Development Level

Tbio 48 | 11,651
Tchem 15 | 1,388
Tdark 5 | 6,593

IMPC Phenotype

preweaning lethality, complete... 18 | 979
embryonic lethality prior to o... 6 | 239
abnormal bone structure 4 | 187
embryonic lethality prior to t... 4 | 278
abnormal embryo size 3 | 220
decreased bone mineral content 3 | 151
decreased grip strength 3 | 116
decreased lean body mass 3 | 135
abnormal behavior 2 | 298
decreased bone mineral density 2 | 126
decreased fasted circulating g... 2 | 65
decreased mean corpuscular vol... 2 | 79
decreased total body fat amoun... 2 | 207
impaired glucose tolerance 2 | 75
increased circulating alkaline... 2 | 122
increased mean corpuscular vol... 2 | 92
increased red blood cell distr... 2 | 34
increased total body fat amoun... 2 | 134
abnormal QT variability 1 | 10
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal digit morphology 1 | 10
abnormal esophagus morphology 1 | 5
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal social-conspecific in... 1 | 3
abnormal spinal cord morpholog... 1 | 9
abnormal spine curvature 1 | 9
abnormal tooth morphology 1 | 24
cataract 1 | 92
decreased body length 1 | 101
decreased body weight 1 | 161
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating chloride... 1 | 30
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased red blood cell distr... 1 | 41
decreased urine magnesium leve... 1 | 3
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
enlarged gallbladder 1 | 2
enlarged heart 1 | 210
enlarged kidney 1 | 14
enlarged spleen 1 | 41
hyperactivity 1 | 148
increased blood urea nitrogen ... 1 | 48
increased circulating HDL chol... 1 | 80
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11
increased erythrocyte cell num... 1 | 39
increased exploration in new e... 1 | 8
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased large unstained cell... 1 | 5
increased lean body mass 1 | 172
increased neutrophil cell numb... 1 | 46
increased thermal nociceptive ... 1 | 9
tremors 1 | 39

Disease

Carcinoma 61 | 11,493
ovarian cancer 46 | 8,520
osteosarcoma 28 | 7,950
psoriasis 26 | 6,694
lung cancer 25 | 4,740
medulloblastoma, large-cell 21 | 6,241
glioblastoma 18 | 5,792
Autosomal recessive predisposition 17 | 1,442
atypical teratoid / rhabdoid tumor 17 | 5,112
Cancer 16 | 2,499
Multiple myeloma 16 | 1,332
Kidney cancer 12 | 2,613
Neurodegenerative disease 11 | 414
diabetes mellitus 11 | 1,728
malignant mesothelioma 11 | 3,232
tuberculosis 11 | 2,010
Breast cancer 10 | 3,578
ependymoma 10 | 4,679
group 3 medulloblastoma 10 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
juvenile dermatomyositis 10 | 1,187
Myositis 9 | 30
Neuropathy 9 | 261
acute myeloid leukemia 9 | 783
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
non-small cell lung cancer 9 | 2,890
oligodendroglioma 9 | 2,850
Distal sensory impairment 8 | 52
Pick disease 8 | 1,894
acute quadriplegic myopathy 8 | 1,158
dermatomyositis 8 | 966
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
primitive neuroectodermal tumor 8 | 3,035
Charcot-Marie-Tooth disease 7 | 62
Cognitive delay 7 | 608
Epilepsy 7 | 792
Global developmental delay 7 | 608
Mental and motor retardation 7 | 608
Muscle hypotonia 7 | 571
Nystagmus 7 | 317
adult high grade glioma 7 | 3,801
astrocytic glioma 7 | 2,597
Failure to gain weight 6 | 365
Pediatric failure to thrive 6 | 365
Rheumatoid arthritis 6 | 1,191
Small head 6 | 374
Waldenstrons macroglobulinemia 6 | 765
astrocytoma 6 | 1,146
colon cancer 6 | 1,478
lung adenocarcinoma 6 | 2,716
subependymal giant cell astrocytoma 6 | 2,287
Anemia 5 | 365
Astrocytoma, Pilocytic 5 | 3,081
Congenital pes cavus 5 | 88
Decreased tendon reflex 5 | 122
Highly variable severity 5 | 157
Leigh disease 5 | 100
Progressive disorder 5 | 142
Variable expressivity 5 | 157
active Crohn's disease 5 | 922
breast carcinoma 5 | 1,638
pancreatic cancer 5 | 2,398
Absent reflex 4 | 92
Absent tendon reflex 4 | 92
Alpers syndrome 4 | 9
Autosomal recessive Robinow syndrome 4 | 27
Cerebral atrophy 4 | 178
Degenerative brain disorder 4 | 100
Distal limb muscle weakness due to peripheral neuropathy 4 | 62
Distal muscle weakness 4 | 62
Foot dorsiflexor weakness 4 | 27
Foot-drop 4 | 27
Gait, Drop Foot 4 | 24
Hammer Toe 4 | 23
Hemoglobin low 4 | 124
Hyperreflexia 4 | 209
Intellectual disability 4 | 1,016
Motor delay 4 | 147
No development of motor milestones 4 | 147
Peripheral Neuropathy 4 | 134
Reflex, Deep Tendon, Absent 4 | 92
Supratentorial atrophy 4 | 94
cystic fibrosis 4 | 1,696
group 4 medulloblastoma 4 | 1,855
interstitial cystitis 4 | 2,312
interstitial lung disease 4 | 298
invasive ductal carcinoma 4 | 2,951
medulloblastoma 4 | 720
pituitary cancer 4 | 1,972
progressive supranuclear palsy 4 | 676
sonic hedgehog group medulloblastoma 4 | 467
Acquired scoliosis 3 | 281
Attention deficit hyperactivity disorder 3 | 278
Bipolar Disorder 3 | 666
Curvature of spine 3 | 282
Hepatomegaly 3 | 285
chronic rhinosinusitis 3 | 512
esophageal adenocarcinoma 3 | 737
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pediatric high grade glioma 3 | 1,064

Tissue

Endocrine System 68 | 18,159
Liver and Pancreas 68 | 16,750
Blood and immune system 67 | 16,909
Female tissues 67 | 17,400
Male tissues 67 | 17,142
Nervous System 67 | 16,725
Respiratory system 67 | 16,393
Skin and soft tissues 67 | 17,230
Urinary Tract 67 | 16,678
Cardiovascular System 66 | 15,192
Digestive Tract 66 | 17,369

Target Family

Enzyme 55 | 4,145
Non-IDG 6 | 12,091
Transcription Factor 6 | 1,400
Epigenetic 1 | 242

GO Function

ligase activity 68 | 68
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase MSL2 MSL2 Tbio Enzyme -1.78868 59.2 117
Probable tubulin polyglutamylase TTLL2 TTLL2 Tdark Enzyme 0.48 0.33 16
Serine--tRNA ligase, cytoplasmic SARS Tbio Enzyme -2.37540 230.1 178
Probable histidine--tRNA ligase, mitochondrial HARS2 Tbio Enzyme -2.45127 269.2 93
Non-structural maintenance of chromosomes element 1 homolog NSMCE1 Tdark Non-IDG 0.00000 103
Tyrosine--tRNA ligase, mitochondrial YARS2 Tbio Enzyme -2.13699 138.7 93
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.41690 2313.9 1252
Nicotinate phosphoribosyltransferase NAPRT Tbio Enzyme -1.26235 18.2 103
E3 ubiquitin-protein ligase RBX1 RBX1 Tbio Enzyme -1.94266 72.1 260
E3 SUMO-protein ligase RanBP2 RANBP2 Tbio Enzyme -2.24609 178.6 172