Development Level

Tchem 6 | 1,598
Tclin 5 | 613

IMPC Phenotype

decreased circulating creatini... 1 | 39
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating iron lev... 1 | 30
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499

Disease

Cancer 10 | 2,499
Carcinoma 10 | 11,493
medulloblastoma, large-cell 10 | 6,241
osteosarcoma 9 | 7,950
ovarian cancer 8 | 8,520
glioblastoma 7 | 5,792
atypical teratoid / rhabdoid tumor 6 | 5,112
ependymoma 6 | 4,679
psoriasis 6 | 6,694
Autosomal recessive predisposition 5 | 1,442
Breast cancer 5 | 3,578
Kidney cancer 5 | 2,613
lung cancer 5 | 4,740
oligodendroglioma 5 | 2,850
Delayed bone age 4 | 136
Fetal Growth Retardation 4 | 189
Infant, Small for Gestational Age 4 | 176
Intrauterine retardation 4 | 176
Leukemia 4 | 104
Schizophrenia 4 | 1,160
adult high grade glioma 4 | 3,801
astrocytic glioma 4 | 2,597
dermatomyositis 4 | 966
invasive ductal carcinoma 4 | 2,951
non-small cell lung cancer 4 | 2,890
primitive neuroectodermal tumor 4 | 3,035
Astrocytoma, Pilocytic 3 | 3,081
Broad flat nasal bridge 3 | 236
Byzanthine arch palate 3 | 194
Congenital clinodactyly 3 | 57
Curvature of digit 3 | 57
Fatigue 3 | 182
Hepatomegaly 3 | 285
Hyperglycemia 3 | 137
Hypoplastic mandible condyle 3 | 275
Mandibular hypoplasia 3 | 275
Micrognathism 3 | 275
Myopia 3 | 176
Nasal bridge wide 3 | 236
Obesity 3 | 678
Orbital separation excessive 3 | 244
Pectus excavatum 3 | 100
Pick disease 3 | 1,894
Prostatic Neoplasms 3 | 495
Radially deviated fingers 3 | 38
Rheumatoid arthritis 3 | 1,191
Short stature 3 | 531
Somatic mutation 3 | 61
Splenomegaly 3 | 190
Weight decreased 3 | 103
acute myeloid leukemia 3 | 783
breast carcinoma 3 | 1,638
diabetes mellitus 3 | 1,728
ductal carcinoma in situ 3 | 1,745
group 3 medulloblastoma 3 | 4,104
group 4 medulloblastoma 3 | 1,855
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
juvenile dermatomyositis 3 | 1,187
lung adenocarcinoma 3 | 2,716
malignant mesothelioma 3 | 3,232
pancreatic cancer 3 | 2,398
pancreatic carcinoma 3 | 562
spina bifida 3 | 1,074
Chronic otitis media 2 | 52
Congenital anomaly of face 2 | 56
DOID:2627 2 | 94
Distortion of face 2 | 46
Dysmorphic facies 2 | 46
Fever 2 | 138
Frontal bossing 2 | 157
Funny looking face 2 | 46
Hernia, Inguinal 2 | 89
High forehead 2 | 102
High, narrow palate 2 | 32
Hyperalgesia 2 | 83
Hypogammaglobulinemia 2 | 35
Isolated cases 2 | 72
Joint hyperflexibility 2 | 78
Large auricle 2 | 87
Large dysplastic ears 2 | 87
Large pinnae 2 | 87
Large prominent ears 2 | 87
Large protruding ears 2 | 87
Large, floppy ears 2 | 87
Low Birth Weights 2 | 69
Macrotia 2 | 87
Mental impairment 2 | 95
Parkinson Disease 2 | 64
Prominent eyes 2 | 96
Prominent globes 2 | 96
Protruding eyes 2 | 96
Recurrent respiratory infections 2 | 141
Respiratory Insufficiency 2 | 132
Sensorineural Hearing Loss (disorder) 2 | 284
Small for gestational age (disorder) 2 | 69
Tall forehead 2 | 102
Triangular face 2 | 58
ear infection chronic 2 | 52
facial deformity 2 | 46

Tissue

Blood and immune system 11 | 16,909
Digestive Tract 11 | 17,369
Endocrine System 11 | 18,159
Female tissues 11 | 17,400
Male tissues 11 | 17,142
Nervous System 11 | 16,725
Skin and soft tissues 11 | 17,230
Urinary Tract 11 | 16,678
Cardiovascular System 10 | 15,192
Liver and Pancreas 10 | 16,750
Respiratory system 10 | 16,393

Target Family

Kinase 9 | 634
Enzyme 1 | 4,145
Non-IDG 1 | 12,091

GO Function

insulin receptor substrate bin... 11 | 11
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Insulin receptor-related protein INSRR Tchem Kinase -2.00991 100.4 287
Insulin-like growth factor 1 receptor IGF1R Tclin Kinase -3.37168 2419.5 1686
Protein kinase C delta type PRKCD Tclin Kinase -2.18452 141.4 804
Insulin receptor INSR Tclin Kinase -2.50045 306.8 1417
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -3.02404 981.4 501
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.51919 316.4 758
Tyrosine-protein phosphatase non-receptor type 11 PTPN11 Tchem Enzyme -3.11032 1400.0 1077
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform PIK3CB Tchem Kinase -2.29043 197.8 384
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform PIK3CA Tclin Kinase -3.04988 1076.8 484