Development Level

Tbio 790 | 11,651
Tchem 177 | 1,388
Tclin 59 | 612
Tdark 58 | 6,593

Collection

RFA-RM-18-021 7 | 328
Kinase: IDG Consortium (Target... 4 | 125
Ion Channel: IDG Consortium (T... 2 | 99
Kinase: IDG Consortium (Comple... 2 | 37
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 76 | 979
preweaning lethality, incomple... 37 | 499
embryonic lethality prior to t... 28 | 278
abnormal behavior 22 | 298
embryonic lethality prior to o... 21 | 239
decreased total body fat amoun... 18 | 207
decreased bone mineral content 16 | 151
increased circulating alkaline... 16 | 122
abnormal embryo size 15 | 220
abnormal retina morphology 15 | 71
decreased bone mineral density 15 | 126
increased total body fat amoun... 15 | 134
hypoactivity 14 | 132
abnormal bone structure 13 | 187
decreased body weight 13 | 161
enlarged heart 12 | 210
increased lean body mass 12 | 172
abnormal lens morphology 11 | 81
cataract 11 | 92
decreased lean body mass 11 | 135
male infertility 11 | 123
decreased circulating triglyce... 10 | 79
decreased mean corpuscular vol... 10 | 79
increased circulating HDL chol... 10 | 80
increased circulating choleste... 10 | 66
increased fasted circulating g... 10 | 76
abnormal gait 9 | 69
decreased lymphocyte cell numb... 9 | 83
hyperactivity 9 | 148
thrombocytopenia 9 | 56
decreased circulating choleste... 8 | 93
decreased vertical activity 8 | 208
edema 8 | 59
embryonic growth retardation 8 | 106
improved glucose tolerance 8 | 79
increased startle reflex 8 | 112
prenatal lethality prior to he... 8 | 87
abnormal heart morphology 7 | 162
abnormal seminal vesicle morph... 7 | 114
decreased circulating alanine ... 7 | 47
decreased circulating glucose ... 7 | 126
decreased circulating insulin ... 7 | 76
decreased circulating serum al... 7 | 82
decreased neutrophil cell numb... 7 | 42
decreased startle reflex 7 | 75
increased mean platelet volume 7 | 45
increased neutrophil cell numb... 7 | 46
small testis 7 | 58
abnormal cornea morphology 6 | 31
abnormal cranium morphology 6 | 36
abnormal sleep behavior 6 | 70
decreased body length 6 | 101
decreased leukocyte cell numbe... 6 | 73
decreased prepulse inhibition 6 | 82
female infertility 6 | 60
hydrometra 6 | 53
impaired glucose tolerance 6 | 75
increased bone mineral content 6 | 108
increased bone mineral density 6 | 72
increased heart weight 6 | 62
increased leukocyte cell numbe... 6 | 47
increased mean corpuscular vol... 6 | 92
increased red blood cell distr... 6 | 34
short tibia 6 | 97
small superior vagus ganglion 6 | 74
abnormal coat-hair pigmentatio... 5 | 64
decreased circulating HDL chol... 5 | 68
decreased circulating alkaline... 5 | 46
decreased mean corpuscular hem... 5 | 50
decreased red blood cell distr... 5 | 41
enlarged spleen 5 | 41
increased blood urea nitrogen ... 5 | 48
increased circulating serum al... 5 | 22
increased circulating triglyce... 5 | 42
increased grip strength 5 | 41
increased hemoglobin content 5 | 45
increased lymphocyte cell numb... 5 | 32
increased mean corpuscular hem... 5 | 96
increased mean corpuscular hem... 5 | 36
increased monocyte cell number 5 | 63
increased or absent threshold ... 5 | 101
abnormal femur morphology 4 | 14
abnormal lung morphology 4 | 26
abnormal skin morphology 4 | 50
abnormal testis morphology 4 | 43
cardiovascular system phenotyp... 4 | 36
corneal opacity 4 | 32
decreased caudal vertebrae num... 4 | 53
decreased circulating calcium ... 4 | 36
decreased circulating magnesiu... 4 | 13
decreased grip strength 4 | 116
decreased heart weight 4 | 27
decreased mean corpuscular hem... 4 | 31
decreased mean platelet volume 4 | 25
increased circulating LDL chol... 4 | 13
increased circulating creatini... 4 | 38
increased circulating iron lev... 4 | 30
increased circulating total pr... 4 | 28
limb grasping 4 | 41
shortened RR interval 4 | 17

Disease

Carcinoma 709 | 11,493
ovarian cancer 620 | 8,520
osteosarcoma 534 | 7,950
psoriasis 481 | 6,694
medulloblastoma, large-cell 426 | 6,241
glioblastoma 421 | 5,792
lung cancer 400 | 4,740
atypical teratoid / rhabdoid tumor 354 | 5,112
Cancer 344 | 2,499
ependymoma 310 | 4,679
group 3 medulloblastoma 300 | 4,104
Breast cancer 281 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 274 | 3,291
malignant mesothelioma 254 | 3,232
adult high grade glioma 253 | 3,801
non-small cell lung cancer 251 | 2,890
invasive ductal carcinoma 242 | 2,951
lung carcinoma 235 | 2,843
intraductal papillary-mucinous carcinoma (IPMC) 233 | 2,989
Astrocytoma, Pilocytic 226 | 3,081
pancreatic cancer 223 | 2,398
primitive neuroectodermal tumor 219 | 3,035
lung adenocarcinoma 214 | 2,716
oligodendroglioma 213 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 212 | 2,955
Kidney cancer 180 | 2,613
interstitial cystitis 180 | 2,312
subependymal giant cell astrocytoma 175 | 2,287
tuberculosis 167 | 2,010
astrocytic glioma 166 | 2,597
ductal carcinoma in situ 163 | 1,745
ulcerative colitis 159 | 1,819
Autosomal recessive predisposition 157 | 1,442
diabetes mellitus 156 | 1,728
cystic fibrosis 145 | 1,696
breast carcinoma 144 | 1,638
pancreatic ductal adenocarcinoma liver metastasis 142 | 1,962
Multiple myeloma 137 | 1,332
Schizophrenia 130 | 1,160
pituitary cancer 127 | 1,972
colon cancer 125 | 1,478
Pick disease 124 | 1,894
adrenocortical carcinoma 115 | 1,428
group 4 medulloblastoma 114 | 1,855
primary pancreatic ductal adenocarcinoma 111 | 1,109
Intellectual disability 108 | 1,016
astrocytoma 108 | 1,146
juvenile dermatomyositis 104 | 1,187
dermatomyositis 101 | 966
acute quadriplegic myopathy 100 | 1,158
Rheumatoid arthritis 95 | 1,191
cutaneous lupus erythematosus 94 | 1,057
Obesity 91 | 678
Epilepsy 88 | 792
gastric carcinoma 87 | 807
Alzheimer's disease 84 | 658
spina bifida 82 | 1,074
Breast Neoplasms 81 | 445
nasopharyngeal carcinoma 81 | 1,058
Waldenstrons macroglobulinemia 80 | 765
pediatric high grade glioma 80 | 1,064
primary Sjogren syndrome 80 | 735
Mammary Neoplasms 79 | 425
active Crohn's disease 77 | 922
Bipolar Disorder 76 | 666
Liver Cirrhosis, Experimental 75 | 769
Seizures 75 | 596
Short stature 75 | 531
Cognitive delay 74 | 608
Global developmental delay 74 | 608
Mental and motor retardation 74 | 608
Atopic dermatitis 73 | 952
Dull intelligence 73 | 645
Low intelligence 73 | 645
Mental Retardation 73 | 645
Mental deficiency 73 | 645
Poor school performance 73 | 645
Prostatic Neoplasms 72 | 495
Neurodegenerative disease 70 | 414
esophageal adenocarcinoma 69 | 737
acute myeloid leukemia 68 | 783
Depressive disorder 64 | 409
Muscle hypotonia 64 | 571
active ulcerative colitis 64 | 764
Multiple Sclerosis 62 | 540
Vascular disease 60 | 319
Liver carcinoma 59 | 240
Parkinson's disease 59 | 392
Carcinoma, Hepatocellular 58 | 228
Down syndrome 58 | 499
Kidney disease 58 | 430
Lung Neoplasms 58 | 232
Melanoma 58 | 711
pancreatic carcinoma 58 | 562
medulloblastoma 57 | 720
Hypertension 55 | 396
Hypertensive disease 55 | 292
Amyotrophic lateral sclerosis 52 | 451
hepatocellular carcinoma 52 | 547
non primary Sjogren syndrome sicca 52 | 891

Tissue

Endocrine System 1,060 | 18,159
Digestive Tract 1,055 | 17,369
Female tissues 1,052 | 17,400
Skin and soft tissues 1,047 | 17,230
Liver and Pancreas 1,036 | 16,750
Urinary Tract 1,036 | 16,678
Male tissues 1,035 | 17,142
Blood and immune system 1,034 | 16,909
Nervous System 1,033 | 16,725
Respiratory system 1,021 | 16,393
Cardiovascular System 980 | 15,192

Target Family

Non-IDG 630 | 12,091
Enzyme 240 | 4,145
Kinase 87 | 634
Transcription Factor 60 | 1,400
Ion Channel 30 | 344
Epigenetic 15 | 242
GPCR 7 | 408
Transporter 7 | 473
Nuclear Receptor 4 | 48
TF/Epigenetic 3 | 38
oGPCR 1 | 421

GO Function

identical protein binding 1,084 | 1,084
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Amelogenin, X isoform AMELX Tbio Non-IDG -2.84702 695.0 136
Nicotinamide phosphoribosyltransferase NAMPT Tchem Enzyme -2.94790 1054.3 667
Medium-wave-sensitive opsin 1 OPN1MW Tbio GPCR -0.97721 8.41 18
Thrombospondin-1 THBS1 Tbio Non-IDG -3.06622 1281.6 504
T-cell surface glycoprotein CD3 zeta chain CD247 Tbio Non-IDG -2.61157 386.3 882
Endoplasmic reticulum junction formation protein lunapark LNPK Tbio Non-IDG -1.07127 11.1 9
Protein KASH5 CCDC155 Tdark Non-IDG -0.58600 3.79 39
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Chromobox protein homolog 3 CBX3 Tbio Epigenetic -2.00023 90.5 366