Development Level

Tchem 47 | 1,598
Tbio 20 | 11,445
Tclin 10 | 613
Tdark 7 | 6,588

Collection

Kinase: IDG Consortium (Target... 7 | 125
Kinase: IDG Consortium (Comple... 3 | 37

IMPC Phenotype

preweaning lethality, complete... 10 | 979
embryonic lethality prior to o... 5 | 239
embryonic lethality prior to t... 5 | 278
preweaning lethality, incomple... 4 | 499
abnormal embryo size 2 | 220
abnormal skin morphology 2 | 50
decreased circulating alanine ... 2 | 47
decreased mean corpuscular hem... 2 | 50
increased circulating magnesiu... 2 | 10
increased mean corpuscular hem... 2 | 96
thrombocytopenia 2 | 56
abnormal behavior 1 | 298
abnormal cornea morphology 1 | 31
abnormal epididymis morphology 1 | 42
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal maxilla morphology 1 | 17
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased circulating LDL chol... 1 | 38
decreased circulating aspartat... 1 | 34
decreased circulating creatini... 1 | 39
decreased circulating serum al... 1 | 82
decreased circulating unsatura... 1 | 2
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean platelet volume 1 | 25
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged heart 1 | 210
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating sodium l... 1 | 71
increased grip strength 1 | 41
increased heart rate 1 | 23
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased startle reflex 1 | 112
male infertility 1 | 123
shortened RR interval 1 | 17
tremors 1 | 39

Disease

Carcinoma 68 | 11,493
osteosarcoma 58 | 7,950
ovarian cancer 54 | 8,520
medulloblastoma, large-cell 45 | 6,241
Cancer 43 | 2,499
atypical teratoid / rhabdoid tumor 38 | 5,112
glioblastoma 37 | 5,792
psoriasis 36 | 6,694
ependymoma 28 | 4,679
lung cancer 27 | 4,740
Breast cancer 26 | 3,578
malignant mesothelioma 26 | 3,232
Kidney cancer 23 | 2,613
adult high grade glioma 23 | 3,801
group 3 medulloblastoma 23 | 4,104
Astrocytoma, Pilocytic 19 | 3,081
primitive neuroectodermal tumor 19 | 3,035
tuberculosis 19 | 2,010
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,989
non-small cell lung cancer 18 | 2,890
oligodendroglioma 18 | 2,850
Schizophrenia 17 | 1,160
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
astrocytic glioma 16 | 2,597
group 4 medulloblastoma 16 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
invasive ductal carcinoma 15 | 2,951
lung carcinoma 15 | 2,843
Pick disease 13 | 1,894
Rheumatoid arthritis 13 | 1,191
lung adenocarcinoma 13 | 2,716
Intellectual disability 12 | 1,016
Parkinson's disease 12 | 392
Renal Cell Carcinoma 12 | 214
subependymal giant cell astrocytoma 12 | 2,287
ulcerative colitis 12 | 1,819
Vascular disease 11 | 319
astrocytoma 11 | 1,146
colon cancer 11 | 1,478
diabetes mellitus 11 | 1,728
pancreatic cancer 11 | 2,398
active Crohn's disease 10 | 922
adrenocortical carcinoma 10 | 1,428
interstitial cystitis 10 | 2,312
Breast Neoplasms 9 | 445
Cognitive delay 9 | 608
Dull intelligence 9 | 645
Global developmental delay 9 | 608
Low intelligence 9 | 645
Mammary Neoplasms 9 | 425
Mental Retardation 9 | 645
Mental and motor retardation 9 | 608
Mental deficiency 9 | 645
Poor school performance 9 | 645
breast carcinoma 9 | 1,638
Alzheimer's disease 8 | 658
Autosomal recessive predisposition 8 | 1,442
Depressive disorder 7 | 409
Epilepsy 7 | 792
Kidney disease 7 | 430
Prostatic Neoplasms 7 | 495
Stomach Neoplasms 7 | 300
Toxic encephalopathy 7 | 141
active ulcerative colitis 7 | 764
ductal carcinoma in situ 7 | 1,745
juvenile dermatomyositis 7 | 1,187
medulloblastoma 7 | 720
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
pediatric high grade glioma 7 | 1,064
spina bifida 7 | 1,074
Arthritis 6 | 290
Bipolar Disorder 6 | 666
Blastic phase chronic myeloid leukemia 6 | 58
Carcinoma, Hepatocellular 6 | 228
Chronic Myelocytic Leukemia Accelerated Phase 6 | 59
Diffuse large B-cell lymphoma 6 | 39
Hyperalgesia 6 | 83
Liver cancer 6 | 604
Liver carcinoma 6 | 240
Lung Neoplasms 6 | 232
Lymphoma, Large B-Cell, Diffuse 6 | 34
Mental Depression 6 | 333
Muscle hypotonia 6 | 571
Nerve Degeneration 6 | 121
Neurodegenerative disease 6 | 414
Ovarian Neoplasms 6 | 102
Philadelphia chromosome-positive acute lymphoblastic leukemia 6 | 47
Seizures 6 | 596
Splenomegaly 6 | 190
cutaneous lupus erythematosus 6 | 1,057
cystic fibrosis 6 | 1,696
non primary Sjogren syndrome sicca 6 | 891
primary Sjogren syndrome 6 | 735
Asthma 5 | 385
Waldenstrons macroglobulinemia 5 | 765
acute quadriplegic myopathy 5 | 1,158
aldosterone-producing adenoma 5 | 665
esophageal adenocarcinoma 5 | 737
nasopharyngeal carcinoma 5 | 1,058
pituitary cancer 5 | 1,972

Tissue

Endocrine System 81 | 18,159
Blood and immune system 80 | 16,909
Digestive Tract 80 | 17,369
Liver and Pancreas 80 | 16,750
Male tissues 80 | 17,142
Nervous System 80 | 16,725
Skin and soft tissues 80 | 17,230
Urinary Tract 80 | 16,678
Female tissues 79 | 17,400
Respiratory system 79 | 16,393
Cardiovascular System 78 | 15,192

Target Family

Kinase 67 | 634
Enzyme 9 | 4,145
Non-IDG 7 | 12,091
Transcription Factor 1 | 1,400

GO Function

kinase activity 84 | 84
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Putative postmeiotic segregation increased 2-like protein 1 PMS2P1 Tdark Enzyme -2.19299 339.5 0
Ribosomal protein S6 kinase alpha-6 RPS6KA6 Tchem Kinase -1.26563 21.6 158
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase PKMYT1 Tchem Kinase -1.27237 19.2 364
Ribosomal protein S6 kinase alpha-3 RPS6KA3 Tchem Kinase -2.50143 325.4 425
HMG domain-containing protein 3 HMGXB3 Tdark Transcription Factor -0.15127 1.49 73
Serine/threonine-protein kinase D3 PRKD3 Tchem Kinase -1.23218 13.2 295
Serine/threonine-protein kinase Nek1 NEK1 Tchem Kinase -1.62443 47.0 85
Putative postmeiotic segregation increased 2-like protein 11 PMS2P11 Tdark Enzyme -2.19299 339.5 0
Phosphatidylcholine:ceramide cholinephosphotransferase 1 SGMS1 Tchem Enzyme -1.61164 41.6 0
Pyruvate kinase PKLR PKLR Tbio Kinase -2.37549 231.1 391