Development Level

Tbio 67 | 11,445
Tchem 15 | 1,598
Tclin 5 | 613
Tdark 5 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

decreased total body fat amoun... 6 | 207
preweaning lethality, complete... 5 | 979
abnormal behavior 4 | 298
decreased circulating HDL chol... 4 | 68
abnormal bone structure 3 | 187
decreased circulating choleste... 3 | 93
abnormal embryo size 2 | 220
decreased body weight 2 | 161
decreased circulating glucose ... 2 | 126
decreased exploration in new e... 2 | 11
hypoactivity 2 | 132
increased circulating chloride... 2 | 41
increased circulating sodium l... 2 | 71
increased lean body mass 2 | 172
increased mean corpuscular vol... 2 | 92
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
preweaning lethality, incomple... 2 | 499
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal eye morphology 1 | 68
abnormal facial morphology 1 | 17
abnormal femur morphology 1 | 14
abnormal head morphology 1 | 10
abnormal head shape 1 | 10
abnormal hindbrain morphology 1 | 10
abnormal iris morphology 1 | 13
abnormal iris pigmentation 1 | 4
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal maxilla morphology 1 | 17
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal outer ear morphology 1 | 3
abnormal pelvic girdle bone mo... 1 | 12
abnormal seminal vesicle morph... 1 | 114
abnormal startle reflex 1 | 15
abnormal vertebrae morphology 1 | 18
abnormal zygomatic bone morpho... 1 | 3
absent pinna reflex 1 | 23
absent urinary bladder 1 | 1
cataract 1 | 92
cyanosis 1 | 7
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased grip strength 1 | 116
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
edema 1 | 59
hemorrhage 1 | 23
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating glucose ... 1 | 24
mammalian phenotype 1 | 17
short tibia 1 | 97
small testis 1 | 58
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Carcinoma 60 | 11,493
ovarian cancer 50 | 8,520
osteosarcoma 46 | 7,950
lung cancer 45 | 4,740
psoriasis 42 | 6,694
glioblastoma 41 | 5,792
medulloblastoma, large-cell 38 | 6,241
Cancer 35 | 2,499
atypical teratoid / rhabdoid tumor 34 | 5,112
group 3 medulloblastoma 31 | 4,104
ependymoma 30 | 4,679
malignant mesothelioma 28 | 3,232
adult high grade glioma 27 | 3,801
primitive neuroectodermal tumor 26 | 3,035
Breast cancer 25 | 3,578
Kidney cancer 23 | 2,613
lung carcinoma 23 | 2,843
Astrocytoma, Pilocytic 22 | 3,081
lung adenocarcinoma 21 | 2,716
non-small cell lung cancer 20 | 2,890
oligodendroglioma 20 | 2,850
astrocytic glioma 19 | 2,597
pancreatic cancer 19 | 2,398
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,291
diabetes mellitus 17 | 1,728
invasive ductal carcinoma 17 | 2,951
subependymal giant cell astrocytoma 17 | 2,287
interstitial cystitis 16 | 2,312
breast carcinoma 15 | 1,638
Multiple myeloma 14 | 1,332
ductal carcinoma in situ 14 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
pituitary cancer 14 | 1,972
primary pancreatic ductal adenocarcinoma 14 | 1,109
Pick disease 13 | 1,894
group 4 medulloblastoma 13 | 1,855
Alzheimer's disease 12 | 658
Autosomal recessive predisposition 12 | 1,442
Schizophrenia 12 | 1,160
colon cancer 12 | 1,478
ulcerative colitis 12 | 1,819
Bipolar Disorder 11 | 666
tuberculosis 11 | 2,010
Amyotrophic lateral sclerosis 10 | 451
Intellectual disability 10 | 1,016
Rheumatoid arthritis 10 | 1,191
adrenocortical carcinoma 10 | 1,428
dermatomyositis 10 | 966
juvenile dermatomyositis 10 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
Breast Neoplasms 9 | 445
Mammary Neoplasms 9 | 425
acute quadriplegic myopathy 9 | 1,158
gastric carcinoma 9 | 807
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
Dull intelligence 8 | 645
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Poor school performance 8 | 645
Waldenstrons macroglobulinemia 8 | 765
cutaneous lupus erythematosus 8 | 1,057
Cognitive delay 7 | 608
Epilepsy 7 | 792
Global developmental delay 7 | 608
Infantile onset 7 | 238
Mental and motor retardation 7 | 608
Neurodegenerative disease 7 | 414
Obesity 7 | 678
Stomach Neoplasms 7 | 300
acute myeloid leukemia 7 | 783
astrocytoma 7 | 1,146
medulloblastoma 7 | 720
Brain Ischemia 6 | 110
Carcinoma, Hepatocellular 6 | 228
Crohn's disease 6 | 321
Depressive disorder 6 | 409
Endometrial cancer 6 | 311
Hypersensitivity reaction type II disease 6 | 253
Immune system cancer 6 | 140
Kidney disease 6 | 430
Liver carcinoma 6 | 240
Lung Neoplasms 6 | 232
Major Depressive Disorder 6 | 301
Melanoma 6 | 711
Mental Depression 6 | 333
Parkinson's disease 6 | 392
Renal Cell Carcinoma 6 | 214
Seizures 6 | 596
Toxic encephalopathy 6 | 141
Unipolar Depression 6 | 250
cystic fibrosis 6 | 1,696
pediatric high grade glioma 6 | 1,064
spina bifida 6 | 1,074
Arthritis 5 | 290
Prostatic Neoplasms 5 | 495
esophageal adenocarcinoma 5 | 737
mucosa-associated lymphoid tissue lymphoma 5 | 484
nephrosclerosis 5 | 333
primary Sjogren syndrome 5 | 735

Tissue

Digestive Tract 91 | 17,369
Endocrine System 91 | 18,159
Female tissues 91 | 17,400
Liver and Pancreas 91 | 16,750
Male tissues 91 | 17,142
Skin and soft tissues 91 | 17,230
Urinary Tract 91 | 16,678
Nervous System 90 | 16,725
Respiratory system 90 | 16,393
Blood and immune system 89 | 16,909
Cardiovascular System 87 | 15,192

Target Family

Non-IDG 54 | 12,091
Enzyme 20 | 4,145
Kinase 11 | 634
Transcription Factor 5 | 1,400
TF/Epigenetic 1 | 38
Transporter 1 | 473

GO Function

kinase binding 92 | 92
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
CCAAT/enhancer-binding protein beta CEBPB Tbio Transcription Factor -2.96589 857.9 436
Myomesin-1 MYOM1 Tbio Non-IDG -1.21420 16.8 127
Protein WWC3 WWC3 Tbio Non-IDG -0.55831 4.90 66
Huntingtin HTT Tchem Non-IDG -3.36282 2294.8 599
High affinity nerve growth factor receptor NTRK1 Tclin Kinase -3.05841 1050.9 1092
Tax1-binding protein 1 TAX1BP1 Tbio Non-IDG -1.44609 30.4 133
Midnolin MIDN Tbio Non-IDG -1.20798 14.4 87
Signaling threshold-regulating transmembrane adapter 1 SIT1 Tdark Non-IDG -0.68059 3.19 152
Lysosomal-associated transmembrane protein 4B LAPTM4B Tbio Non-IDG -1.90763 86.1 91
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116