Development Level

Tbio 7 | 11,445
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal behavior 1 | 298
abnormal embryo size 1 | 220
abnormal lens morphology 1 | 81
cataract 1 | 92
decreased circulating triglyce... 1 | 79
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
hypoactivity 1 | 132

Disease

osteosarcoma 7 | 7,950
ovarian cancer 6 | 8,520
Carcinoma 5 | 11,493
lung cancer 5 | 4,740
medulloblastoma, large-cell 5 | 6,241
atypical teratoid / rhabdoid tumor 4 | 5,112
Autosomal recessive predisposition 3 | 1,442
glioblastoma 3 | 5,792
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
primitive neuroectodermal tumor 3 | 3,035
psoriasis 3 | 6,694
Babinski Reflex 2 | 100
Cerebellar Ataxia 2 | 304
Cognitive delay 2 | 608
Epilepsy 2 | 792
Friedreich ataxia 2 | 24
Global developmental delay 2 | 608
Hyperreflexia 2 | 209
Hypertrophic Cardiomyopathy 2 | 117
Lethargy 2 | 77
Leukodystrophy 2 | 55
Mental and motor retardation 2 | 608
Muscle Weakness 2 | 170
Muscle hypotonia 2 | 571
Nystagmus 2 | 317
Pick disease 2 | 1,894
Seizures 2 | 596
adult high grade glioma 2 | 3,801
astrocytic glioma 2 | 2,597
cystic fibrosis 2 | 1,696
diabetes mellitus 2 | 1,728
group 3 medulloblastoma 2 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
malignant mesothelioma 2 | 3,232
ulcerative colitis 2 | 1,819
Abnormal mitochondria in muscle tissue 1 | 20
Abnormal visual evoked potential 1 | 26
Acquired immunodeficiency syndrome 1 | 197
Acute necrotizing encephalopathy 1 | 14
Ataxia, Appendicular 1 | 25
Blepharoptosis 1 | 231
Brain Edema 1 | 50
Breast Neoplasms 1 | 445
CSF lactate increased 1 | 33
Cardiomegaly 1 | 116
Cardiomyopathies 1 | 110
Cardiomyopathy 1 | 116
Cerebellar Dysmetria 1 | 56
Cerebral Edema 1 | 30
Comatose 1 | 56
Congenital pes cavus 1 | 88
Congestive heart failure 1 | 113
Corneal edema 1 | 14
Death in childhood 1 | 14
Decreased sensory nerve conduction velocities (NCV) 1 | 8
Decreased vibratory sense 1 | 7
Diabetes mellitus type 2 1 | 69
Diphtheria 1 | 40
Disease Models, Animal 1 | 155
Downward slant of palpebral fissure 1 | 158
Dysarthria 1 | 192
Electrocardiogram abnormal 1 | 81
Epilepsy characterized by intractable complex partial seizures 1 | 28
Gait imbalance 1 | 17
Growth delay 1 | 114
Growth failure 1 | 114
Growth retardation 1 | 115
Heart failure 1 | 162
Learning disability 1 | 17
Leigh disease 1 | 100
Liver Failure 1 | 73
Mitochondrial Complex 1 Deficiency 1 | 28
Mitochondrial complex I deficiency 1 | 46
NADH:Q(1) Oxidoreductase deficiency 1 | 24
Neoplasm Metastasis 1 | 168
Neurogenic Muscular Atrophy 1 | 139
Neurogenic muscle atrophy, especially in the lower limbs 1 | 139
Pallor of optic disc 1 | 39
Pertussis 1 | 20
Poor growth 1 | 114
Posterior fossa cyst 1 | 8
Progressive macrocephaly 1 | 18
Respiratory Failure 1 | 104
Retrognathia 1 | 54
Scoliosis 1 | 44
Scrapie 1 | 17
Sensorineural Hearing Loss (disorder) 1 | 284
Sensory neuropathy 1 | 20
Sideroblastic anemia 1 | 20
Skeletal muscle atrophy 1 | 139
Spastic Ataxia 1 | 18
Sphincter disturbances 1 | 16
Succinic semialdehyde dehydrogenase deficiency 1 | 16
Tall stature 1 | 34
Treatment Refractory Type 2 Diabetes Mellitus 1 | 53
Very poor growth 1 | 114
West Syndrome 1 | 28
X-linked dominant 1 | 57
muscle degeneration 1 | 139

Tissue

Blood and immune system 9 | 16,909
Cardiovascular System 9 | 15,192
Digestive Tract 9 | 17,369
Endocrine System 9 | 18,159
Female tissues 9 | 17,400
Liver and Pancreas 9 | 16,750
Male tissues 9 | 17,142
Nervous System 9 | 16,725
Respiratory system 9 | 16,393
Skin and soft tissues 9 | 17,230
Urinary Tract 9 | 16,678

Target Family

Non-IDG 5 | 12,091
Enzyme 3 | 4,145
Epigenetic 1 | 242

GO Function

iron-sulfur cluster binding 9 | 9
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cysteine desulfurase, mitochondrial NFS1 Tbio Enzyme -1.70267 46.3 131
Cytosolic Fe-S cluster assembly factor NUBP1 NUBP1 Tbio Non-IDG -1.31867 20.0 105
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 Tclin Enzyme -1.42734 26.2 214
40S ribosomal protein S3 RPS3 Tbio Non-IDG -2.19489 157.7 218
Frataxin, mitochondrial FXN Tbio Non-IDG -3.02739 1114.8 403
Glutaredoxin-3 GLRX3 Tbio Non-IDG -1.93135 90.3 243
4-aminobutyrate aminotransferase, mitochondrial ABAT Tclin Enzyme -2.02391 104.3 204
Cytosolic Fe-S cluster assembly factor NARFL NARFL Tbio Non-IDG -2.13690 133.3 122
Elongator complex protein 3 ELP3 Tbio Epigenetic -1.75885 53.5 124