Development Level

Tbio 217 | 10,625
Tchem 66 | 1,890
Tclin 18 | 602
Tdark 10 | 7,003

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 15 | 633
preweaning lethality, incomple... 9 | 260
decreased total body fat amoun... 6 | 186
decreased lean body mass 5 | 195
embryonic lethality prior to t... 5 | 187
increased circulating alkaline... 5 | 119
decreased body length 4 | 108
decreased bone mineral density 4 | 126
decreased circulating glucose ... 4 | 121
increased grip strength 4 | 83
male infertility 4 | 62
abnormal behavior 3 | 226
abnormal embryo size 3 | 112
abnormal tooth morphology 3 | 24
decreased bone mineral content 3 | 157
decreased circulating HDL chol... 3 | 77
decreased circulating insulin ... 3 | 75
decreased circulating triglyce... 3 | 83
decreased rib number 3 | 59
increased leukocyte cell numbe... 3 | 37
increased mean corpuscular vol... 3 | 91
shortened RR interval 3 | 19
abnormal coat/ hair morphology 2 | 18
abnormal femur morphology 2 | 14
abnormal forebrain development 2 | 18
abnormal hindbrain development 2 | 24
abnormal iris morphology 2 | 12
abnormal lung morphology 2 | 15
abnormal midbrain development 2 | 22
abnormal neural tube closure 2 | 37
abnormal retina morphology 2 | 100
abnormal snout morphology 2 | 18
corneal opacity 2 | 25
decreased KLRG1-positive NK ce... 2 | 9
decreased body weight 2 | 174
decreased circulating free fat... 2 | 39
decreased circulating serum al... 2 | 79
decreased circulating sodium l... 2 | 18
decreased eosinophil cell numb... 2 | 41
decreased grip strength 2 | 123
decreased mean corpuscular hem... 2 | 34
decreased mean corpuscular hem... 2 | 19
decreased mean corpuscular vol... 2 | 50
embryonic lethality prior to o... 2 | 148
enlarged heart 2 | 111
female infertility 2 | 34
hydrops fetalis 2 | 22
increased blood urea nitrogen ... 2 | 44
increased body length 2 | 20
increased bone mineral content 2 | 92
increased circulating HDL chol... 2 | 63
increased circulating choleste... 2 | 53
increased circulating free fat... 2 | 17
increased circulating sodium l... 2 | 71
increased fasted circulating g... 2 | 68
increased heart rate 2 | 17
increased hematocrit 2 | 36
increased hemoglobin content 2 | 45
increased lean body mass 2 | 107
increased mean corpuscular hem... 2 | 25
increased or absent threshold ... 2 | 128
increased startle reflex 2 | 38
increased total body fat amoun... 2 | 57
irregularly shaped pupil 2 | 7
narrow eye opening 2 | 15
persistence of hyaloid vascula... 2 | 22
shortened ST segment 2 | 9
small testis 2 | 37
abnormal behavioral response t... 1 | 52
abnormal coping response 1 | 12
abnormal cornea morphology 1 | 24
abnormal gait 1 | 51
abnormal heart left ventricle ... 1 | 20
abnormal heart morphology 1 | 51
abnormal respiratory quotient 1 | 9
abnormal retinal pigmentation 1 | 61
abnormal vocalization 1 | 21
decreased T cell number 1 | 31
decreased caudal vertebrae num... 1 | 49
decreased circulating bilirubi... 1 | 14
decreased circulating potassiu... 1 | 17
decreased effector memory CD8-... 1 | 24
decreased hemoglobin content 1 | 53
decreased lumbar vertebrae num... 1 | 62
dilated heart left ventricle 1 | 10
increased CD4-positive, CD25-p... 1 | 18
increased blood uric acid leve... 1 | 5
increased body weight 1 | 42
increased bone mineral density 1 | 52
increased circulating aspartat... 1 | 17
increased circulating bilirubi... 1 | 16
increased circulating magnesiu... 1 | 10
increased circulating triglyce... 1 | 24
increased mean platelet volume 1 | 19
increased rib number 1 | 41
increased sacral vertebrae num... 1 | 62
premature death 1 | 5
prenatal lethality 1 | 16
short tibia 1 | 82
thrombocytopenia 1 | 46

Disease

ovarian cancer 184 | 8,484
psoriasis 151 | 6,685
osteosarcoma 144 | 7,933
glioblastoma 118 | 5,572
lung cancer 118 | 4,466
medulloblastoma, large-cell 115 | 6,234
Cancer 108 | 2,346
atypical teratoid / rhabdoid tumor 95 | 4,369
Breast cancer 83 | 3,094
invasive ductal carcinoma 80 | 2,950
intraductal papillary-mucinous neoplasm (IPMN) 77 | 3,289
non-small cell lung cancer 74 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 71 | 2,988
lung carcinoma 68 | 2,844
pediatric high grade glioma 68 | 2,712
lung adenocarcinoma 65 | 2,713
pilocytic astrocytoma 65 | 3,086
malignant mesothelioma 64 | 3,162
primitive neuroectodermal tumor 64 | 3,031
pancreatic cancer 62 | 2,300
intraductal papillary-mucinous adenoma (IPMA) 61 | 2,956
oligodendroglioma 56 | 2,849
ductal carcinoma in situ 54 | 1,745
ependymoma 52 | 2,514
interstitial cystitis 52 | 2,299
ulcerative colitis 50 | 2,087
diabetes mellitus 48 | 1,663
subependymal giant cell astrocytoma 48 | 2,287
astrocytoma 43 | 1,493
breast carcinoma 43 | 1,614
tuberculosis 43 | 1,557
Carcinoma 41 | 2,147
colon cancer 41 | 1,475
group 3 medulloblastoma 39 | 2,254
sonic hedgehog group medulloblastoma 38 | 1,482
pancreatic ductal adenocarcinoma liver metastasis 37 | 1,795
pituitary cancer 36 | 1,972
cystic fibrosis 35 | 1,665
group 4 medulloblastoma 35 | 1,875
Multiple myeloma 34 | 1,327
Pick disease 33 | 1,893
juvenile dermatomyositis 33 | 1,189
Alzheimer's disease 32 | 644
adrenocortical carcinoma 32 | 1,427
dermatomyositis 32 | 933
primary pancreatic ductal adenocarcinoma 31 | 1,271
nasopharyngeal carcinoma 30 | 1,056
Neurodegenerative disease 29 | 383
Rheumatoid Arthritis 29 | 1,160
medulloblastoma 29 | 1,524
posterior fossa group A ependymoma 29 | 1,511
acute quadriplegic myopathy 28 | 1,157
adult high grade glioma 28 | 2,148
gastric carcinoma 28 | 832
astrocytic glioma 27 | 2,241
Prostatic Neoplasms 26 | 471
spina bifida 26 | 1,064
Atopic dermatitis 25 | 944
Down syndrome 25 | 548
Mammary Neoplasms 25 | 410
esophageal adenocarcinoma 25 | 737
Lung Neoplasms 24 | 171
Parkinson's disease 24 | 364
atypical teratoid/rhabdoid tumor 24 | 1,095
active Crohn's disease 23 | 918
Kidney disease 22 | 396
Obesity 22 | 616
Stomach Neoplasms 22 | 282
Amyotrophic Lateral Sclerosis 21 | 431
Heart disease 21 | 279
Schizophrenia 21 | 501
Vascular disease 21 | 281
Waldenstrons macroglobulinemia 21 | 765
cutaneous lupus erythematosus 21 | 1,056
non-small cell lung carcinoma 21 | 413
Atherosclerosis 20 | 275
Intellectual disability 20 | 573
acute myeloid leukemia 20 | 780
Liver disease 19 | 219
Neoplasm Metastasis 19 | 138
non primary Sjogren syndrome sicca 19 | 840
Coronary artery disease 18 | 240
Hypertensive disease 18 | 193
Liver carcinoma 18 | 217
Neuropathy 18 | 210
autosomal dominant Emery-Dreifuss muscular dystrophy 18 | 499
posterior fossa group B ependymoma 18 | 1,530
primary Sjogren syndrome 18 | 789
Colonic Neoplasms 17 | 126
Renal Cell Carcinoma 17 | 199
Adenocarcinoma 16 | 115
Adenoma 16 | 165
Cerebrovascular disease 16 | 231
Dementia 16 | 129
Duchenne muscular dystrophy 16 | 602
Endometriosis 16 | 535
Myopathy 16 | 128
sarcoidosis 16 | 358
Arthritis 15 | 248
pancreatic carcinoma 15 | 567

Tissue

Digestive Tract 307 | 18,473
Female tissues 307 | 18,647
Nervous System 307 | 18,561
Endocrine System 305 | 18,512
Liver and Pancreas 305 | 18,136
Male tissues 305 | 17,969
Cardiovascular System 304 | 17,958
Urinary Tract 304 | 18,444
Skin and soft tissues 303 | 18,115
Blood and immune system 302 | 17,995
Respiratory system 296 | 17,484

Target Family

Non-IDG 194 | 11,971
Enzyme 60 | 4,146
Kinase 22 | 634
Transcription Factor 15 | 1,400
Epigenetic 7 | 242
Ion Channel 7 | 341
GPCR 3 | 406
TF/Epigenetic 2 | 38
Nuclear Receptor 1 | 48

GO Function

identical protein binding 311 | 311
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Cardiac phospholamban PLN Tbio Non-IDG -1.89899 84.7 326
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
Microtubule-associated protein RP/EB family member 3 MAPRE3 Tbio Non-IDG -2.14681 132.5 161
TNF receptor-associated factor 2 TRAF2 Tbio Non-IDG -1.85843 68.9 516
Apolipoprotein A-I APOA1 Tchem Non-IDG -3.60439 3516.7 901
Insulin INS Tbio Non-IDG -5.14691 141255.4 1549
Meiosis-specific nuclear structural protein 1 MNS1 Tbio Non-IDG -1.16311 14.2 55
Signal peptide, CUB and EGF-like domain-containing protein 1 SCUBE1 Tbio Non-IDG -1.25952 24.9 65