Development Level

Tbio 6 | 11,651
Tdark 2 | 6,593
Tchem 1 | 1,388

IMPC Phenotype

preweaning lethality, complete... 1 | 979

Disease

Carcinoma 5 | 11,493
osteosarcoma 5 | 7,950
ovarian cancer 5 | 8,520
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
glioblastoma 4 | 5,792
Autosomal recessive predisposition 3 | 1,442
ductal carcinoma in situ 3 | 1,745
group 3 medulloblastoma 3 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
Abnormality of metabolism/homeostasis 2 | 134
Acquired scoliosis 2 | 281
Adult onset 2 | 82
Ascites 2 | 22
Coarse facial features 2 | 108
Curvature of spine 2 | 282
Duchenne muscular dystrophy 2 | 601
Dull intelligence 2 | 645
Gait abnormality 2 | 135
Hepatomegaly 2 | 285
Hernia, Inguinal 2 | 89
Hydrops Fetalis 2 | 21
Intellectual disability 2 | 1,016
Low intelligence 2 | 645
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Multiple myeloma 2 | 1,332
Muscle hypotonia 2 | 571
Myopathy 2 | 185
Neuropathy 2 | 261
Poor school performance 2 | 645
Splenomegaly 2 | 190
Thickened facial skin with coarse facial features 2 | 108
Waldenstrons macroglobulinemia 2 | 765
astrocytoma 2 | 1,146
breast carcinoma 2 | 1,638
fibroadenoma 2 | 559
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
invasive ductal carcinoma 2 | 2,951
lung carcinoma 2 | 2,843
psoriasis 2 | 6,694
subependymal giant cell astrocytoma 2 | 2,287
ulcerative colitis 2 | 1,819
Abnormality of the hip bone 1 | 16
Congenital pectus carinatum 1 | 52
Distal myopathy, Nonaka type 1 | 2
EMG positive sharp waves 1 | 2
EMG: myopathic abnormalities 1 | 22
EMG: myotonic discharges 1 | 2
Edema 1 | 81
Fatty replacement of skeletal muscle 1 | 3
Foot dorsiflexor weakness 1 | 27
Foot-drop 1 | 27
Gait, Drop Foot 1 | 24
Generalized hirsutism 1 | 36
Heart valve disease 1 | 39
Hemiparesis 1 | 34
Hepatitis 1 | 67
Hepatosplenomegaly 1 | 22
Hypertension, Portal 1 | 22
Hypoplasia of nipple 1 | 16
Inclusion body myopathy with Paget disease of bone and frontotemporal dementia 1 | 13
Inclusion body myositis 1 | 13
Irritable bowel syndrome 1 | 60
Joint stiffness 1 | 84
Laryngeal tuberculosis 1 | 3
Limited shoulder movement 1 | 3
Limited wrist extension 1 | 2
Long hallux 1 | 5
Low posterior hairline 1 | 52
Lymphatic obstruction 1 | 21
Metatarsus Varus 1 | 24
Methemoglobinemia 1 | 17
Mildly increased creatine kinase 1 | 20
NONAKA MYOPATHY 1 | 2
Neurogenic bladder 1 | 16
Non-immune hydrops fetalis 1 | 11
ODONTOID HYPOPLASIA 1 | 16
Onset of lymphedema around puberty 1 | 21
Periodontal disease 1 | 40
Periorbital fullness 1 | 9
Pfaundler-Hurler Syndrome 1 | 12
Platyspondyly 1 | 56
Postnatal growth retardation 1 | 57
Pyramidal sign 1 | 29
Quadriparesis 1 | 8
Reflex, Ankle, Absent 1 | 8
Rimmed vacuoles on biopsy 1 | 15
Shoulder girdle weakness 1 | 10
Shoulder weakness 1 | 10
Sialuria 1 | 9
Simple syndactyly of toes, first web space 1 | 23
Skin Ulcer 1 | 48
Sleep Apnea Syndromes 1 | 13
Sly syndrome 1 | 4
Space motion sickness 1 | 3
Synophrys 1 | 40
Tibialis muscle weakness 1 | 2
Toeing-in 1 | 24
Variation in muscle fiber size 1 | 16
Weakness of hip flexors 1 | 2

Tissue

Blood and immune system 7 | 16,909
Cardiovascular System 7 | 15,192
Digestive Tract 7 | 17,369
Endocrine System 7 | 18,159
Female tissues 7 | 17,400
Liver and Pancreas 7 | 16,750
Male tissues 7 | 17,142
Nervous System 7 | 16,725
Respiratory system 7 | 16,393
Skin and soft tissues 7 | 17,230
Urinary Tract 7 | 16,678

Target Family

Enzyme 9 | 4,145

GO Function

hydrolase activity, hydrolyzin... 9 | 9
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myogenesis-regulating glycosidase MYORG Tbio Enzyme 0.04 1.19 28
1,4-alpha-glucan-branching enzyme GBE1 Tbio Enzyme -2.45230 289.3 230
Beta-glucuronidase GUSB Tchem Enzyme -3.12070 1155.3 291
Mycophenolic acid acyl-glucuronide esterase, mitochondrial ABHD10 Tbio Enzyme -0.43556 2.89 33
Beta-klotho KLB Tbio Enzyme -2.02643 82.8 95
Putative inactive beta-glucuronidase protein GUSBP11 GUSBP11 Tdark Enzyme 0.00000 0
Putative inactive beta-glucuronidase-like protein SMA3 GUSBP1 Tdark Enzyme 0.00000 0
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase GNE Tbio Enzyme -2.45989 288.1 185
Chitotriosidase-1 CHIT1 Tbio Enzyme -2.58852 382.5 153