Development Level

Tbio 1 | 11,445

IMPC Phenotype

abnormal lens morphology 1 | 81
abnormal vitreous body morphol... 1 | 10
increased startle reflex 1 | 112
preweaning lethality, complete... 1 | 979

Disease

Abdominal Pain 1 | 98
Acute episodes of neuropathic symptoms 1 | 2
Acute intermittent porphyria 1 | 15
Anorexia 1 | 43
Anxiety 1 | 136
Anxiety disease 1 | 113
Cancer 1 | 2,499
Carcinoma 1 | 11,493
Cardiac Arrhythmia 1 | 103
Cardiac conduction abnormalities 1 | 78
Conduction disorder of the heart 1 | 79
Constipation 1 | 181
Depressive disorder 1 | 409
Diarrhea 1 | 253
Dyschezia 1 | 135
Dysuria 1 | 26
EKG abnormalities 1 | 78
Electrocardiogram abnormal 1 | 81
Electrocardiogram change 1 | 78
Elevated heart rate 1 | 25
Elevated urinary delta-aminolevulinic acid 1 | 3
Epilepsy 1 | 792
Erythropoietic protoporphyria 1 | 15
Hereditary coproporphyria 1 | 8
Hyperhidrosis disorder 1 | 81
Hypertensive crisis 1 | 4
Hypertensive disease 1 | 292
Increase in blood pressure 1 | 119
Increased hepatocellular carcinoma risk 1 | 27
Increased incidence of hepatocellular carcinoma 1 | 27
Increased sweating 1 | 81
Inverted follicular keratosis 1 | 3
Liver carcinoma 1 | 240
Muscle Weakness 1 | 170
Myalgia 1 | 54
Nausea 1 | 20
Nausea and vomiting 1 | 97
Paralytic ileus 1 | 5
Paresthesia 1 | 32
Porphyria 1 | 10
Porphyria cutanea tarda 1 | 12
Porphyria, Acute Intermittent 1 | 1
Psychotic episodes 1 | 3
Respiratory Paralysis 1 | 7
Seizures 1 | 596
Sleeplessness 1 | 16
Sweating 1 | 81
Tachycardia 1 | 43
Urinary Incontinence 1 | 50
Urinary Retention 1 | 6
Urine color abnormal 1 | 6
Variegate Porphyria 1 | 10
Vomiting 1 | 116
astrocytic glioma 1 | 2,597
atypical teratoid / rhabdoid tumor 1 | 5,112
ependymoma 1 | 4,679
glioblastoma 1 | 5,792
lung adenocarcinoma 1 | 2,716
lung cancer 1 | 4,740
malignant mesothelioma 1 | 3,232
medulloblastoma, large-cell 1 | 6,241
oligodendroglioma 1 | 2,850
osteosarcoma 1 | 7,950
psoriasis 1 | 6,694

Tissue

Blood and immune system 1 | 16,909
Cardiovascular System 1 | 15,192
Digestive Tract 1 | 17,369
Endocrine System 1 | 18,159
Female tissues 1 | 17,400
Liver and Pancreas 1 | 16,750
Male tissues 1 | 17,142
Nervous System 1 | 16,725
Respiratory system 1 | 16,393
Skin and soft tissues 1 | 17,230
Urinary Tract 1 | 16,678

Target Family

Enzyme 1 | 4,145

GO Function

hydroxymethylbilane synthase a... 1 | 1
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Porphobilinogen deaminase HMBS Tbio Enzyme -2.78202 588.5 255