Development Level

Tbio 78 | 11,445
Tclin 24 | 613
Tchem 15 | 1,598
Tdark 1 | 6,588

Collection

Ion Channel: IDG Consortium (T... 4 | 99

IMPC Phenotype

abnormal behavior 7 | 298
preweaning lethality, complete... 7 | 979
preweaning lethality, incomple... 6 | 499
decreased total body fat amoun... 5 | 207
increased startle reflex 4 | 112
abnormal gait 3 | 69
absent startle reflex 3 | 24
decreased prepulse inhibition 3 | 82
hyperactivity 3 | 148
increased mean corpuscular vol... 3 | 92
abnormal brain morphology 2 | 13
abnormal head morphology 2 | 10
abnormal locomotor behavior 2 | 24
abnormal retina morphology 2 | 71
decreased body weight 2 | 161
decreased circulating total pr... 2 | 49
decreased startle reflex 2 | 75
enlarged heart 2 | 210
hydroencephaly 2 | 14
impaired glucose tolerance 2 | 75
increased bone mineral content 2 | 108
increased mean corpuscular hem... 2 | 96
increased or absent threshold ... 2 | 101
increased prepulse inhibition 2 | 32
thrombocytopenia 2 | 56
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal cecum morphology 1 | 7
abnormal ear morphology 1 | 9
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal heart morphology 1 | 162
abnormal maxilla morphology 1 | 17
abnormal pancreas morphology 1 | 13
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal startle reflex 1 | 15
cardiovascular system phenotyp... 1 | 36
decreased body length 1 | 101
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased vertical activity 1 | 208
edema 1 | 59
embryonic lethality prior to t... 1 | 278
enlarged cecum 1 | 5
enlarged lymph nodes 1 | 37
enlarged uterus 1 | 11
hydrometra 1 | 53
hypoactivity 1 | 132
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral density 1 | 72
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating iron lev... 1 | 30
increased circulating magnesiu... 1 | 10
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
increased vertical activity 1 | 24
mammalian phenotype 1 | 17
prenatal lethality 1 | 28
short tibia 1 | 97
small superior vagus ganglion 1 | 74
tremors 1 | 39

Disease

Carcinoma 81 | 11,493
ovarian cancer 66 | 8,520
medulloblastoma, large-cell 63 | 6,241
glioblastoma 62 | 5,792
psoriasis 60 | 6,694
osteosarcoma 55 | 7,950
ependymoma 52 | 4,679
atypical teratoid / rhabdoid tumor 50 | 5,112
adult high grade glioma 45 | 3,801
lung cancer 44 | 4,740
oligodendroglioma 41 | 2,850
Astrocytoma, Pilocytic 40 | 3,081
Breast cancer 39 | 3,578
primitive neuroectodermal tumor 38 | 3,035
Pick disease 34 | 1,894
group 3 medulloblastoma 34 | 4,104
astrocytic glioma 33 | 2,597
Kidney cancer 31 | 2,613
Cancer 29 | 2,499
lung adenocarcinoma 29 | 2,716
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,291
lung carcinoma 26 | 2,843
malignant mesothelioma 26 | 3,232
colon cancer 25 | 1,478
intraductal papillary-mucinous adenoma (IPMA) 25 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 25 | 2,989
invasive ductal carcinoma 24 | 2,951
subependymal giant cell astrocytoma 24 | 2,287
pancreatic cancer 23 | 2,398
Epilepsy 22 | 792
Heart disease 21 | 306
Schizophrenia 21 | 1,160
cystic fibrosis 21 | 1,696
diabetes mellitus 21 | 1,728
pituitary cancer 21 | 1,972
acute quadriplegic myopathy 19 | 1,158
group 4 medulloblastoma 19 | 1,855
non-small cell lung cancer 19 | 2,890
Alzheimer's disease 17 | 658
breast carcinoma 17 | 1,638
ductal carcinoma in situ 16 | 1,745
juvenile dermatomyositis 16 | 1,187
tuberculosis 16 | 2,010
Seizures 15 | 596
interstitial cystitis 15 | 2,312
ulcerative colitis 15 | 1,819
Liver Cirrhosis, Experimental 14 | 769
dermatomyositis 14 | 966
Brugada syndrome 13 | 29
Long QT syndrome 13 | 39
adrenocortical carcinoma 13 | 1,428
Atrial Fibrillation 11 | 124
Autosomal recessive predisposition 11 | 1,442
Bipolar Disorder 11 | 666
Down syndrome 11 | 499
Duchenne muscular dystrophy 11 | 601
Intellectual disability 11 | 1,016
Liver cancer 11 | 604
Long QT syndrome 1 11 | 20
Multiple myeloma 11 | 1,332
active ulcerative colitis 11 | 764
astrocytoma 11 | 1,146
pediatric high grade glioma 11 | 1,064
primary pancreatic ductal adenocarcinoma 11 | 1,109
progressive supranuclear palsy 11 | 676
Hypertension 10 | 396
Melanoma 10 | 711
Multiple Sclerosis 10 | 540
Amyotrophic lateral sclerosis 9 | 451
Cardiomyopathy 9 | 116
Cerebrovascular disease 9 | 238
Cognitive delay 9 | 608
Global developmental delay 9 | 608
Mental and motor retardation 9 | 608
Skin cancer 9 | 469
Syncope 9 | 22
Toxic encephalopathy 9 | 141
Waldenstrons macroglobulinemia 9 | 765
active Crohn's disease 9 | 922
gastric carcinoma 9 | 807
non primary Sjogren syndrome sicca 9 | 891
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
Atopic dermatitis 8 | 952
Cardiac Arrhythmia 8 | 103
Depressive disorder 8 | 409
Dull intelligence 8 | 645
Endometrial cancer 8 | 311
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Poor school performance 8 | 645
Romano-Ward Syndrome 8 | 12
Ventricular arrhythmia 8 | 27
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 510
fibroadenoma 8 | 559
Crohn's disease 7 | 321
Mental Depression 7 | 333
Rheumatoid arthritis 7 | 1,191
acute myeloid leukemia 7 | 783
aldosterone-producing adenoma 7 | 665

Tissue

Endocrine System 115 | 18,159
Digestive Tract 113 | 17,369
Female tissues 113 | 17,400
Male tissues 112 | 17,142
Nervous System 112 | 16,725
Skin and soft tissues 112 | 17,230
Liver and Pancreas 111 | 16,750
Urinary Tract 110 | 16,678
Respiratory system 108 | 16,393
Blood and immune system 106 | 16,909
Cardiovascular System 100 | 15,192

Target Family

Non-IDG 62 | 12,091
Ion Channel 27 | 344
Enzyme 17 | 4,145
Kinase 6 | 634
Transporter 3 | 473
Epigenetic 1 | 242
GPCR 1 | 408
Transcription Factor 1 | 1,400

GO Function

ion channel binding 118 | 118
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Neuroplastin NPTN Tbio Non-IDG -2.31075 211.6 201
Leucine-rich repeat-containing protein 26 LRRC26 Tbio Ion Channel -1.02699 11.3 81
Huntingtin HTT Tchem Non-IDG -3.36282 2294.8 599
Sodium channel protein type 10 subunit alpha SCN10A Tclin Ion Channel -3.17690 1469.3 126
Pannexin-1 PANX1 Tbio Ion Channel -2.59888 418.5 154
Potassium voltage-gated channel subfamily E member 3 KCNE3 Tbio Ion Channel -1.63683 41.4 75
14-3-3 protein theta YWHAQ Tchem Non-IDG -2.43493 235.4 358
Plakophilin-2 PKP2 Tbio Non-IDG -2.10355 135.3 243
Potassium voltage-gated channel subfamily D member 3 KCND3 Tclin Ion Channel -2.34610 217.9 162
Potassium voltage-gated channel subfamily E member 4 KCNE4 Tbio Ion Channel -1.17671 15.9 99