Development Level

Tclin 3 | 612

IMPC Phenotype

abnormal behavior 1 | 298
abnormal colon morphology 1 | 3
abnormal duodenum morphology 1 | 4
abnormal eye anterior chamber ... 1 | 9
abnormal spleen morphology 1 | 55
abnormal vertebrae morphology 1 | 18
decreased heart weight 1 | 27
enlarged lymph nodes 1 | 37
female infertility 1 | 60
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased heart rate 1 | 23
male infertility 1 | 123

Disease

Acute myeloid leukemia, disease 3 | 30
Cancer 3 | 2,499
Carcinoma 3 | 11,493
Metastatic malignant melanoma 3 | 9
Metastatic renal cell carcinoma 3 | 5
Primary cutaneous T-cell lymphoma 3 | 29
Relapsing remitting multiple sclerosis 3 | 14
Renal transplant rejection 3 | 13
Rheumatoid arthritis 3 | 1,191
interstitial cystitis 3 | 2,312
malignant mesothelioma 3 | 3,232
medulloblastoma, large-cell 3 | 6,241
Alopecia 2 | 115
Angle class 2 malocclusion 2 | 57
Angle class 3 malocclusion 2 | 57
Anti-nuclear factor positive 2 | 18
Apraxias 2 | 27
Arthralgia 2 | 90
Arthritis, Rheumatoid 2 | 174
C-reactive protein increased 2 | 15
Chronic diarrhea 2 | 29
Decreased joint mobility 2 | 53
ESR raised 2 | 20
Elevated C-reactive protein level 2 | 15
Hepatomegaly 2 | 285
Hypersensitivity reaction type II disease 2 | 253
Iridocyclitis 2 | 19
Joint swelling 2 | 26
Juvenile rheumatoid arthritis 2 | 111
Juvenile rheumatoid factor-negative polyarthritis 2 | 9
Liver Cirrhosis, Experimental 2 | 769
Lymphadenopathy 2 | 62
Malocclusion 2 | 57
Multiple Sclerosis 2 | 540
Oligoarticular juvenile arthritis 2 | 9
Pauciarticular juvenile rheumatoid arthritis 2 | 9
Pneumonia 2 | 174
Polyarthritis 2 | 11
Recurrent fungal infections 2 | 13
Schizophrenia 2 | 1,160
Severe combined immunodeficiency 2 | 51
Splenomegaly 2 | 190
Type 1 diabetes mellitus 2 | 109
cutaneous lupus erythematosus 2 | 1,057
glioblastoma 2 | 5,792
lung cancer 2 | 4,740
lung carcinoma 2 | 2,843
psoriasis 2 | 6,694
Absence of eyebrows 1 | 31
Acquired immunodeficiency syndrome 1 | 197
Agammaglobulinemia 1 | 34
Alopecia areata 1 | 41
Aplasia/Hypoplasia of the eyebrow 1 | 31
Autoimmune hemolytic anemia 1 | 31
Berylliosis 1 | 28
Biopsy shows villous atrophy 1 | 16
Chronic schizophrenia 1 | 16
Common variable immunodeficiency 1 | 101
Congenital hypoplasia of thymus 1 | 15
Crohn Disease 1 | 45
Diphtheria 1 | 40
Dry skin 1 | 75
Duodenal villous atrophy 1 | 16
Edema 1 | 81
Eosinophilia 1 | 28
Exanthema 1 | 43
Exfoliative dermatitis 1 | 24
Fever 1 | 138
Glomerulonephritis 1 | 46
Graves' disease 1 | 24
HIV Infections 1 | 102
Hepatosplenomegaly 1 | 22
Human immunodeficiency virus infectious disease 1 | 138
IgG Deficiency 1 | 22
Immunoglobulin A deficiency (disorder) 1 | 19
Immunologic Deficiency Syndromes 1 | 113
Increased susceptibility to bacterial infections 1 | 42
Lymphopenia 1 | 67
Lymphoproliferative syndrome 1 | 58
Otitis Media 1 | 52
Paranasal Sinus Diseases 1 | 34
Prone to bacterial infection 1 | 42
Pruritus 1 | 58
Recurrent bacterial infection 1 | 42
Recurrent bronchitis 1 | 23
Recurrent respiratory infections 1 | 141
Recurrent viral infections 1 | 15
Sezary Syndrome 1 | 27
Sezary's disease 1 | 15
Sinusitis 1 | 65
Small intestine biopsy shows villous atrophy 1 | 16
Sparse or absent eyebrows 1 | 31
Sparse/absent eyebrows 1 | 31
Variable degree of villous atrophy 1 | 16
Villous atrophy 1 | 16
Villous atrophy of intestine 1 | 16
Vitiligo 1 | 73
X- linked recessive 1 | 110
Xerosis 1 | 75
non-small cell lung carcinoma 1 | 317

Tissue

Blood and immune system 3 | 16,909
Cardiovascular System 3 | 15,192
Digestive Tract 3 | 17,369
Endocrine System 3 | 18,159
Female tissues 3 | 17,400
Liver and Pancreas 3 | 16,750
Male tissues 3 | 17,142
Nervous System 3 | 16,725
Respiratory system 3 | 16,393
Skin and soft tissues 3 | 17,230
Urinary Tract 3 | 16,678

Target Family

Non-IDG 3 | 12,091

GO Function

interleukin-2 binding 3 | 3
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interleukin-2 receptor subunit beta IL2RB Tclin Non-IDG -2.17998 125.4 654
Interleukin-2 receptor subunit alpha IL2RA Tclin Non-IDG -3.02107 927.8 1917
Cytokine receptor common subunit gamma IL2RG Tclin Non-IDG -2.81131 605.4 421