Development Level

Tclin 16 | 613
Tchem 9 | 1,598
Tbio 7 | 11,445

Collection

Ion Channel: IDG Consortium (T... 5 | 99

IMPC Phenotype

decreased body weight 3 | 161
decreased total body fat amoun... 3 | 207
increased circulating sodium l... 3 | 71
abnormal behavior 2 | 298
decreased bone mineral content 2 | 151
enlarged heart 2 | 210
increased lean body mass 2 | 172
increased startle reflex 2 | 112
preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal epididymis morphology 1 | 42
abnormal eye size 1 | 7
abnormal joint morphology 1 | 23
abnormal retinal blood vessel ... 1 | 26
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal vibrissa morphology 1 | 25
brachydactyly 1 | 19
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased exploration in new e... 1 | 11
decreased grip strength 1 | 116
decreased mean corpuscular hem... 1 | 31
decreased vertical activity 1 | 208
enlarged spleen 1 | 41
enlarged uterus 1 | 11
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased mean corpuscular vol... 1 | 92
increased total body fat amoun... 1 | 134
mydriasis 1 | 6
preweaning lethality, complete... 1 | 979
syndactyly 1 | 23
tremors 1 | 39

Disease

Carcinoma 26 | 11,493
psoriasis 19 | 6,694
Schizophrenia 15 | 1,160
Nicotine dependence 13 | 54
Bipolar Disorder 12 | 666
glioblastoma 12 | 5,792
medulloblastoma, large-cell 12 | 6,241
osteosarcoma 12 | 7,950
Epilepsy 11 | 792
atypical teratoid / rhabdoid tumor 11 | 5,112
adult high grade glioma 10 | 3,801
ependymoma 10 | 4,679
astrocytic glioma 9 | 2,597
lung carcinoma 9 | 2,843
oligodendroglioma 9 | 2,850
Alcoholic Intoxication, Chronic 8 | 289
Autosomal recessive predisposition 8 | 1,442
group 3 medulloblastoma 8 | 4,104
lung cancer 8 | 4,740
primitive neuroectodermal tumor 8 | 3,035
Alcohol dependence 7 | 107
Autistic Disorder 7 | 364
Frontal lobe epilepsy 7 | 10
Kidney cancer 7 | 2,613
Muscle relaxation, function 7 | 8
Seizures 7 | 596
ovarian cancer 7 | 8,520
subependymal giant cell astrocytoma 7 | 2,287
Astrocytoma, Pilocytic 6 | 3,081
Depressive disorder 6 | 409
General anesthesia 6 | 53
Mental Depression 6 | 333
Smoking cessation assistance 6 | 8
Tonic-clonic epilepsy 6 | 47
Attention deficit hyperactivity disorder 5 | 278
Blepharoptosis 5 | 231
Byzanthine arch palate 5 | 194
Cocaine Dependence 5 | 51
Epilepsy characterized by intractable complex partial seizures 5 | 28
Intellectual disability 5 | 1,016
Lennox-Gastaut syndrome 5 | 34
Lung Neoplasms 5 | 232
Migraine Prevention 5 | 23
Multiple pterygium syndrome 5 | 18
Niacin deficiency 5 | 5
Nicotine Withdrawal Symptoms 5 | 5
Ophthalmoplegia 5 | 106
Pellagra 5 | 26
Simple partial seizure 5 | 26
Skeletal Muscle Relaxation for Endotracheal Intubation 5 | 5
Skeletal Muscle Relaxation for Endotracheal Intubation in C-Section 5 | 5
TOBACCO ADDICTION, SUSCEPTIBILITY TO 5 | 12
TOBACCO ADDICTION, SUSCEPTIBILITY TO (finding) 5 | 12
pituitary cancer 5 | 1,972
substance-related disorder 5 | 162
Alzheimer's disease 4 | 658
Bell Palsy 4 | 58
Breast cancer 4 | 3,578
Cleft Palate 4 | 271
Congenital Myasthenic Syndromes, Postsynaptic 4 | 11
Congenital myasthenic syndrome 4 | 25
Easy fatigability 4 | 18
Facial Paresis 4 | 59
Facial muscle weakness of muscles innervated by CN VII 4 | 58
Feeding difficulties 4 | 127
Infantile onset 4 | 238
Muscle hypotonia 4 | 571
Myasthenic Syndrome, Congenital, 1A, Slow-Channel 4 | 4
Myasthenic syndrome, congenital, postsynaptic slow-channel 4 | 4
Neonatal Hypotonia 4 | 64
Neuropathy 4 | 261
Pick disease 4 | 1,894
Substance Withdrawal Syndrome 4 | 55
Tires quickly 4 | 18
group 4 medulloblastoma 4 | 1,855
lung adenocarcinoma 4 | 2,716
malignant mesothelioma 4 | 3,232
Abnormal behavior 3 | 52
Amyotrophic lateral sclerosis 3 | 451
Chronic obstructive pulmonary disease 3 | 184
Congenital Epicanthus 3 | 177
Congenital anomaly of face 3 | 56
Contracture 3 | 96
Contracture of joint 3 | 93
Dysmorphic facies 3 | 46
Flexion contracture 3 | 93
Flexion contractures of joints 3 | 93
Increased susceptibility to fractures 3 | 21
Liver cancer 3 | 604
Major Depressive Disorder 3 | 301
Mood Disorders 3 | 184
Toxic encephalopathy 3 | 141
Unipolar Depression 3 | 250
active Crohn's disease 3 | 922
acute quadriplegic myopathy 3 | 1,158
colon cancer 3 | 1,478
cystic fibrosis 3 | 1,696
facial deformity 3 | 46
pediatric high grade glioma 3 | 1,064
pterygium 3 | 76

Tissue

Endocrine System 30 | 18,159
Nervous System 29 | 16,725
Female tissues 28 | 17,400
Digestive Tract 27 | 17,369
Liver and Pancreas 27 | 16,750
Male tissues 27 | 17,142
Skin and soft tissues 27 | 17,230
Blood and immune system 26 | 16,909
Urinary Tract 26 | 16,678
Respiratory system 24 | 16,393
Cardiovascular System 17 | 15,192

Target Family

Ion Channel 26 | 344
Non-IDG 6 | 12,091

GO Function

ligand-gated ion channel activ... 32 | 32
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Neuronal acetylcholine receptor subunit beta-2 CHRNB2 Tclin Ion Channel -1.62448 37.6 174
Acetylcholine receptor subunit alpha CHRNA1 Tclin Ion Channel -1.66400 41.7 307
Neuronal acetylcholine receptor subunit alpha-7 CHRFAM7A Tchem Ion Channel -1.81173 87.7 226
Neurocalcin-delta NCALD Tbio Non-IDG -1.30940 20.7 102
Glutamate receptor ionotropic, kainate 4 GRIK4 Tclin Ion Channel -2.19499 147.3 105
Annexin A6 ANXA6 Tbio Non-IDG -2.44893 298.8 381
Gamma-aminobutyric acid receptor subunit beta-1 GABRB1 Tclin Ion Channel -1.35520 21.7 309
Glutamate receptor ionotropic, kainate 5 GRIK5 Tclin Ion Channel -2.11616 127.3 179
Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 Tchem Ion Channel -1.31722 18.3 117
Glutamate receptor ionotropic, kainate 1 GRIK1 Tclin Ion Channel -2.44487 279.7 219