Development Level

Tbio 84 | 11,445
Tchem 18 | 1,598
Tclin 8 | 613
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 7 | 979
preweaning lethality, incomple... 7 | 499
enlarged heart 4 | 210
abnormal behavior 3 | 298
abnormal bone structure 3 | 187
abnormal behavioral response t... 2 | 66
abnormal embryo size 2 | 220
abnormal maxilla morphology 2 | 17
abnormal seminal vesicle morph... 2 | 114
abnormal sleep behavior 2 | 70
decreased circulating bilirubi... 2 | 19
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased prepulse inhibition 2 | 82
decreased vertical activity 2 | 208
embryonic lethality prior to o... 2 | 239
hyperactivity 2 | 148
impaired glucose tolerance 2 | 75
increased blood urea nitrogen ... 2 | 48
male infertility 2 | 123
tremors 2 | 39
abnormal bone mineralization 1 | 38
abnormal cranium morphology 1 | 36
abnormal ear morphology 1 | 9
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal liver morphology 1 | 17
abnormal locomotor behavior 1 | 24
abnormal lung morphology 1 | 26
abnormal pancreas morphology 1 | 13
abnormal retinal blood vessel ... 1 | 26
abnormal skin coloration 1 | 25
abnormal tail movements 1 | 12
abnormal tooth morphology 1 | 24
abnormal vibrissa morphology 1 | 25
absent startle reflex 1 | 24
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating amylase ... 1 | 28
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating sodium l... 1 | 22
decreased fasted circulating g... 1 | 65
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased lymphocyte cell numb... 1 | 83
decreased startle reflex 1 | 75
edema 1 | 59
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged kidney 1 | 14
enlarged spleen 1 | 41
enlarged uterus 1 | 11
female infertility 1 | 60
head bobbing 1 | 5
hemorrhage 1 | 23
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased spleen weight 1 | 10
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
kinked tail 1 | 2
limb grasping 1 | 41
mammalian phenotype 1 | 17
polycystic kidney 1 | 15
premature death 1 | 5
prolonged PR interval 1 | 15
prolonged ST segment 1 | 36
small superior vagus ganglion 1 | 74
thrombocytopenia 1 | 56

Disease

Carcinoma 86 | 11,493
ovarian cancer 73 | 8,520
glioblastoma 67 | 5,792
osteosarcoma 65 | 7,950
atypical teratoid / rhabdoid tumor 56 | 5,112
psoriasis 56 | 6,694
ependymoma 55 | 4,679
Cancer 54 | 2,499
Breast cancer 50 | 3,578
lung carcinoma 49 | 2,843
medulloblastoma, large-cell 46 | 6,241
invasive ductal carcinoma 44 | 2,951
lung cancer 43 | 4,740
malignant mesothelioma 43 | 3,232
Astrocytoma, Pilocytic 42 | 3,081
pancreatic cancer 42 | 2,398
non-small cell lung cancer 40 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 39 | 2,955
lung adenocarcinoma 39 | 2,716
adult high grade glioma 38 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 37 | 2,989
interstitial cystitis 35 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 34 | 3,291
pituitary cancer 34 | 1,972
primary pancreatic ductal adenocarcinoma 32 | 1,109
group 3 medulloblastoma 30 | 4,104
Duchenne muscular dystrophy 29 | 601
Kidney cancer 28 | 2,613
primitive neuroectodermal tumor 28 | 3,035
ulcerative colitis 27 | 1,819
cystic fibrosis 26 | 1,696
gastric carcinoma 26 | 807
subependymal giant cell astrocytoma 26 | 2,287
diabetes mellitus 25 | 1,728
ductal carcinoma in situ 25 | 1,745
group 4 medulloblastoma 25 | 1,855
breast carcinoma 24 | 1,638
juvenile dermatomyositis 24 | 1,187
Autosomal recessive predisposition 22 | 1,442
adrenocortical carcinoma 21 | 1,428
oligodendroglioma 21 | 2,850
pediatric high grade glioma 21 | 1,064
Liver Cirrhosis, Experimental 20 | 769
Pick disease 20 | 1,894
astrocytic glioma 19 | 2,597
autosomal dominant Emery-Dreifuss muscular dystrophy 19 | 510
Kidney disease 18 | 430
acute quadriplegic myopathy 18 | 1,158
cutaneous lupus erythematosus 17 | 1,057
Becker muscular dystrophy 16 | 191
limb girdle muscular dystrophy 2A 16 | 213
Atopic dermatitis 15 | 952
Rheumatoid arthritis 15 | 1,191
colon cancer 15 | 1,478
tuberculosis 15 | 2,010
Breast Neoplasms 14 | 445
Mammary Neoplasms 14 | 425
dermatomyositis 14 | 966
esophageal adenocarcinoma 14 | 737
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
Endometriosis 13 | 540
Schizophrenia 13 | 1,160
astrocytoma 13 | 1,146
nasopharyngeal carcinoma 13 | 1,058
Heart disease 12 | 306
urothelial carcinoma 12 | 318
Hypertensive disease 11 | 292
Neoplasm Invasiveness 11 | 161
Prostatic Neoplasms 11 | 495
interstitial lung disease 11 | 298
progressive supranuclear palsy 11 | 676
Atherosclerosis 10 | 291
Bipolar Disorder 10 | 666
Down syndrome 10 | 499
Melanoma 10 | 711
Multiple Sclerosis 10 | 540
Osteoporosis 10 | 363
Short stature 10 | 531
active ulcerative colitis 10 | 764
nephrosclerosis 10 | 333
sonic hedgehog group medulloblastoma 10 | 467
Alzheimer's disease 9 | 658
Arthritis 9 | 290
Cerebrovascular disease 9 | 238
Colorectal Neoplasms 9 | 243
Coronary artery disease 9 | 268
Hypertension 9 | 396
non primary Sjogren syndrome sicca 9 | 891
Abortion, Spontaneous 8 | 109
Glaucoma 8 | 239
Hypersensitivity reaction type II disease 8 | 253
Liver Cirrhosis 8 | 181
Myocardial Ischemia 8 | 169
Polycystic ovary syndrome 8 | 360
Spontaneous abortion 8 | 113
Vascular disease 8 | 319
non-small cell lung carcinoma 8 | 317
periodontitis 8 | 293
Multiple myeloma 7 | 1,332
primary Sjogren syndrome 7 | 735

Tissue

Endocrine System 111 | 18,159
Digestive Tract 110 | 17,369
Female tissues 110 | 17,400
Liver and Pancreas 110 | 16,750
Urinary Tract 110 | 16,678
Blood and immune system 109 | 16,909
Nervous System 109 | 16,725
Respiratory system 109 | 16,393
Skin and soft tissues 109 | 17,230
Male tissues 108 | 17,142
Cardiovascular System 105 | 15,192

Target Family

Non-IDG 85 | 12,091
Enzyme 17 | 4,145
Kinase 6 | 634
GPCR 3 | 408
Transcription Factor 1 | 1,400

GO Function

integrin binding 112 | 112
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transmembrane glycoprotein NMB GPNMB Tbio Non-IDG -2.05817 130.8 293
Disintegrin and metalloproteinase domain-containing protein 15 ADAM15 Tbio Enzyme -1.87408 84.1 301
Intercellular adhesion molecule 4 ICAM4 Tbio Non-IDG -1.43430 28.1 158
Disintegrin and metalloproteinase domain-containing protein 9 ADAM9 Tchem Enzyme -2.08807 122.3 258
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Prolyl endopeptidase FAP FAP Tchem Enzyme -2.37686 226.2 406
A disintegrin and metalloproteinase with thrombospondin motifs 8 ADAMTS8 Tbio Enzyme -1.14483 14.5 153
Fibronectin FN1 Tchem Non-IDG -3.09873 1208.8 1583
Collagen alpha-1(XVI) chain COL16A1 Tbio Non-IDG -0.91124 6.99 35
Cadherin-17 CDH17 Tbio Non-IDG -3.38219 2005.5 312