Development Level

Tbio 20 | 11,445
Tchem 3 | 1,598
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 5 | 979
decreased total body fat amoun... 3 | 207
abnormal behavior 2 | 298
abnormal bone structure 2 | 187
abnormal embryo size 2 | 220
decreased body weight 2 | 161
decreased circulating HDL chol... 2 | 68
decreased exploration in new e... 2 | 11
impaired glucose tolerance 2 | 75
abnormal craniofacial morpholo... 1 | 33
abnormal eye morphology 1 | 68
abnormal hindbrain morphology 1 | 10
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
decreased bone mineral content 1 | 151
decreased circulating LDL chol... 1 | 38
decreased circulating aspartat... 1 | 34
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased prepulse inhibition 1 | 82
decreased spleen weight 1 | 10
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased body length 1 | 32
increased bone mineral content 1 | 108
increased circulating chloride... 1 | 41
increased circulating sodium l... 1 | 71
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
pale yolk sac 1 | 25
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
tremors 1 | 39

Disease

Carcinoma 19 | 11,493
medulloblastoma, large-cell 15 | 6,241
ependymoma 14 | 4,679
glioblastoma 12 | 5,792
ovarian cancer 12 | 8,520
psoriasis 12 | 6,694
atypical teratoid / rhabdoid tumor 11 | 5,112
lung cancer 11 | 4,740
oligodendroglioma 11 | 2,850
Schizophrenia 10 | 1,160
adult high grade glioma 10 | 3,801
osteosarcoma 10 | 7,950
subependymal giant cell astrocytoma 10 | 2,287
Astrocytoma, Pilocytic 9 | 3,081
astrocytic glioma 9 | 2,597
lung carcinoma 9 | 2,843
Intellectual disability 8 | 1,016
Kidney cancer 8 | 2,613
primitive neuroectodermal tumor 8 | 3,035
Bipolar Disorder 7 | 666
group 3 medulloblastoma 7 | 4,104
Autistic Disorder 6 | 364
Cancer 6 | 2,499
Pick disease 6 | 1,894
lung adenocarcinoma 6 | 2,716
malignant mesothelioma 6 | 3,232
non-small cell lung cancer 6 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
Autism spectrum disorder 5 | 101
group 4 medulloblastoma 5 | 1,855
invasive ductal carcinoma 5 | 2,951
Breast cancer 4 | 3,578
Depressive disorder 4 | 409
Epilepsy 4 | 792
Fragile X syndrome 4 | 34
Major Depressive Disorder 4 | 301
Muscle hypotonia 4 | 571
Parkinson's disease 4 | 392
Unipolar Depression 4 | 250
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
tuberculosis 4 | 2,010
Adenoma 3 | 167
Amyotrophic lateral sclerosis 3 | 451
Anxiety 3 | 136
Anxiety disease 3 | 113
Brain disease 3 | 96
Cerebellar Ataxia 3 | 304
Cognitive delay 3 | 608
Delayed speech and language development 3 | 112
Developmental Disabilities 3 | 23
Dull intelligence 3 | 645
Global developmental delay 3 | 608
Huntington's disease 3 | 76
Hypertension 3 | 396
Hypothyroidism 3 | 122
Language Delay 3 | 112
Liver cancer 3 | 604
Low intelligence 3 | 645
Melanoma 3 | 711
Mental Retardation 3 | 645
Mental and motor retardation 3 | 608
Mental deficiency 3 | 645
Mood Disorders 3 | 184
Multiple myeloma 3 | 1,332
Muscle Spasticity 3 | 195
Myopathy 3 | 185
Neurodegenerative disease 3 | 414
Obesity 3 | 678
Pain 3 | 103
Poor school performance 3 | 645
Respiratory Failure 3 | 104
Seizures 3 | 596
Speech Delay 3 | 112
Speech impairment 3 | 112
Strabismus 3 | 270
acute myeloid leukemia 3 | 783
acute quadriplegic myopathy 3 | 1,158
adrenocortical carcinoma 3 | 1,428
breast carcinoma 3 | 1,638
cystic fibrosis 3 | 1,696
ductal carcinoma in situ 3 | 1,745
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
juvenile dermatomyositis 3 | 1,187
non primary Sjogren syndrome sicca 3 | 891
pancreatic cancer 3 | 2,398
pituitary cancer 3 | 1,972
spina bifida 3 | 1,074
Acromegaly 2 | 51
Adenoid Cystic Carcinoma 2 | 99
Carcinoma, Adenoid Cystic 2 | 99
Decreased tendon reflex 2 | 122
Dementia 2 | 175
Endometrial cancer 2 | 311
Hyperreflexia 2 | 209
Neurodevelopmental Disorders 2 | 70
Pituitary adenoma 2 | 38
Skin cancer 2 | 469
hereditary spastic paraplegia 2 | 318

Tissue

Digestive Tract 23 | 17,369
Endocrine System 23 | 18,159
Nervous System 23 | 16,725
Blood and immune system 22 | 16,909
Female tissues 22 | 17,400
Male tissues 22 | 17,142
Skin and soft tissues 22 | 17,230
Cardiovascular System 21 | 15,192
Liver and Pancreas 21 | 16,750
Respiratory system 21 | 16,393
Urinary Tract 21 | 16,678

Target Family

Non-IDG 18 | 12,091
Enzyme 5 | 4,145
GPCR 1 | 408
Ion Channel 1 | 344

GO Function

ionotropic glutamate receptor ... 25 | 25
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
43 kDa receptor-associated protein of the synapse RAPSN Tbio Non-IDG -2.09902 132.1 134
Neuropilin and tolloid-like protein 2 NETO2 Tbio Non-IDG -1.66114 47.4 144
Vesicle-fusing ATPase NSF Tbio Enzyme -2.93271 688.8 206
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas GNAS Tbio Non-IDG -2.63356 1389.7 509
Flotillin-1 FLOT1 Tbio Non-IDG -2.13455 128.8 277
Neuropilin and tolloid-like protein 1 NETO1 Tbio Non-IDG -1.00021 11.6 74
Oligophrenin-1 OPHN1 Tbio Non-IDG -1.66634 53.6 42
E3 ubiquitin-protein ligase NEDD4 NEDD4 Tchem Enzyme -2.44046 259.8 167
Ras-related protein Rab-4A RAB4A Tbio Enzyme -2.20077 148.7 256
Disks large homolog 2 DLG2 Tbio Non-IDG -1.75838 53.6 227