Development Level

Tbio 6 | 11,445

IMPC Phenotype

preweaning lethality, incomple... 2 | 499
abnormal heart morphology 1 | 162
abnormal liver morphology 1 | 17
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
increased aggression 1 | 4
prenatal lethality prior to he... 1 | 87

Disease

Carcinoma 6 | 11,493
medulloblastoma, large-cell 5 | 6,241
atypical teratoid / rhabdoid tumor 4 | 5,112
glioblastoma 4 | 5,792
osteosarcoma 4 | 7,950
ovarian cancer 4 | 8,520
psoriasis 4 | 6,694
Down syndrome 2 | 499
Generalized dystonia 2 | 4
Intellectual disability 2 | 1,016
Johanson-Blizzard syndrome 2 | 4
Kidney cancer 2 | 2,613
Rapadilino syndrome 2 | 7
adult high grade glioma 2 | 3,801
group 3 medulloblastoma 2 | 4,104
group 4 medulloblastoma 2 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
primitive neuroectodermal tumor 2 | 3,035
Astrocytoma, Pilocytic 1 | 3,081
Asymptomatic hyperammonemia 1 | 1
Cancer 1 | 2,499
Chemical and Drug Induced Liver Injury 1 | 195
Dull intelligence 1 | 645
Exocrine pancreatic insufficiency 1 | 32
Fetal Growth Retardation 1 | 189
Hepatomegaly 1 | 285
Hyperammonemia 1 | 30
Hyperinsulinaemic hypoglycaemia 1 | 16
Hyperinsulinemic hypoglycemia 1 | 17
Hyperinsulinemic hypoglycemia, familial, 6 1 | 1
Hyperinsulinism 1 | 133
Hypoglycaemic seizure 1 | 10
Hypoglycemia 1 | 152
Hypoglycemic coma 1 | 10
Imperforate anus 1 | 25
Johanson Blizzard syndrome 1 | 1
Joubert syndrome 1 | 66
Liver cancer 1 | 604
Low intelligence 1 | 645
Male infertility 1 | 206
Meckel syndrome 1 | 46
Mental Retardation 1 | 645
Mental deficiency 1 | 645
Multiple myeloma 1 | 1,332
PARKINSON DISEASE, LATE-ONSET 1 | 20
Pick disease 1 | 1,894
Poor school performance 1 | 645
Right atrial isomerism 1 | 29
Rothmund-Thomson syndrome 1 | 19
Sensorineural hearing loss 1 | 106
Thrombocytopenia 1 | 197
Tooth agenesis 1 | 44
Waldenstrons macroglobulinemia 1 | 765
colon cancer 1 | 1,478
esophageal adenocarcinoma 1 | 737
intraductal papillary-mucinous neoplasm (IPMN) 1 | 3,291
invasive ductal carcinoma 1 | 2,951
juvenile dermatomyositis 1 | 1,187
lung adenocarcinoma 1 | 2,716
lung cancer 1 | 4,740
malignant mesothelioma 1 | 3,232
non primary Sjogren syndrome sicca 1 | 891
non-small cell lung cancer 1 | 2,890
pediatric high grade glioma 1 | 1,064
subependymal giant cell astrocytoma 1 | 2,287
tuberculosis 1 | 2,010

Tissue

Blood and immune system 6 | 16,909
Cardiovascular System 6 | 15,192
Digestive Tract 6 | 17,369
Endocrine System 6 | 18,159
Female tissues 6 | 17,400
Liver and Pancreas 6 | 16,750
Male tissues 6 | 17,142
Nervous System 6 | 16,725
Respiratory system 6 | 16,393
Skin and soft tissues 6 | 17,230
Urinary Tract 6 | 16,678

Target Family

Enzyme 4 | 4,145
Non-IDG 2 | 12,091

GO Function

leucine binding 6 | 6
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Glutamate dehydrogenase 1, mitochondrial GLUD1 Tbio Enzyme -2.39787 257.7 148
E3 ubiquitin-protein ligase UBR1 UBR1 Tbio Enzyme -1.95732 91.8 136
Sestrin-1 SESN1 Tbio Non-IDG -1.95681 82.0 172
Sestrin-2 SESN2 Tbio Non-IDG -1.88129 92.6 176
E3 ubiquitin-protein ligase UBR2 UBR2 Tbio Enzyme -1.32729 22.3 158
Glutamate dehydrogenase 2, mitochondrial GLUD2 Tbio Enzyme -1.21617 14.6 164