Development Level

Tbio 74 | 11,178
Tchem 41 | 1,885
Tclin 13 | 612
Tdark 11 | 6,569

IMPC Phenotype

decreased bone mineral density 5 | 126
preweaning lethality, complete... 5 | 979
decreased total body fat amoun... 4 | 207
decreased vertical activity 4 | 208
preweaning lethality, incomple... 4 | 499
abnormal behavior 3 | 298
abnormal bone structure 3 | 187
cataract 3 | 92
decreased bone mineral content 3 | 151
decreased circulating iron lev... 3 | 32
decreased grip strength 3 | 116
enlarged heart 3 | 210
increased circulating alkaline... 3 | 122
increased circulating choleste... 3 | 66
abnormal femur morphology 2 | 14
abnormal heart morphology 2 | 162
abnormal seminal vesicle morph... 2 | 114
decreased blood urea nitrogen ... 2 | 51
decreased body length 2 | 101
decreased circulating choleste... 2 | 93
decreased circulating phosphat... 2 | 27
decreased heart rate 2 | 18
decreased mean platelet volume 2 | 25
embryonic lethality prior to t... 2 | 278
hyperactivity 2 | 148
hypoactivity 2 | 132
improved glucose tolerance 2 | 79
increased circulating HDL chol... 2 | 80
increased circulating amylase ... 2 | 25
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
polydactyly 2 | 7
prolonged RR interval 2 | 8
small kidney 2 | 16
thin skin 2 | 2
abnormal clavicle morphology 1 | 6
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal forebrain morphology 1 | 10
abnormal hindbrain morphology 1 | 10
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal limb position 1 | 3
abnormal locomotor behavior 1 | 24
abnormal male genitalia morpho... 1 | 3
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal pelvic girdle bone mo... 1 | 12
abnormal pericardium morpholog... 1 | 26
abnormal radius morphology 1 | 8
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal rib morphology 1 | 10
abnormal scapula morphology 1 | 3
abnormal skin condition 1 | 6
abnormal testis morphology 1 | 43
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 18
abnormal vocalization 1 | 21
decreased IgM level 1 | 1
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
decreased threshold for audito... 1 | 26
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged spleen 1 | 41
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
increased anti-nuclear antigen... 1 | 19
increased blood urea nitrogen ... 1 | 48
increased circulating bilirubi... 1 | 16
increased circulating creatini... 1 | 38
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
male infertility 1 | 123
short tibia 1 | 97
small heart 1 | 10
small ovary 1 | 1
small spleen 1 | 19
small superior vagus ganglion 1 | 74
small testis 1 | 58
small uterus 1 | 3
trunk curl 1 | 16
vertebral transformation 1 | 12

Disease

Carcinoma 101 | 11,192
psoriasis 61 | 6,514
ovarian cancer 58 | 8,297
osteosarcoma 49 | 7,766
medulloblastoma, large-cell 46 | 6,086
lung cancer 40 | 4,607
glioblastoma 38 | 5,635
Cancer 36 | 2,388
non-small cell lung cancer 33 | 2,799
atypical teratoid / rhabdoid tumor 31 | 4,971
intraductal papillary-mucinous neoplasm (IPMN) 31 | 3,204
ependymoma 30 | 4,559
group 3 medulloblastoma 30 | 4,002
lung carcinoma 29 | 2,755
pancreatic ductal adenocarcinoma liver metastasis 29 | 1,911
lung adenocarcinoma 28 | 2,627
Autosomal recessive predisposition 26 | 1,407
adult high grade glioma 26 | 3,701
intraductal papillary-mucinous adenoma (IPMA) 26 | 2,872
interstitial cystitis 25 | 2,237
pancreatic cancer 25 | 2,322
Breast cancer 24 | 3,469
intraductal papillary-mucinous carcinoma (IPMC) 23 | 2,902
invasive ductal carcinoma 23 | 2,867
Prostatic Neoplasms 21 | 472
malignant mesothelioma 21 | 3,135
tuberculosis 21 | 1,963
Astrocytoma, Pilocytic 20 | 3,006
diabetes mellitus 20 | 1,683
oligodendroglioma 20 | 2,768
cystic fibrosis 19 | 1,629
pituitary cancer 19 | 1,915
ductal carcinoma in situ 18 | 1,686
Hypertension 17 | 372
ulcerative colitis 17 | 1,765
primitive neuroectodermal tumor 16 | 2,957
subependymal giant cell astrocytoma 16 | 2,230
Kidney cancer 15 | 2,548
Schizophrenia 14 | 1,136
adrenocortical carcinoma 14 | 1,385
astrocytoma 14 | 1,113
breast carcinoma 14 | 1,589
Depressive disorder 13 | 401
astrocytic glioma 13 | 2,530
Atopic dermatitis 11 | 915
Failure to gain weight 11 | 359
Hypertensive disease 11 | 278
Liver disease 11 | 227
Pediatric failure to thrive 11 | 359
Pick disease 11 | 1,856
active Crohn's disease 11 | 882
chronic rhinosinusitis 11 | 505
cutaneous lupus erythematosus 11 | 1,016
primary pancreatic ductal adenocarcinoma 11 | 1,071
Anemia 10 | 353
Breast Neoplasms 10 | 423
Chemical and Drug Induced Liver Injury 10 | 188
Malaria 10 | 155
Osteoporosis 10 | 348
group 4 medulloblastoma 10 | 1,806
mucosa-associated lymphoid tissue lymphoma 10 | 473
Hepatomegaly 9 | 280
Kidney disease 9 | 411
Liver Cirrhosis, Experimental 9 | 733
Mammary Neoplasms 9 | 403
Melanoma 9 | 689
Multiple myeloma 9 | 1,296
Obesity 9 | 655
Thalassemia 9 | 50
Vascular disease 9 | 294
acute quadriplegic myopathy 9 | 1,133
Congenital adrenal hyperplasia 8 | 71
Epilepsy 8 | 775
Intellectual disability 8 | 998
Seizures 8 | 584
colon cancer 8 | 1,428
esophageal adenocarcinoma 8 | 696
pancreatic carcinoma 8 | 555
pediatric high grade glioma 8 | 1,035
Acute kidney injury 7 | 67
Atherosclerosis 7 | 276
Autistic Disorder 7 | 358
Cataract 7 | 290
Cholestasis 7 | 154
Dull intelligence 7 | 634
Endometriosis 7 | 521
Heart disease 7 | 288
Hemolytic anemia 7 | 73
Liver Cirrhosis 7 | 173
Low intelligence 7 | 634
Lung Neoplasms 7 | 217
Mental Retardation 7 | 634
Mental deficiency 7 | 634
Muscle hypotonia 7 | 562
Poor school performance 7 | 634
Psychotic Disorders 7 | 150
Sickle Cell Anemia 7 | 50
Splenomegaly 7 | 186
periodontitis 7 | 280
Rheumatoid arthritis 6 | 1,156

Tissue

Endocrine System 132 | 18,159
Female tissues 126 | 17,400
Skin and soft tissues 124 | 17,230
Digestive Tract 123 | 17,369
Liver and Pancreas 123 | 16,750
Male tissues 121 | 17,142
Blood and immune system 120 | 16,909
Urinary Tract 117 | 16,678
Respiratory system 115 | 16,393
Nervous System 113 | 16,725
Cardiovascular System 90 | 15,192

Target Family

Enzyme 70 | 4,145
Non-IDG 63 | 12,091
Epigenetic 5 | 242
Transporter 1 | 473

GO Function

iron ion binding 139 | 139
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Neutrophil gelatinase-associated lipocalin LCN2 Tbio Enzyme -3.35178 2368.1 847
Arachidonate 12-lipoxygenase, 12S-type ALOX12 Tchem Enzyme -2.35458 223.8 137
Cytochrome P450 2A13 CYP2A13 Tbio Non-IDG -2.14858 139.9 122
Prostacyclin synthase PTGIS Tbio Enzyme -2.55019 341.8 152
Putative inactive cytochrome P450 family member 4Z2 CYP4Z2P Tdark Non-IDG -0.68998 9.87 0
Cytochrome P450 3A4 CYP3A4 Tclin Enzyme -3.65839 4688.0 397
Steroid 21-hydroxylase CYP21A2 Tbio Enzyme 0.00000 214
Cytochrome P450 1B1 CYP1B1 Tchem Non-IDG -2.93702 904.4 260
Vitamin D 25-hydroxylase CYP2R1 Tbio Enzyme -1.96830 95.4 152
Steroid 17-alpha-hydroxylase/17,20 lyase CYP17A1 Tclin Enzyme -3.09734 1226.2 369