology 1 | 18
abnormal coat/hair pigmentatio... 1 | 54
abnormal coping response 1 | 12
abnormal digit morphology 1 | 13
abnormal forebrain development 1 | 18
abnormal heart left ventricle ... 1 | 20
abnormal hindbrain development 1 | 24
abnormal hindlimb morphology 1 | 2
abnormal iris morphology 1 | 12
abnormal limb position 1 | 3
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal retinal blood vessel ... 1 | 18
abnormal retinal pigmentation 1 | 61
abnormal seminal vesicle morph... 1 | 47
abnormal skin morphology 1 | 23
abnormal spinal cord morpholog... 1 | 8
abnormal tail movements 1 | 12
abnormal vocalization 1 | 21
decreased B cell number 1 | 30
decreased CD8-positive, alpha-... 1 | 26
decreased KLRG1-positive NK ce... 1 | 9
decreased NK cell number 1 | 16
decreased basophil cell number 1 | 11
decreased blood urea nitrogen ... 1 | 31
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased circulating alkaline... 1 | 41
decreased circulating bilirubi... 1 | 14
decreased circulating chloride... 1 | 32
decreased circulating free fat... 1 | 39
decreased circulating fructosa... 1 | 31
decreased circulating insulin ... 1 | 75
decreased circulating serum al... 1 | 79
decreased circulating total pr... 1 | 41
decreased circulating triglyce... 1 | 83
decreased heart rate 1 | 10
decreased lactate dehydrogenas... 1 | 14
decreased prepulse inhibition 1 | 52
decreased startle reflex 1 | 48
decreased threshold for audito... 1 | 32
decreased total retina thickne... 1 | 20
decreased vertical activity 1 | 22
dilated heart left ventricle 1 | 10
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
enlarged heart 1 | 111
enlarged spleen 1 | 26
female infertility 1 | 34
hydrops fetalis 1 | 22
improved glucose tolerance 1 | 56
increased B cell number 1 | 23
increased bone mineral content 1 | 92
increased circulating alkaline... 1 | 119
increased circulating calcium ... 1 | 32
increased effector memory CD4-... 1 | 15
increased exploration in new e... 1 | 56
increased fasted circulating g... 1 | 68
increased gamma-delta T cell n... 1 | 16
increased heart rate 1 | 17
increased hematocrit 1 | 36
increased mature B cell number 1 | 12
increased mean corpuscular hem... 1 | 25
male infertility 1 | 62
narrow eye opening 1 | 15
polydactyly 1 | 22
prenatal lethality prior to he... 1 | 64
prolonged RR interval 1 | 2
shortened QT interval 1 | 4
shortened RR interval 1 | 19
shortened ST segment 1 | 9
straub tail 1 | 26

Disease

ovarian cancer 139 | 8,484
osteosarcoma 119 | 7,933
medulloblastoma, large-cell 80 | 6,234
psoriasis 68 | 6,685
glioblastoma 64 | 5,572
lung cancer 53 | 4,466
atypical teratoid / rhabdoid tumor 51 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 43 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 39 | 2,988
Breast cancer 37 | 3,094
Carcinoma 37 | 2,147
malignant mesothelioma 37 | 3,162
subependymal giant cell astrocytoma 37 | 2,287
Cancer 36 | 2,346
intraductal papillary-mucinous adenoma (IPMA) 35 | 2,956
adult high grade glioma 33 | 2,148
pilocytic astrocytoma 32 | 3,086
juvenile dermatomyositis 31 | 1,189
primitive neuroectodermal tumor 31 | 3,031
oligodendroglioma 30 | 2,849
Pick disease 29 | 1,893
group 3 medulloblastoma 29 | 2,254
group 4 medulloblastoma 28 | 1,875
astrocytic glioma 27 | 2,241
ependymoma 26 | 2,514
lung adenocarcinoma 26 | 2,713
pancreatic cancer 26 | 2,300
Multiple myeloma 25 | 1,327
Rheumatoid Arthritis 25 | 1,160
lung carcinoma 24 | 2,844
ulcerative colitis 24 | 2,087
non-small cell lung cancer 23 | 2,798
invasive ductal carcinoma 21 | 2,950
acute quadriplegic myopathy 20 | 1,157
tuberculosis and treatment for 6 months 20 | 686
breast carcinoma 19 | 1,614
interstitial cystitis 19 | 2,299
sonic hedgehog group medulloblastoma 19 | 1,482
spina bifida 19 | 1,064
tuberculosis 19 | 1,557
dermatomyositis 18 | 933
pediatric high grade glioma 18 | 2,712
cystic fibrosis 17 | 1,665
medulloblastoma 17 | 1,524
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,795
astrocytoma 15 | 1,493
atypical teratoid/rhabdoid tumor 15 | 1,095
acute myeloid leukemia 14 | 780
adrenocortical carcinoma 14 | 1,427
pituitary cancer 14 | 1,972
active Crohn's disease 13 | 918
ductal carcinoma in situ 13 | 1,745
posterior fossa group B ependymoma 13 | 1,530
primary Sjogren syndrome 13 | 789
primary pancreatic ductal adenocarcinoma 13 | 1,271
progressive supranuclear palsy 13 | 674
Waldenstrons macroglobulinemia 12 | 765
posterior fossa group A ependymoma 12 | 1,511
diabetes mellitus 11 | 1,663
cutaneous lupus erythematosus 10 | 1,056
glioblastoma multiforme 10 | 347
hepatocellular carcinoma 10 | 532
Atopic dermatitis 9 | 944
Multiple Sclerosis 9 | 498
esophageal adenocarcinoma 9 | 737
gastric carcinoma 9 | 832
Alzheimer's disease 8 | 644
Intellectual disability 8 | 573
aldosterone-producing adenoma 8 | 664
colon cancer 8 | 1,475
Amyotrophic Lateral Sclerosis 7 | 431
Neurodegenerative disease 7 | 383
Mammary Neoplasms 6 | 410
Parkinson's disease 6 | 364
hereditary spastic paraplegia 6 | 313
non primary Sjogren syndrome sicca 6 | 840
pancreatic carcinoma 6 | 567
sarcoidosis 6 | 358
Autistic Disorder 5 | 320
Gaucher disease type 1 5 | 171
IGA Glomerulonephritis 5 | 454
chronic rhinosinusitis 5 | 512
gastric cancer 5 | 430
Acquired metabolic disease 4 | 267
Chronic Lymphocytic Leukemia 4 | 242
Esophageal Neoplasms 4 | 67
HIV Infections 4 | 100
Neuropathy 4 | 210
Nijmegen breakage syndrome 4 | 23
Opitz-GBBB syndrome 4 | 19
Prostatic Neoplasms 4 | 471
Stomach Neoplasms 4 | 282
inflammatory breast cancer 4 | 404
mucosa-associated lymphoid tissue lymphoma 4 | 480
nasopharyngeal carcinoma 4 | 1,056
Attention deficit hyperactivity disorder 3 | 156
Duchenne muscular dystrophy 3 | 602
Endometriosis 3 | 535
Juvenile arthritis 3 | 124
urothelial carcinoma 3 | 318

Tissue

Digestive Tract 224 | 18,473
Female tissues 224 | 18,647
Nervous System 224 | 18,561
Cardiovascular System 223 | 17,958
Endocrine System 223 | 18,512
Liver and Pancreas 223 | 18,136
Skin and soft tissues 223 | 18,115
Urinary Tract 223 | 18,444
Blood and immune system 222 | 17,995
Male tissues 221 | 17,969
Respiratory system 220 | 17,484

Target Family

Enzyme 175 | 4,146
Non-IDG 33 | 11,971
Transcription Factor 10 | 1,400
Epigenetic 9 | 242

GO Function

ligase activity 227 | 227
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interferon regulatory factor 2-binding protein 1 IRF2BP1 Tdark Non-IDG -0.29200 1.63 121
V(D)J recombination-activating protein 1 RAG1 Tbio Non-IDG -3.00063 1061.1 65
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
E3 ubiquitin-protein ligase TRIM31 TRIM31 Tbio Enzyme -2.12276 133.1 126
TNF receptor-associated factor 2 TRAF2 Tbio Non-IDG -1.85843 68.9 516
E3 ubiquitin-protein ligase ZSWIM2 ZSWIM2 Tbio Enzyme -2.21919 171.7 87
Transcription factor E4F1 E4F1 Tbio Transcription Factor -1.47845 33.6 74
E3 ubiquitin-protein ligase TRIM62 TRIM62 Tbio Enzyme -0.57145 6.96 129
Nicotinate phosphoribosyltransferase NAPRT Tbio Enzyme -1.20896 15.7 91
DNA ligase 4 LIG4 Tbio Enzyme -2.11773 136.0 194