Development Level

Tbio 34 | 11,178
Tchem 3 | 1,885
Tclin 2 | 612
Tdark 1 | 6,569

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 6 | 979
abnormal embryo size 2 | 220
cyanosis 2 | 7
abnormal behavioral response t... 1 | 66
abnormal facial morphology 1 | 17
abnormal head shape 1 | 10
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal outer ear morphology 1 | 3
absent pinna reflex 1 | 23
cataract 1 | 92
decreased body weight 1 | 161
decreased circulating glucose ... 1 | 126
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
hemorrhage 1 | 23
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased circulating chloride... 1 | 41
increased circulating glucose ... 1 | 24
increased circulating sodium l... 1 | 71
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
persistence of hyaloid vascula... 1 | 33

Disease

Carcinoma 36 | 11,192
ovarian cancer 27 | 8,297
medulloblastoma, large-cell 25 | 6,086
adult high grade glioma 23 | 3,701
atypical teratoid / rhabdoid tumor 22 | 4,971
glioblastoma 22 | 5,635
group 3 medulloblastoma 21 | 4,002
ependymoma 20 | 4,559
osteosarcoma 18 | 7,766
Astrocytoma, Pilocytic 15 | 3,006
psoriasis 15 | 6,514
subependymal giant cell astrocytoma 15 | 2,230
lung cancer 14 | 4,607
primitive neuroectodermal tumor 14 | 2,957
lung adenocarcinoma 12 | 2,627
oligodendroglioma 12 | 2,768
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,902
non-small cell lung cancer 11 | 2,799
Pick disease 10 | 1,856
astrocytic glioma 10 | 2,530
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,204
lung carcinoma 9 | 2,755
Breast cancer 8 | 3,469
invasive ductal carcinoma 8 | 2,867
pituitary cancer 8 | 1,915
Kidney cancer 7 | 2,548
Intellectual disability 6 | 998
group 4 medulloblastoma 6 | 1,806
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,872
pancreatic cancer 6 | 2,322
Alzheimer's disease 5 | 640
Amyotrophic lateral sclerosis 5 | 437
Atopic dermatitis 5 | 915
Cancer 5 | 2,388
Depressive disorder 5 | 401
Dystonia 5 | 163
Multiple Sclerosis 5 | 527
Neurodegenerative disease 5 | 402
Neuropathy 5 | 254
Rheumatoid arthritis 5 | 1,156
astrocytoma 5 | 1,113
breast carcinoma 5 | 1,589
cutaneous lupus erythematosus 5 | 1,016
malignant mesothelioma 5 | 3,135
ulcerative colitis 5 | 1,765
Autosomal recessive predisposition 4 | 1,407
Epilepsy 4 | 775
Schizophrenia 4 | 1,136
acute myeloid leukemia 4 | 760
colon cancer 4 | 1,428
ductal carcinoma in situ 4 | 1,686
interstitial cystitis 4 | 2,237
nasopharyngeal carcinoma 4 | 1,024
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,911
tuberculosis 4 | 1,963
Acquired scoliosis 3 | 274
Autistic Disorder 3 | 358
Bipolar Disorder 3 | 646
Cleft Palate 3 | 265
Curvature of spine 3 | 275
Deglutition Disorders 3 | 128
Down syndrome 3 | 480
Dull intelligence 3 | 634
Endometriosis 3 | 521
Lissencephaly 3 | 69
Liver Cirrhosis, Experimental 3 | 733
Low intelligence 3 | 634
Mental Retardation 3 | 634
Mental deficiency 3 | 634
Muscle hypotonia 3 | 562
Myoclonus 3 | 71
Nerve Degeneration 3 | 118
Poor school performance 3 | 634
Progressive disorder 3 | 139
Seizures 3 | 584
Tremor 3 | 112
adrenocortical carcinoma 3 | 1,385
chronic rhinosinusitis 3 | 505
cystic fibrosis 3 | 1,629
head and neck cancer and chronic obstructive pulmonary disease 3 | 226
hereditary spastic paraplegia 3 | 313
non primary Sjogren syndrome sicca 3 | 861
pediatric high grade glioma 3 | 1,035
posterior fossa group A ependymoma 3 | 456
progressive supranuclear palsy 3 | 656
spina bifida 3 | 1,053
urothelial carcinoma 3 | 303
Broad flat nasal bridge 2 | 232
Chronic obstructive pulmonary disease 2 | 175
Major Depressive Disorder 2 | 293
Mental Depression 2 | 325
Nasal bridge wide 2 | 232
Unipolar Depression 2 | 244
active Crohn's disease 2 | 882
active ulcerative colitis 2 | 736
dermatomyositis 2 | 941
diabetes mellitus 2 | 1,683
gastric carcinoma 2 | 781
mucosa-associated lymphoid tissue lymphoma 2 | 473
primary pancreatic ductal adenocarcinoma 2 | 1,071

Tissue

Blood and immune system 40 | 16,909
Digestive Tract 40 | 17,369
Endocrine System 40 | 18,159
Female tissues 40 | 17,400
Liver and Pancreas 40 | 16,750
Male tissues 40 | 17,142
Nervous System 40 | 16,725
Respiratory system 40 | 16,393
Skin and soft tissues 40 | 17,230
Urinary Tract 40 | 16,678
Cardiovascular System 35 | 15,192

Target Family

Non-IDG 31 | 12,091
Enzyme 6 | 4,145
Ion Channel 2 | 344
Kinase 1 | 634

GO Function

kinesin binding 40 | 40
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
C-Jun-amino-terminal kinase-interacting protein 4 SPAG9 Tbio Enzyme -2.45490 258.6 149
Low-density lipoprotein receptor-related protein 8 LRP8 Tbio Non-IDG -2.17223 148.7 283
C-Jun-amino-terminal kinase-interacting protein 2 MAPK8IP2 Tbio Enzyme -2.78211 570.7 164
Caytaxin ATCAY Tbio Non-IDG -1.07937 14.4 48
Janus kinase and microtubule-interacting protein 1 JAKMIP1 Tbio Enzyme -0.98770 11.3 130
mRNA-decapping enzyme 1A DCP1A Tbio Non-IDG 0.00000 261
Kinectin KTN1 Tbio Non-IDG -1.93411 83.4 89
Doublecortin domain-containing protein 2 DCDC2 Tbio Non-IDG -1.71331 52.4 209
Kinesin heavy chain isoform 5A KIF5A Tbio Non-IDG -1.69131 48.4 170
Pleckstrin homology domain-containing family M member 2 PLEKHM2 Tbio Non-IDG -0.32760 3.56 65